{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:16:42Z","timestamp":1791346602793,"version":"4.3.1"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Canadian Institutes of Health Research","award":["CTP87518"],"award-info":[{"award-number":["CTP87518"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The objective of this study was to assess the relationship of ACS with neonatal outcomes among very preterm infants born to mothers with clinical chorioamnionitis in China. This was a multicenter retrospective cohort study. Study participants included infants born at &lt;32 weeks\u2019 gestation with clinical chorioamnionitis and registered in the Chinese Neonatal Network from 1 January 2019 to 31 December 2020. Infants were divided into two groups: any amount of ACS or no administration of ACS. Multivariable generalized linear models using generalized estimating equations were used to assess the association between ACS and neonatal outcomes among the study population. We identified 2193 infants eligible for this study; 1966 (89.6%) infants had received ACS therapy, and 227 (10.4%) had not received any ACS therapy. Among very preterm infants born to mothers with clinical chorioamnionitis, any ACS usage was significantly associated with decreased risks of early death (aRR 0.56, 95% CI 0.32, 0.99) and severe ROP (aRR 0.51, 95% CI 0.28, 0.93) after adjustment for maternal hypertension, gestational age at birth, Caesarean section, being inborn, and administration of systemic antibiotics to the mother within 24 h before birth. In addition, out of the 2193 infants, the placentas of 1931 infants underwent pathological examination with recorded results. Subsequently, 1490 of these cases (77.2%) were diagnosed with histological chorioamnionitis. In 1490 cases of histologic chorioamnionitis, any ACS usage was significantly related to decreased risks of overall mortality (aRR 0.52, 95% CI 0.31, 0.87), severe ROP (aRR 0.47, 95% CI 0.25, 0.97), and respiratory distress syndrome (aRR 0.52, 95% CI 0.31, 0.87). We concluded that any ACS was associated with reduced risks for neonatal early death and severe ROP among very preterm infants born to mothers with clinical chorioamnionitis.<\/jats:p>","DOI":"10.3390\/children11060680","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T10:06:01Z","timestamp":1717409161000},"page":"680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of Antenatal Corticosteroids with Neonatal Outcomes among Very Preterm Infants Born to Mothers with Clinical Chorioamnionitis: A Multicenter Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Qingqing","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Neonatology, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchen","family":"Wang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Neonatal Diseases, Fudan University, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"},{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Neonatal Diseases, Fudan University, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"},{"name":"Division of Neonatology, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Gu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Neonatal Diseases, Fudan University, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-3301","authenticated-orcid":false,"given":"Shoo K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Maternal-Infants Care Research Centre, and Department of Pediatrics, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada"},{"name":"Department of Pediatrics, The University of Toronto, Toronto, ON M5T 3M7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyi","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Fujian Key Laboratory of Neonatal Diseases, Xiamen Key Laboratory of Neonatal Diseases, Xiamen Children\u2019s Hospital (Children\u2019s Hospital of Fudan University at Xiamen), Xiamen 361006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Cao","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Neonatal Diseases, Fudan University, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"},{"name":"Division of Neonatology, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of Chinese Neonatal Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/apa.15715","article-title":"Chorioamnionitis and neurodevelopmental outcome in very preterm infants from 2007 to 2017-a population-based study","volume":"110","author":"Konzett","year":"2021","journal-title":"Acta Paediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.ajog.2020.09.044","article-title":"Management of clinical chorioamnionitis: An evidence-based approach","volume":"223","author":"Romero","year":"2020","journal-title":"Am. 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