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Technology","award":["ZSBK0070"],"award-info":[{"award-number":["ZSBK0070"]}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["2022YFC2705003"],"award-info":[{"award-number":["2022YFC2705003"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["2023YFC2706301"],"award-info":[{"award-number":["2023YFC2706301"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["82141125"],"award-info":[{"award-number":["82141125"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development 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Foundation","award":["82141125"],"award-info":[{"award-number":["82141125"]}]},{"name":"Cyrus Tang Foundation","award":["21Y31900302"],"award-info":[{"award-number":["21Y31900302"]}]},{"name":"Cyrus Tang Foundation","award":["SHDC12019121"],"award-info":[{"award-number":["SHDC12019121"]}]},{"name":"Cyrus Tang Foundation","award":["ZSBK0070"],"award-info":[{"award-number":["ZSBK0070"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>This retrospective study aimed to analyze the treatment effect and prognostic factors of pediatric acute myeloid leukemia (AML) patients with t(8;21). A total of 268 newly diagnosed pediatric AML (pAML) enrolled from 1 January 2005 to 31 December 2022 were retrospectively reviewed, and 50 (18.7%) patients harbored t(8;21) translocation. CR rate, OS, EFS, and RFS were assessed by multivariate Logistic and Cox regression models in these patients. Of the 50 patients, 2 patients abandoned treatment during the first induction course. Of the remaining 48 patients who received double-induction therapy and were included in the final analyses, CR1 and CR2 were 75.0% (36\/48) and 95.8% (46\/48), respectively. The overall three-year OS, EFS, and RFS were 68.4% (95% CI, 55.0\u201385.1), 64.2% (95% CI, 50.7\u201381.4), and 65.5% (95% CI, 51.9\u201382.8), respectively. The presence of loss of sex chromosome (LOS) at diagnosis (n = 21) was associated with a better 3-year OS [87.5% (95% CI, 72.7\u2013100) vs. 52.7% (95% CI, 35.1\u201379.3), p = 0.0089], 3-year EFS [81.6% (95% CI, 64.7\u2013100) vs. 49.7% (95% CI, 32.4\u201376.4), p = 0.023], and 3-year RFS [81.6% (95% CI, 64.7\u2013100) vs. 51.7% (95% CI, 33.9\u201378.9), p = 0.036] than those without LOS (n = 27), and it was also an independent good prognostic factor of OS (HR, 0.08 [95% CI, 0.01\u20130.48], p = 0.005), EFS (HR, 0.22 [95% CI, 0.05\u20130.85], p = 0.029), and RFS (HR, 0.21 [95% CI, 0.05\u20130.90], p = 0.035). However, extramedullary leukemia (EML) featured the independent risk factors of inferior OS (HR, 10.99 [95% CI, 2.08\u201358.12], p = 0.005), EFS (HR, 4.75 [95% CI, 1.10\u201320.61], p = 0.037), and RFS (HR, 6.55 [95% CI, 1.40\u201330.63], p = 0.017) in pediatric individuals with t(8;21) AML. Further analysis of combining LOS with EML indicated that the EML+LOS\u2212 subgroup had significantly inferior OS (92.9%, [95% CI, 80.3\u2013100]), EFS (86.2%, [95% CI, 70.0\u2013100]), and RFS (86.2%, [95% CI, 80.3\u2013100]) compared to the other three subgroups (all p &lt; 0.001). LOS and EML are independent prognostic factors of OS, EFS, and RFS with t(8;21) pAML patients. LOS combined with EML may help improve risk stratification.<\/jats:p>","DOI":"10.3390\/children11050605","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:02:23Z","timestamp":1715947343000},"page":"605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic Factors of Pediatric Acute Myeloid Leukemia Patients with t(8;21) (q22;q22): A Single-Center Retrospective Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Jiapeng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5268-7711","authenticated-orcid":false,"given":"Ziping","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junye","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, National Children\u2019s Medical Center, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0140-6736(18)31041-9","article-title":"Acute myeloid leukaemia","volume":"392","author":"Short","year":"2018","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/jcm4010127","article-title":"Pediatric AML: From Biology to Clinical Management","volume":"4","author":"Zwaan","year":"2015","journal-title":"J. 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