{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:22:59Z","timestamp":1773328979218,"version":"3.50.1"},"reference-count":98,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: The SARS-CoV-2 pandemic has significantly affected the pediatric population. Long-term sequelae (Long COVID-19) may particularly involve the central nervous system, with possible effects on psychological well-being and quality of life (QoL), aspects that were already influenced by the restrictive measures and general social impact of the pandemic. Methods: We conducted a cross-sectional survey that aims at investigating the neuropsychological effects and the QoL impairment of SARS-CoV-2 on a cohort of children and adolescents in the Abruzzo region (Italy). A questionnaire was submitted to caregivers with the help of the PEDIATOTEM platform. A control group of healthy subjects was also included to distinguish between the effects of infection from the general influence of the pandemic. Results: A total of 569 subjects responded: 396 COVID-19 patients (99 of whom had Long COVID-19) and 111 controls. After the pandemic, when compared with the COVID-19 group, the controls reported significantly increased appetite, sleeping habits, and time spent remotely with friends and a reduction in physical activity and time spent in person with friends. A significant higher rate of controls asked for psychological\/medical support for emotional problems. On the other hand, the Long COVID-19 group showed more fatigue and emotional instability with respect to non-Long-COVID-19 subjects. No differences in QoL results (EuroQOL) were found between the COVID-19 patients and controls, while the Long-COVID-19 subgroup showed significantly higher rates of pain\/discomfort and mood instability, as confirmed by the analysis of variation of responses from the pre-COVID-19 to the post-COVID-19 period. Conclusions: Among COVID-19 patients, neuropsychological and QoL impairment was more evident in the Long COVID-19 subgroup, although emotional and relational issues were also reported by uninfected patients, with a growing request for specialist support as a possible consequence of social restriction.<\/jats:p>","DOI":"10.3390\/children11050532","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T08:59:39Z","timestamp":1714553979000},"page":"532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuropsychological Symptoms and Quality of Life during the COVID-19 Pandemic in Children: A Survey in a Pediatric Population in the Abruzzo Region, Italy"],"prefix":"10.3390","volume":"11","author":[{"given":"Chiara","family":"Marcotullio","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-3160","authenticated-orcid":false,"given":"Marina","family":"Attanasi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Porreca","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics, Department of Medical, Oral and Biotechnological Sciences, \u201cG. d\u2019Annunzio\u201d University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-4292","authenticated-orcid":false,"given":"Paola","family":"Di Filippo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Matricardi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Venanzi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Schiavo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Paone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Science, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Prezioso","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fainardi, V., Meoli, A., Chiopris, G., Motta, M., Skenderaj, K., Grandinetti, R., Bergomi, A., Antodaro, F., Zona, S., and Esposito, S. (2022). Long COVID in Children and Adolescents. Life, 12.","DOI":"10.3390\/life12020285"},{"key":"ref_2","unstructured":"(2024, April 05). AAP Children and COVID-19: State-Level Data Report. Available online: https:\/\/www.aap.org\/en\/pages\/2019-novel-coronavirus-covid-19-infections\/children-and-covid-19-state-level-data-report\/."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"591132","DOI":"10.3389\/fped.2020.591132","article-title":"Epidemiological and Clinical Characteristics of COVID-19 in Children: A Systematic Review and Meta-Analysis","volume":"8","author":"Li","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40124-021-00257-6","article-title":"Current Insights Into the Pathophysiology of Multisystem Inflammatory Syndrome in Children","volume":"9","author":"Vella","year":"2021","journal-title":"Curr. Pediatr. