{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:15:25Z","timestamp":1792167325117,"version":"4.4.0"},"reference-count":108,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Longitudinal bone growth is mediated through several mechanisms including macro- and micronutrients, and endocrine and paracrine hormones. These mechanisms can be affected by childhood obesity as excess adiposity may affect signaling pathways, place undue stress on the body, and affect normal physiology. This review describes the physiology of the epiphyseal growth plate, its regulation under healthy weight and obesity parameters, and bone pathology following obesity. A literature review was performed utilizing PubMed, PMC, NIH, and the Cochrane Database of Systematic Reviews pertinent to hormonal and nutritional effects on bone development, child obesity, and pathologic bone development related to weight. The review indicates a complex network of nutrients, hormones, and multi-system interactions mediates long bone growth. As growth of long bones occurs during childhood and the pubertal growth spurt, pediatric bones require adequate levels of minerals, vitamins, amino acids, and a base caloric supply for energy. Recommendations should focus on a nutrient-dense dietary approach rather than restrictive caloric diets to maintain optimal health. In conclusion, childhood obesity has profound multifaceted effects on the developing musculoskeletal system, ultimately causing poor nutritional status during development. Weight loss, under medical supervision, with proper nutritional guidelines, can help counteract the ill effects of childhood obesity.<\/jats:p>","DOI":"10.3390\/children11070817","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T06:04:18Z","timestamp":1719986658000},"page":"817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nutrient and Hormonal Effects on Long Bone Growth in Healthy and Obese Children: A Literature Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Sazid","family":"Hasan","sequence":"first","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrukh","family":"Naseer","sequence":"additional","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen","family":"Zamzam","sequence":"additional","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashem","family":"Mohilldean","sequence":"additional","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Van Wagoner","sequence":"additional","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-3059","authenticated-orcid":false,"given":"Ahmad","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Detroit Medical Center, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehab S.","family":"Saleh","sequence":"additional","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"},{"name":"Department of Orthopedic Surgery, Beaumont Hospital, Royal Oak, MI 48073, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-6775","authenticated-orcid":false,"given":"Virginia","family":"Uhley","sequence":"additional","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Kamel-ElSayed","sequence":"additional","affiliation":[{"name":"School of Medicine, Oakland University William Beaumont, Rochester, MI 48309, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1874325001206010143","article-title":"Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet","volume":"6","author":"Price","year":"2012","journal-title":"Open Orthop. 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