{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:19:07Z","timestamp":1760145547789,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Society of Genetic Counselors Pediatric and Clinical SIG Research Grant Award"},{"name":"Department of Medical Genetics, Genetic Counselling Training Program"},{"name":"Large Scale Applied Research Project (LSARP) Genome Canada competition"},{"name":"Canadian Institutes of Health Research (CIHR), Genome BC, Genome Quebec"},{"name":"Provincial Health Services Authority"},{"name":"BC Children\u2019s Hospital Foundation"},{"name":"BC Women\u2019s Hospital Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Rapid genome-wide sequencing (rGWS) continues to transform the care provided to infants with genetic conditions in neonatal intensive care units (NICUs). Previous research has demonstrated that rGWS has immense benefits on patient care; however, little is known about non-genetic healthcare providers\u2019 (HCPs) experiences and perspectives of working with rGWS and supporting families through the rGWS testing process in Canadian NICU facilities. To address this gap, we surveyed and conducted semi-structured interviews with non-genetic HCPs of diverse professions from NICUs in British Columbia. Methods: An interpretive description approach was used to analyze interview transcripts to identify patterns and variations in non-genetic HCPs\u2019 experiences and perceptions with rGWS. Results: Participants had varying degrees of exposure to rGWS and levels of comfort with the testing process. Numerous barriers affecting the implementation of rGWS were identified, including low levels of comprehension of rGWS, longer turn-around times than expected, and having to apply for provincial government approval to access testing. Participants desired more education on rGWS, clear guidelines on the use of rGWS in NICUs, and resources for non-genetic HCPs and parents to support implementation. Conclusions: The results from this study can inform the development of workflows and educational resources on the use of rGWS in NICUs, helping to ensure that the NICU team is supported to optimize rGWS implementation.<\/jats:p>","DOI":"10.3390\/children11080910","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T10:34:43Z","timestamp":1722422083000},"page":"910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non-Genetic Healthcare Providers\u2019 Experiences and Perspectives with Rapid Genome-Wide Sequencing in Canadian Neonatal Intensive Care Units"],"prefix":"10.3390","volume":"11","author":[{"given":"Lauren","family":"Piers","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6H 3N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4890-9657","authenticated-orcid":false,"given":"Tasha","family":"Wainstein","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6H 3N1, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7720-4692","authenticated-orcid":false,"given":"Gustavo","family":"Pelligra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Victoria General Hospital, Island Health Authority, Victoria, BC V8Z 6R5, Canada"},{"name":"Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6H 0B3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horacio","family":"Osiovich","sequence":"additional","affiliation":[{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada"},{"name":"Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6H 0B3, Canada"},{"name":"Women\u2019s Health Research Institute, Vancouver, BC V6H 3N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GenCOUNSEL Study","family":"GenCOUNSEL Study","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6H 3N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9896-1314","authenticated-orcid":false,"given":"Alison M.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6H 3N1, Canada"},{"name":"BC Children\u2019s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada"},{"name":"Women\u2019s Health Research Institute, Vancouver, BC V6H 3N1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1538","DOI":"10.1542\/peds.2010-1167","article-title":"Trends in Cause-Specific Mortality at a Canadian Outborn NICU","volume":"126","author":"Simpson","year":"2010","journal-title":"Pediatrics"},{"key":"ref_2","unstructured":"Government of Canada, S.C. 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