{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:12:11Z","timestamp":1791529931689,"version":"4.3.4"},"reference-count":33,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation","award":["#2020\/07072-0"],"award-info":[{"award-number":["#2020\/07072-0"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["#2020\/16690-0"],"award-info":[{"award-number":["#2020\/16690-0"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["#2021\/12424-6"],"award-info":[{"award-number":["#2021\/12424-6"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["#310895\/2020-0"],"award-info":[{"award-number":["#310895\/2020-0"]}]},{"name":"National Council for Scientific and Technological Development","award":["#2020\/07072-0"],"award-info":[{"award-number":["#2020\/07072-0"]}]},{"name":"National Council for Scientific and Technological Development","award":["#2020\/16690-0"],"award-info":[{"award-number":["#2020\/16690-0"]}]},{"name":"National Council for Scientific and Technological Development","award":["#2021\/12424-6"],"award-info":[{"award-number":["#2021\/12424-6"]}]},{"name":"National Council for Scientific and Technological Development","award":["#310895\/2020-0"],"award-info":[{"award-number":["#310895\/2020-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objectives: This investigation aimed to assess the optimal timing for lip repair in children with cleft lip and palate via 3D anthropometric analysis to evaluate their maxillofacial structures. Methods: The sample comprised 252 digitized dental models, divided into groups according to the following timing of lip repair: G1 (n = 50): 3 months; G2 (n = 50): 5 and 6 months; G3 (n = 26): 8 and 10 months. Models were evaluated at two-time points: T1: before lip repair; T2: at 5 years of age. Linear measurements, area, and Atack index were analyzed. Results: At T1, the intergroup analysis revealed that G1 had statistically significant lower means of I-C\u2032, I-C, C-C\u2032, and the sum of the segment areas compared to G2 (p = 0.0140, p = 0.0082, p = 0.0004, p &lt; 0.0001, respectively). In addition, there was a statistically significant difference when comparing the cleft area between G2 and G3 (p = 0.0346). At T2, the intergroup analysis revealed that G1 presented a statistically significant mean I-C\u2032 compared to G3 (p = 0.0461). In the I-CC\u2019 length analysis, G1 and G3 showed higher means when compared to G2 (p = 0.0039). The I-T\u2032 measurement was statistically higher in G1 than in G2 (p = 0.0251). In the intergroup growth rate analysis, G1 and G2 showed statistically significant differences in the I-C\u2032 measurement compared to G3 (p = 0.0003). In the analysis of the Atack index, there was a statistically significant difference between G1 and the other sample sets (p &lt; 0.0001). Conclusion: Children who underwent surgery later showed better results in terms of the growth and development of the dental arches.<\/jats:p>","DOI":"10.3390\/children11070824","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T14:40:50Z","timestamp":1720449650000},"page":"824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Three-Dimensional Anthropometric Analysis of the Effect of Lip Reconstructive Surgery on Children with Cleft Lip and Palate at Three Different Times"],"prefix":"10.3390","volume":"11","author":[{"given":"Gabriela Mendon\u00e7a","family":"Rando","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-3832","authenticated-orcid":false,"given":"Elo\u00e1 Cristina Passucci","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9221-8052","authenticated-orcid":false,"given":"Paula Karine","family":"Jorge","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-6464","authenticated-orcid":false,"given":"Chiarella","family":"Sforza","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Functional Anatomy Research Center, Faculty of Medicine and Surgery, University of Milan, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio","family":"Menezes","sequence":"additional","affiliation":[{"name":"School of Health Science, State University of Amazonas, Manaus 69065-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2288-9624","authenticated-orcid":false,"given":"Ana L\u00facia Pompeia Fraga","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"},{"name":"Department of Prosthodontics and Periodontology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0811-7302","authenticated-orcid":false,"given":"Simone","family":"Soares","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"},{"name":"Department of Prosthodontics and Periodontology, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5203-796X","authenticated-orcid":false,"given":"Gisele Silva","family":"Dalben","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Tonello","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"},{"name":"Bauru School of Medicine, University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleide Fel\u00edcio Carvalho","family":"Carrara","sequence":"additional","affiliation":[{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-7444","authenticated-orcid":false,"given":"Maria Aparecida Andrade Moreira","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru 17012-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Marchini","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of S\u00e3o Paulo, Bauru 17012-901, Brazil"},{"name":"Hospital for Rehabilitation of Craniofacial Anomalies, University of S\u00e3o Paulo, Bauru 17012-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/S1678-77572012000100003","article-title":"Rehabilitative treatment of cleft lip and palate: Experience of the Hospital for Rehabilitation of Craniofacial Anomalies\/USP (HRAC\/USP)\u2014Part 1: Overall aspects","volume":"20","author":"Freitas","year":"2012","journal-title":"J. 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