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1038\/s41598-022-13495-5","article-title":"Long-COVID in Children and Adolescents: A Systematic Review and Meta-Analyses","volume":"12","author":"Perelman","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/14737175.2023.2239500","article-title":"Long-Term Central Nervous System (CNS) Consequences of COVID-19 in Children","volume":"23","author":"Parlatini","year":"2023","journal-title":"Expert Rev. Neurother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S1473-3099(21)00703-9","article-title":"A Clinical Case Definition of Post-COVID-19 Condition by a Delphi Consensus","volume":"22","author":"Soriano","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jiph.2023.03.005","article-title":"Prevalence and Risk Factor for Long COVID in Children and Adolescents: A Meta-Analysis and Systematic Review","volume":"16","author":"Zheng","year":"2023","journal-title":"J. Infect. Public Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"40720","DOI":"10.4088\/PCC.21r03218","article-title":"Long COVID in Children and Adolescents","volume":"24","author":"Gupta","year":"2022","journal-title":"Prim. Care Companion CNS Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/dmcn.15185","article-title":"Neurological Effects of COVID-19 in Infants and Children","volume":"64","author":"Stafstrom","year":"2022","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1111\/apa.15870","article-title":"Preliminary Evidence on Long COVID in Children","volume":"110","author":"Buonsenso","year":"2021","journal-title":"Acta Paediatr. Int. J. Paediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/apa.15673","article-title":"Case Report and Systematic Review Suggest That Children May Experience Similar Long-Term Effects to Adults after Clinical COVID-19","volume":"110","author":"Ludvigsson","year":"2021","journal-title":"Acta Paediatr. Int. J. Paediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00127-023-02517-w","article-title":"Emotional and Behavioral Outcomes among Youths with Mental Disorders during the First Covid Lockdown and School Closures in England: A Large Clinical Population Study Using Health Care Record Integrated Surveys","volume":"59","author":"Parlatini","year":"2023","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1001\/jamapediatrics.2021.5840","article-title":"School Closures during Social Lockdown and Mental Health, Health Behaviors, and Well-Being among Children and Adolescents during the First COVID-19 Wave: A Systematic Review","volume":"176","author":"Viner","year":"2022","journal-title":"JAMA Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20503121221086712","DOI":"10.1177\/20503121221086712","article-title":"Effects of COVID-19 Pandemic on Mental Health of Children and Adolescents: A Systematic Review of Survey Studies","volume":"10","author":"Theberath","year":"2022","journal-title":"SAGE Open Med."},{"key":"ref_16","unstructured":"Sigfrid, L., Buonsenso, D., Galvin, A., and Al, E. (2024, April 05). ISARIC Global COVID-19 Paediatric Follow-Up. Available online: https:\/\/isaric.org\/research\/covid-19-clinical-research-resources\/paediatric-follow-up\/."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2217\/fmb-2021-0285","article-title":"Clinical Characteristics, Activity Levels and Mental Health Problems in Children with Long Coronavirus Disease: A Survey of 510 Children","volume":"17","author":"Buonsenso","year":"2022","journal-title":"Future Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s11136-010-9648-y","article-title":"Development of the EQ-5D-Y: A Child-Friendly Version of the EQ-5D","volume":"19","author":"Wille","year":"2010","journal-title":"Qual. Life Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1136\/archdischild-2021-323624","article-title":"Long COVID (Post-COVID-19 Condition) in Children: A Modified Delphi Process","volume":"107","author":"Stephenson","year":"2022","journal-title":"Arch. Dis. Child."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Schiavo, M., Di Filippo, P., Porreca, A., Prezioso, G., Orlandi, G., Rossi, N., Chiarelli, F., and Attanasi, M. (2024). Potential Predictors of Long COVID in Italian Children: A Cross-Sectional Survey. Children, 11.","DOI":"10.3390\/children11020221"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.immuni.2018.12.018","article-title":"The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages","volume":"50","author":"Schulthess","year":"2019","journal-title":"Immunity"},{"key":"ref_22","unstructured":"Core R Team (2019). A Language and Environment for Statistical Computing. R Found. Stat. Comput., 2, Available online: https:\/\/www.R-project.org."},{"key":"ref_23","unstructured":"Istituto Superiore di Sanit\u00e0 (ISS) (2024, April 05). Interim Guidance on Long-COVID Management Principles. Available online: https:\/\/www.iss.it\/documents\/20126\/0\/Rapporto+ISS+COVID-19+n.15_2021_EN.pdf\/dd962ad9-fa53-73dd-7759-55cb5c167675?t=1627575304593."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.23736\/S0026-4946.20.05887-9","article-title":"Impact of COVID-19 on Children: Special Focus on the Psychosocial Aspect","volume":"72","author":"Ghosh","year":"2020","journal-title":"Minerva Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"113429","DOI":"10.1016\/j.psychres.2020.113429","article-title":"Impact of COVID-19 and Lockdown on Mental Health of Children and Adolescents: A Narrative Review with Recommendations","volume":"293","author":"Singh","year":"2020","journal-title":"Psychiatry Res."