{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T21:25:37Z","timestamp":1771536337241,"version":"3.50.1"},"reference-count":78,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The main subject of the current review is a specific subtype of headache, which is related to shunt over-drainage and slit ventricle syndrome, in pediatric patients harboring an implanted shunt device for the management of hydrocephalus. This clinical entity, along with its impairment regarding the quality of life of the affected individuals, is generally underestimated. This is partly due to the absence of universally agreed-upon diagnostic criteria, as well as due to a misunderstanding of the interactions among the implicated pathophysiological mechanisms. A lot of attempts have been performed to propose an integrative model, aiming at the determination of all the offending mechanisms of the shunt over-drainage syndrome, as well as the determination of all the clinical characteristics and related symptomatology that accompany these secondary headaches. This subcategory of headache, named postural dependent headache, can be associated with nausea, vomiting, and\/or radiological signs of slim ventricles and\/or subdural collections. The ultimate goal of our review is to draw clinicians\u2019 attention, especially that of those that are managing pediatric patients with permanent, long-standing, ventriculoperitoneal, or, less commonly, ventriculoatrial shunts. We attempted to elucidate all clinical and neurological characteristics that are inherently related to this type of headache, as well as to highlight the current management options. This specific subgroup of patients may eventually suffer from severe, intractable headaches, which may negatively impair their quality of daily living. In the absence of any other clinical condition that could be incriminated as the cause of the headache, shunt over-drainage should not be overlooked. On the contrary, it should be seriously taken into consideration, and its management should be added to the therapeutic armamentarium of such cases, which are difficult to be handled.<\/jats:p>","DOI":"10.3390\/children11050596","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T06:14:42Z","timestamp":1715753682000},"page":"596","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Pediatric Headache as a Manifestation of Shunt Over-Drainage and Slit Ventricle Syndrome in Patients Harboring a Cerebrospinal Fluid Diversion System: A Narrative Literature Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7918-5065","authenticated-orcid":false,"given":"Dimitrios","family":"Panagopoulos","sequence":"first","affiliation":[{"name":"Neurosurgical Department, Pediatric Hospital of Athens, 45701 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maro","family":"Gavra","sequence":"additional","affiliation":[{"name":"Neuro-Radiology Department, Pediatric Hospital of Athens, 45701 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-9739","authenticated-orcid":false,"given":"Efstathios","family":"Boviatsis","sequence":"additional","affiliation":[{"name":"2nd University Neurosurgical Department, Medical School, General Hospital of Athens \u2018Attikon\u2019, University of Athens, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanos","family":"Korfias","sequence":"additional","affiliation":[{"name":"1st University Neurosurgical Department, Medical School, General Hospital of Athens \u2018Evangelismos\u2019, University of Athens, 10676 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios","family":"Themistocleous","sequence":"additional","affiliation":[{"name":"Neurosurgical Department, Pediatric Hospital of Athens, 45701 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s10194-023-01541-0","article-title":"Primary headache epidemiology in children and adolescents: A systematic review and meta-analysis","volume":"24","author":"Onofri","year":"2023","journal-title":"J. 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