{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:34:32Z","timestamp":1790116472679,"version":"4.0.1"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Scabies is a parasitic infestation of the skin with high prevalence in crowded spaces. In some instances, scabies becomes the underlying factor for complicated skin-borne opportunistic pathogens infections in both children and adults. Geographic area and socio-economic factors are determinants of the endemic pattern of this disease. Currently, the treatment of scabies has been under special attention. A combination of oral therapy with Ivermectin and sulfur-based ointments are the gold standard. However, caution is required in patients with kidney impairment. The renal involvement in children with scabies is mainly caused by acute glomerulonephritis. The severity of the nephritic syndrome can lead to other complications. Also, Ivermectin possesses a nephrotoxic effect. Severe hypertension can lead to neurological complications. The aim of our case report is to present two unusual complications in brothers with scabies. We report the cases of two brothers with scabies who presented with severe skin infection that developed acute post infectious glomerulonephritis (APIGN). In addition, one of the brothers presented with posterior reversible encephalopathy syndrome (PRES). The other one developed acute tubule-interstitial acute kidney injury following Ivermectin administration. The evolution of skin lesions was favorable, and kidney function returned to normal in both brothers.<\/jats:p>","DOI":"10.3390\/children11080981","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T06:23:05Z","timestamp":1723616585000},"page":"981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acute Glomerulonephritis Following Systemic Scabies in Two Brothers"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9456-4517","authenticated-orcid":false,"given":"Flavia","family":"Chisavu","sequence":"first","affiliation":[{"name":"4th Pediatric Clinic, \u201cLouis Turcanu\u201d Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania"},{"name":"Centre for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine \u201cVictor Babes\u201d, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-5919","authenticated-orcid":false,"given":"Mihai","family":"Gafencu","sequence":"additional","affiliation":[{"name":"4th Pediatric Clinic, \u201cLouis Turcanu\u201d Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania"},{"name":"Department XI of Pediatrics\u20143rd Pediatric Discipline, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra Maria","family":"Steflea","sequence":"additional","affiliation":[{"name":"4th Pediatric Clinic, \u201cLouis Turcanu\u201d Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania"},{"name":"Department XI of Pediatrics\u20143rd Pediatric Discipline, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-5309","authenticated-orcid":false,"given":"Adrian","family":"Vaduva","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Pathology, \u201cPius Brinzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Izvernariu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, \u201cLouis Turcanu\u201d Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-0581","authenticated-orcid":false,"given":"Ramona Florina","family":"Stroescu","sequence":"additional","affiliation":[{"name":"4th Pediatric Clinic, \u201cLouis Turcanu\u201d Children\u2019s Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania"},{"name":"Department XI of Pediatrics\u20141st Pediatric Discipline, Centre for Research on Growth and Developmental Disorders in Children, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"ref_1","first-page":"201","article-title":"Scabies complicated by acute glomerulonephritis in children: 114 cases observed in two years in a pediatric service in Dakar","volume":"43","author":"Dieng","year":"1998","journal-title":"Dakar Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/tmi.12405","article-title":"Changes in the clinical and epidemiological features of group A streptococcal bacteraemia in Australia\u2019s Northern Territory","volume":"20","author":"Gear","year":"2015","journal-title":"Trop. Med. Int. Health"},{"key":"ref_3","first-page":"CD012994","article-title":"Ivermectin and permethrin for treating scabies","volume":"4","author":"Rosumeck","year":"2018","journal-title":"Cochrane Database Syst. 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