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Jones, E.A.K., Mitra, A.K., and Bhuiyan, A.R. (2021). Impact of COVID-19 on Mental Health in Adolescents: A Systematic Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052470"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00787-021-01758-x","article-title":"The Impact of School Closure and Social Isolation on Children in Vulnerable Families during COVID-19: A Focus on Children\u2019s Reactions","volume":"31","author":"Larsen","year":"2022","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2022060553","DOI":"10.1542\/peds.2022-060553","article-title":"Pediatric Mental Health Emergencies During 5 COVID-19 Waves in New York City","volume":"152","author":"Levine","year":"2023","journal-title":"Pediatrics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e12150","DOI":"10.1002\/jcv2.12150","article-title":"The Effects of COVID-19 on Child Mental Health: Biannual Assessments up to April 2022 in a Clinical and Two General Population Samples","volume":"3","author":"Zijlmans","year":"2023","journal-title":"JCPP Adv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100288","DOI":"10.1016\/j.xcrm.2021.100288","article-title":"Divergent and Self-Reactive Immune Responses in the CNS of COVID-19 Patients with Neurological Symptoms","volume":"2","author":"Song","year":"2021","journal-title":"Cell Rep. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Stafstrom, C.E., and Jantzie, L.L. (2020). COVID-19: Neurological Considerations in Neonates and Children. Children, 7.","DOI":"10.3390\/children7090133"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jamaneurol.2020.2687","article-title":"Neurologic and Radiographic Findings Associated with COVID-19 Infection in Children","volume":"77","author":"Hacohen","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/09297049.2020.1763938","article-title":"Neurotropic Mechanisms in COVID-19 and Their Potential Influence on Neuropsychological Outcomes in Children","volume":"26","author":"Condie","year":"2020","journal-title":"Child Neuropsychol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/jamaneurol.2021.0504","article-title":"Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome","volume":"78","author":"Larovere","year":"2021","journal-title":"JAMA Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1093\/brain\/awac332","article-title":"Neurological Manifestations of COVID-19 in Adults and Children","volume":"146","author":"Cho","year":"2023","journal-title":"Brain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S2352-4642(22)00004-9","article-title":"Long COVID Symptoms in SARS-CoV-2-Positive Adolescents and Matched Controls (LongCOVIDKidsDK): A National, Cross-Sectional Study","volume":"6","author":"Nygaard","year":"2022","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/head.14319","article-title":"Headache Associated with COVID-19: Epidemiology, Characteristics, Pathophysiology, and Management","volume":"62","year":"2022","journal-title":"Headache"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jpsychires.2022.10.045","article-title":"Psychiatric and Neurological Complications of Long COVID","volume":"156","author":"Zawilska","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3345\/cep.2023.00472","article-title":"Long COVID in Children and Adolescents: Prevalence, Clinical Manifestations, and Management Strategies","volume":"66","author":"Ha","year":"2023","journal-title":"Clin. Exp. Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: Major Findings, Mechanisms and Recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1017\/neu.2022.13","article-title":"Neuropsychiatric Symptoms in Post COVID-19 Long Haulers","volume":"34","author":"Alghamdi","year":"2022","journal-title":"Acta Neuropsychiatr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/wvn.12566","article-title":"Mental Health Effects Prevalence in Children and Adolescents during the COVID-19 Pandemic: A Systematic Review","volume":"19","author":"Butini","year":"2022","journal-title":"Worldviews Evid.-Based Nurs."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12967-020-02399-5","article-title":"Eating Habits and Lifestyle Changes during COVID-19 Lockdown: An Italian Survey","volume":"18","author":"Gualtieri","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Farello, G., D\u2019andrea, M., Quarta, A., Grossi, A., Pompili, D., Altobelli, E., Stagi, S., and Balsano, C. (2022). Children and Adolescents Dietary Habits and Lifestyle Changes during COVID-19 Lockdown in Italy. Nutrients, 14.","DOI":"10.3390\/nu14102135"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Krupa-Kotara, K., Wojtas, G., Grajek, M., Grot, M., Rozmiarek, M., Wypych-\u015alusarska, A., Oleksiuk, K., G\u0142ogowska-Ligus, J., and S\u0142owi\u0144ski, J. (2023). Impact of the COVID-19 Pandemic on