{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:00:52Z","timestamp":1760144452734,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>In newborns, white matter shows a high T2-weighted (T2w) signal in MRI with poor grey\u2013white matter contrast. To increase this contrast, an extremely long echo time (TE) is used in the examination of children. It is not known up to what age this long TE should be used. The purpose of this study was to find up to what age a long TE should be used in infants. In the prospective study, 101 infants (0\u201318 months) underwent cranial MRI at 3 Tesla. T2-weighted Fast Spin Echo sequences with long TE (200 ms) and medium TE (100 ms) were used. The signal intensities of the cortex and white matter were measured and the grey\u2013white matter contrast (MC) was calculated. A cut-off age was determined. The T2w sequences with long TE had a statistically significantly higher MC until the age of six months (medium TE: 0.1 \u00b1 0.05, Long TE: 0.19 \u00b1 0.07; p &lt; 0.001). After the tenth month, the T2w sequence with medium TE provided significantly better MC (Medium TE: 0.1 \u00b1 0.05; long TE: 0.05 \u00b1 0.4; p &lt; 0.001). The use of a long TE is only helpful in the first six months of life. After the tenth month of life, a medium TE should be favored as is used in adult brain MRI.<\/jats:p>","DOI":"10.3390\/children11050511","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:18:36Z","timestamp":1713953916000},"page":"511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Large Numbers for Small Children\u2014Up to What Age Do Infants Benefit from a Longer Echo Time in Cerebral T2 MRI Sequences?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7904-5863","authenticated-orcid":false,"given":"Anne Bettina","family":"Beeskow","sequence":"first","affiliation":[{"name":"Department for Diagnostic and Interventional Radiology, University Hospital Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-3740","authenticated-orcid":false,"given":"Franz Wolfgang","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department for Pediatric Radiology, University Hospital Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timm","family":"Denecke","sequence":"additional","affiliation":[{"name":"Department for Diagnostic and Interventional Radiology, University Hospital Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Sorge","sequence":"additional","affiliation":[{"name":"Department for Pediatric Radiology, University Hospital Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gr\u00e4fe","sequence":"additional","affiliation":[{"name":"Department for Pediatric Radiology, University Hospital Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/adc.48.10.757","article-title":"Quantitative growth and development of human brain","volume":"48","author":"Dobbing","year":"1973","journal-title":"Arch. 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