{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:15:51Z","timestamp":1760145351783,"version":"build-2065373602"},"reference-count":66,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Van Wyk\u2013Grumbach syndrome (VWGS) refers to the development of peripheral precocious puberty, long-standing hypothyroidism, and gonadal masses; when not diagnosed, an unnecessary gonadectomy may be performed. Herein, we present a case of a 10-year-old girl with Down\u2019s syndrome, short stature, and vitiligo who presented to our hospital with vaginal bleeding and a palpable pelvic mass. Upon ultrasound and topographical examination, bilateral ovarian masses with negative tumor markers were detected. After bilateral gonadectomy, endocrine studies revealed profound hypothyroidism and peripheral puberty that led to the VWGS syndrome diagnosis (TSH 367.3 mUI\/mL, isolated menstruation, indetectable LH, and elevated estradiol). Levothyroxine treatment improved obesity and short stature, and sexual hormone replacement began at 13 years of age. The literature on Van Wyk\u2013Grumbach syndrome shows that it presents most often in women, and classic hypothyroidism symptoms always precede the diagnosis. Approximately 11% of patients have Down\u2019s syndrome, sometimes tumor markers are elevated, and some develop severe symptoms (myopathy, short stature, mental delay, ascites, pericardial effusion, Cullen\u2019s sign, pituitary hyperplasia, and severe anemia) that respond to levothyroxine treatment. Conclusions: Children with peripheral precocious puberty and gonadal masses must be studied for hypothyroidism before any radical decision is made.<\/jats:p>","DOI":"10.3390\/children11070831","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T14:40:50Z","timestamp":1720449650000},"page":"831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Van Wyk\u2013Grumbach Syndrome and Gonadectomy"],"prefix":"10.3390","volume":"11","author":[{"given":"Abril Adriana","family":"Arellano-Llamas","sequence":"first","affiliation":[{"name":"Instituto Mexicano del Seguro Social, UMAE Hospital de Gineco Obstetricia No. 3 La Raza, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Hernandez-Caballero","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, Divisi\u00f3n de Evaluaci\u00f3n de Tecnolog\u00edas en Salud, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efren","family":"Delgado-Mendoza","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, UMAE Hospital General La Raza, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel Alejandro","family":"Catalan-Ruiz","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, UMAE Hospital General La Raza, Mexico City 02990, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jpedsurg.2017.03.014","article-title":"Variability in Surgical Management of Benign Ovarian Neoplasms in Children","volume":"52","author":"Gonzalez","year":"2017","journal-title":"J. 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