Nutrition, Sleep, Physical Activity, and Mood Disorders of Polish Children. Nutrients, 15.","DOI":"10.3390\/nu15081928"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Struckmeyer, N., Biester, T., Kordonouri, O., Weiner, C., Sadeghian, E., Guntermann, C., Kapitzke, K., Weiskorn, J., Galuschka, L., and von Stuelpnagel, K. (2023). Alterations in Dietary Behavior, Appetite Regulation, and Health-Related Quality of Life in Youth with Obesity in Germany during the COVID-19 Pandemic. Nutrients, 15.","DOI":"10.3390\/nu15132936"},{"key":"ref_47","first-page":"295","article-title":"Impact of the COVID-19 Pandemic on the Changes in Dietary Habits, Lifestyle and Physical Activity in the Slovak Population","volume":"74","year":"2023","journal-title":"Rocz. Panstw. Zakl. Hig.\/Ann. Natl. Inst. Hyg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"537","DOI":"10.5005\/jp-journals-10071-24504","article-title":"Assessment of Family Satisfaction of Remote Communication for Critically Ill COVID-19 Patients: An Observational Cohort Study","volume":"27","author":"Varghese","year":"2023","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"106331","DOI":"10.1016\/j.appet.2022.106331","article-title":"A Longitudinal Study on Changes in Food Parenting Practices during COVID-19 and the Role of Parental Well-Being","volume":"180","author":"Larsen","year":"2023","journal-title":"Appetite"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Ferrulli, A., Senesi, P., Terruzzi, I., and Luzi, L. (2022). Eating Habits and Body Weight Changes Induced by Variation in Smell and Taste in Patients with Previous SARS-CoV-2 Infection. Nutrients, 14.","DOI":"10.3390\/nu14235068"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1022669","DOI":"10.3389\/fped.2022.1022669","article-title":"Development of Restrictive Eating Disorders in Children and Adolescents with Long-COVID-Associated Smell and Taste Dysfunction","volume":"10","author":"Brasseler","year":"2022","journal-title":"Front. Pediatr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1177\/01945998221097656","article-title":"Decreasing Incidence of Chemosensory Changes by COVID-19 Variant","volume":"168","author":"Coelho","year":"2023","journal-title":"Otolaryngol.\u2014Head Neck Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101596","DOI":"10.1016\/j.smrv.2022.101596","article-title":"Effects of COVID-19 Home Confinement on Sleep in Children: A Systematic Review","volume":"62","author":"Iranzo","year":"2022","journal-title":"Sleep Med. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jsmc.2023.01.004","article-title":"Sleep During the Pandemic","volume":"18","author":"Catarozoli","year":"2023","journal-title":"Sleep Med. Clin."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Okely, A.D., Kariippanon, K.E., Guan, H., Taylor, E.K., Suesse, T., Cross, P.L., Chong, K.H., Suherman, A., Turab, A., and Staiano, A.E. (2021). Global Effect of COVID-19 Pandemic on Physical Activity, Sedentary Behaviour and Sleep among 3- to 5-Year-Old Children: A Longitudinal Study of 14 Countries. BMC Public Health, 21.","DOI":"10.1186\/s12889-021-10852-3"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jshs.2020.06.005","article-title":"Canadian Children\u2019s and Youth\u2019s Adherence to the 24-h Movement Guidelines during the COVID-19 Pandemic: A Decision Tree Analysis","volume":"9","author":"Guerrero","year":"2020","journal-title":"J. Sport Health Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1139\/apnm-2021-0354","article-title":"Few Canadian Children and Youth Were Meeting the 24-Hour Movement Behaviour Guidelines 6-Months into the COVID-19 Pandemic: Follow-up from a National Study","volume":"46","author":"Moore","year":"2021","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41390-022-02309-z","article-title":"Impact of the COVID-19 Pandemic on Children\u2019s Sleep Habits: An ECHO Study","volume":"93","author":"Lucchini","year":"2023","journal-title":"Pediatr. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5664\/jcsm.9518","article-title":"Impact of COVID-19 Lockdown on Sleep in Children with Autism Spectrum Disorders","volume":"18","author":"Bruni","year":"2022","journal-title":"J. Clin. Sleep Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Wunsch, K., Kienberger, K., and Niessner, C. (2022). Changes in Physical Activity Patterns Due to the COVID-19 Pandemic: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19042250"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rossi, L., Behme, N., and Breuer, C. (2021). Physical Activity of Children and Adolescents during the COVID-19 Pandemic\u2014A Scoping Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182111440"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1123\/jpah.2022-0350","article-title":"The Impacts of COVID-19 Restrictions on Physical Activity in Children and Youth: A Systematic Review of Qualitative Evidence","volume":"20","author":"Eaton","year":"2023","journal-title":"J. Phys. Act. Health"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmi.2022.01.014","article-title":"Prevalence of Post-Acute COVID-19 Syndrome Symptoms at Different Follow-up Periods: A Systematic Review and Meta-Analysis","volume":"28","author":"Alkodaymi","year":"2022","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbi.2021.12.020","article-title":"Fatigue and Cognitive Impairment in Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis","volume":"101","author":"Ceban","year":"2022","journal-title":"Brain. Behav. