{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:29:56Z","timestamp":1791304196786,"version":"4.3.1"},"reference-count":81,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2019-1.3.1-KK-2019-00007","award":["2019-1.3.1-KK"],"award-info":[{"award-number":["2019-1.3.1-KK"]}]},{"name":"2019-1.3.1-KK-2019-00007","award":["TKP2021-NKTA-36"],"award-info":[{"award-number":["TKP2021-NKTA-36"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Interstitial lung disease (ILD) comprises a group of respiratory diseases affecting the interstitium of the lungs, which occur when a lung injury triggers an abnormal healing response, and an inflammatory process leads to altered diffusion and restrictive respiratory dysfunction. The term \u201cinterstitial\u201d may be misleading, as other components of the lungs are usually also involved (epithelium, airways, endothelium, and so on). Pediatric conditions (childhood interstitial lung disease, chILD) are different from adult forms, as growing and developing lungs are affected and more diverse and less prevalent diseases are seen in childhood. Diffuse parenchymal lung disease (DPLD) and diffuse lung disease (DLD) can be used interchangeably with ILD. Known etiologies of chILD include chronic infections, bronchopulmonary dysplasia, aspiration, genetic mutations leading to surfactant dysfunction, and hypersensitivity pneumonitis due to drugs or environmental exposures. Many forms are seen in disorders with pulmonary involvement (connective tissue disorders, storage diseases, malignancies, and so on), but several conditions have unknown origins (desquamative pneumonitis, pulmonary interstitial glycogenosis, neuroendocrine cell hyperplasia in infancy, and so on). Currently, there is no consensus on pediatric classification; however, age grouping is proposed as some specific forms are more prevalent in infancy (developmental and growth abnormalities, surfactant dysfunction mutations, etc.) and others are usually seen in older cohorts (disorders in normal or immunocompromised hosts, systemic diseases, etc.). Clinical manifestations vary from mild nonspecific symptoms (recurrent respiratory infections, exercise intolerance, failure to thrive, dry cough, etc.) to a severe clinical picture (respiratory distress) and presentation related to the child\u2019s age. The diagnostic approach relies on imaging techniques (CT), but further investigations including genetic tests, BAL, and lung biopsy (VATS) are needed in uncertain cases. Pharmacological treatment is mostly empiric and based on anti-inflammatory and immunomodulatory drugs. Lung transplantation for selected cases in a pediatric transplantation center could be an option; however, limited data and evidence are available regarding long-term survival. International collaboration is warranted to understand chILD entities better and improve the outcomes of these patients.<\/jats:p>","DOI":"10.3390\/children11080904","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T10:34:43Z","timestamp":1722422083000},"page":"904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Clinical Approach to Interstitial Lung Disease in Childhood: A Narrative Review Article"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3234-0432","authenticated-orcid":false,"given":"Simona","family":"Drob\u0148akov\u00e1","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University, 040 01 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Vargov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University, 040 01 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Barkai","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, Pavol Jozef \u0160af\u00e1rik University, 040 01 Kosice, Slovakia"},{"name":"Physiological Controls Research Center, University Research and Innovation Center, \u00d3buda University, 1034 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1002\/ppul.24809","article-title":"Childhood rare lung disease in the 21st century: \u201c-omics\u201d technology advances accelerating discovery","volume":"55","author":"Vece","year":"2020","journal-title":"Pediatr. 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