{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:21:57Z","timestamp":1772853717316,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>We investigated depression and anxiety levels and related psychological disorders in adolescents with transfusion-dependent thalassemia (TDT) in this study. The study was conducted in two pediatric hematology outpatient clinics and included adolescents with TDT (14.8 \u00b1 2.4 years, n = 40) in the study and compared them with the healthy age-matched control group (14.3 \u00b1 2.3 years, n = 62). The Turkish version of the Revised Child Anxiety and Depression Scale (RCADS) was used to determine depression, anxiety, and related psychologic disorders (obsession, panic disorder, social phobia). Depression, anxiety, obsession, panic disorder, and social phobia scores were significantly higher in the patient group compared with the control (all p &lt; 0.05). Ferritin levels were positively correlated with total depression, general anxiety, separation anxiety, and social phobia scores, but transfusion frequency and young age were the confounding factors. Patients in early adolescence and those who require more frequent blood transfusions are at higher risk of developing psychological disorders; routine screening for mood disorders should be warranted. Serum ferritin level may be a good warning indicator for early recognition of psychologic disorders in TDT patients.<\/jats:p>","DOI":"10.3390\/children11070837","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T09:23:08Z","timestamp":1720603388000},"page":"837","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing Psychological Disorders in Turkish Adolescents with Transfusion-Dependent Thalassemia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-1760","authenticated-orcid":false,"given":"Aylin","family":"Yetim \u015eahin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent Medicine, Faculty of Medicine, Istanbul University, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Biruni University, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Da\u011f","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Istanbul Prof. Dr. Cemil Tascioglu City Hospital, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"T\u00fcrkkan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, University of Health Sciences, Istanbul Prof. Dr. Cemil Tascioglu City Hospital, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melike","family":"Tu\u011frul Aksakal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent Medicine, Faculty of Medicine, Istanbul University, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Memduh","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences, Istanbul Basaksehir Cam and Sakura Hospital, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firdevs","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Adolescent Medicine, Faculty of Medicine, Istanbul University, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-3235","authenticated-orcid":false,"given":"Zeynep","family":"Karaka\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Faculty of Medicine, Istanbul University, 34452 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/gim.2016.173","article-title":"\u03b2-Thalassemia","volume":"19","author":"Origa","year":"2017","journal-title":"Genet. 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