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1007\/s00431-021-04345-z","article-title":"Long COVID Symptoms and Duration in SARS-CoV-2 Positive Children\u2014A Nationwide Cohort Study","volume":"181","author":"Borch","year":"2022","journal-title":"Eur. J. Pediatr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"ofab440","DOI":"10.1093\/ofid\/ofab440","article-title":"Long COVID and Post-Infective Fatigue Syndrome: A Review","volume":"8","author":"Sandler","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1007\/s00259-021-05294-3","article-title":"Long COVID Hallmarks on [18F]FDG-PET\/CT: A Case-Control Study","volume":"48","author":"Sollini","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1295032","DOI":"10.3389\/fpsyt.2023.1295032","article-title":"A Dual-Factor Model Perspective on Depressed Inpatients: Examining the Dynamics of Mental Health and Therapy Outcomes","volume":"14","author":"Brailovskaia","year":"2023","journal-title":"Front. Psychiatry"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Tk\u00e1\u010dov\u00e1, H., Pavl\u00edkov\u00e1, M., Jenisov\u00e1, Z., Maturkani\u010d, P., and Kr\u00e1lik, R. (2021). Social Media and Students\u2019 Wellbeing: An Empirical Analysis during the COVID-19 Pandemic. Sustainability, 13.","DOI":"10.3390\/su131810442"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S2352-4642(22)00022-0","article-title":"Physical and Mental Health 3 Months after SARS-CoV-2 Infection (Long COVID) among Adolescents in England (CLoCk): A National Matched Cohort Study","volume":"6","author":"Stephenson","year":"2022","journal-title":"Lancet. Child Adolesc. Health"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Conti, E., Sgandurra, G., De Nicola, G., Biagioni, T., Boldrini, S., Bonaventura, E., Buchignani, B., Vecchia, S.D., Falcone, F., and Fedi, C. (2020). Behavioural and Emotional Changes during COVID-19 Lockdown in an Italian Paediatric Population with Neurologic and Psychiatric Disorders. Brain Sci., 10.","DOI":"10.3390\/brainsci10120918"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1017\/S0033291720005358","article-title":"Increases in Depression and Anxiety Symptoms in Adolescents and Young Adults during the COVID-19 Pandemic","volume":"52","author":"Hawes","year":"2022","journal-title":"Psychol. Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Meherali, S., Punjani, N., Louie-Poon, S., Rahim, K.A., Das, J.K., Salam, R.A., and Lassi, Z.S. (2021). Mental Health of Children and Adolescents amidst COVID-19 and Past Pandemics: A Rapid Systematic Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.20944\/preprints202103.0149.v1"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"768036","DOI":"10.3389\/fpubh.2022.768036","article-title":"Psychological Impact of the Very Early Beginning of the COVID-19 Outbreak in Healthcare Workers: A Bayesian Study on the Italian and Swiss Perspectives","volume":"10","author":"Uccella","year":"2022","journal-title":"Front. Public Health"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s00431-023-04854-z","article-title":"Mental Health among Children with Long COVID during the COVID-19 Pandemic","volume":"182","author":"Shorer","year":"2023","journal-title":"Eur. J. Pediatr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"106","DOI":"10.15503\/jecs2023.1.106.123","article-title":"Social Interventions in the Family in the Post-COVID Pandemic Period","volume":"14","author":"Akimjak","year":"2023","journal-title":"J. Educ. Cult. Soc."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.dsx.2020.12.025","article-title":"Long COVID-19: Challenges in the Diagnosis and Proposed Diagnostic Criteria","volume":"15","author":"Raveendran","year":"2021","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/cid\/ciab991","article-title":"Acute and Persistent Symptoms in Children with PCR-Confirmed SARS-CoV-2 Infection Compared to Test-Negative Children in England: Active, Prospective, National Surveillance","volume":"75","author":"Zavala","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1111\/apa.15999","article-title":"Persistent Symptoms in Swedish Children after Hospitalisation Due to COVID-19","volume":"110","author":"Sterky","year":"2021","journal-title":"Acta Paediatr. Int. J. Paediatr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jadohealth.2021.07.027","article-title":"Chronic Pain in Schoolchildren and Its Association With Psychological Wellbeing Before and During the COVID-19 Pandemic","volume":"69","author":"Rau","year":"2021","journal-title":"J. Adolesc. Health"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S2352-4642(21)00198-X","article-title":"Illness Duration and Symptom Profile in Symptomatic UK School-Aged Children Tested for SARS-CoV-2","volume":"5","author":"Molteni","year":"2021","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s10072-020-04575-3","article-title":"Neuroinvasion, Neurotropic, and Neuroinflammatory Events of SARS-CoV-2: Understanding the Neurological Manifestations in COVID-19 Patients","volume":"41","author":"Yachou","year":"2020","journal-title":"Neurol. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/cen3.12676","article-title":"Neuro-COVID-19","volume":"13","author":"Shimohata","year":"2022","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/ana.26041","article-title":"Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019","volume":"89","author":"Gomes","year":"2021","journal-title":"Ann. Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00787-021-01856-w","article-title":"The Impact of COVID-19 Lockdown on Child and Adolescent Mental Health: Systematic Review","volume":"32","author":"Panchal","year":"2023","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jad.2020.06.029","article-title":"An Investigation of Mental Health Status of Children and Adolescents in China during the Outbreak of COVID-19","volume":"275","author":"Duan","year":"2020","journal-title":"J. Affect. Disord."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"566212","DOI":"10.3389\/fpsyg.2020.566212","article-title":"Emotional, Behavioral, and Psychological Impact of the COVID-19 Pandemic","volume":"11","author":"Pedrosa","year":"2020","journal-title":"Front. Psychol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1099\/jmm.0.001231","article-title":"Epidemiological and Clinical Characteristics of Coronavirus Disease (COVID-19) Cases at a Screening Clinic during the Early Outbreak Period: A Single-Centre Study","volume":"69","author":"Khan","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Schneider, E., Hopf, D., Eckstein, M., Scheele, D., Aguilar-Raab, C., Herpertz, S.C., Grinevich, V., and Ditzen, B. (2023). Stress during the COVID-19 Pandemic Moderates Pain Perception and Momentary Oxytocin Levels. J. Clin. Med., 12.","DOI":"10.3390\/jcm12062333"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e12412","DOI":"10.1111\/cob.12412","article-title":"COVID-19 Related Anxiety in Children and Adolescents with Severe Obesity: A Mixed-Methods Study","volume":"10","author":"Abawi","year":"2020","journal-title":"Clin. Obes."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1038\/s41598-021-81720-8","article-title":"Perceived Stress as Mediator for Longitudinal Effects of the COVID-19 Lockdown on Wellbeing of Parents and Children","volume":"11","author":"Achterberg","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"103840","DOI":"10.1016\/j.ridd.2020.103840","article-title":"Psychological Impact of COVID-19 Pandemic in Italian Families of Children with Neurodevelopmental Disorders","volume":"109","author":"Bentenuto","year":"2021","journal-title":"Res. Dev. Disabil."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"106219","DOI":"10.1016\/j.cct.2020.106219","article-title":"Using Digital Technologies in Clinical Trials: Current and Future Applications","volume":"100","author":"Rosa","year":"2021","journal-title":"Contemp. Clin. Trials"},{"key":"#cr-split#-ref_94.1","doi-asserted-by":"crossref","unstructured":"\u0406\u0440\u0438\u043d\u0430 \u0414\u043c\u0438\u0442\u0440\u0456\u0432\u043d\u0430, \u0421. (2024, April 05). Clinical Management of Patients with COVID-19. \"Live\" Clinical Instruction (2021)","DOI":"10.31612\/covid"},{"key":"#cr-split#-ref_94.2","unstructured":"Clinical and Preventive Medicine 2021. Available online: https:\/\/cp-medical.com\/index.php\/journal\/covid-19-live-clinical-instruction."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"E13","DOI":"10.2196\/jmir.4.2.e13","article-title":"Using the Internet for Surveys and Health Research","volume":"4","author":"Eysenbach","year":"2002","journal-title":"J. Med. Internet Res."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Haddad, C., Sacre, H., Zeenny, R.M., Hajj, A., Akel, M., Iskandar, K., and Salameh, P. (2022). Should Samples Be Weighted to Decrease Selection Bias in Online Surveys during the COVID-19 Pandemic? Data from Seven Datasets. BMC Med. Res. Methodol., 22.","DOI":"10.1186\/s12874-022-01547-3"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e14947","DOI":"10.2196\/14947","article-title":"Measurement Properties of the Online EuroQol-5D-Youth Instrument in Children and Adolescents with Type 1 Diabetes Mellitus: Questionnaire Study","volume":"21","author":"Mayoral","year":"2019","journal-title":"J. Med. 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