{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:13:47Z","timestamp":1790381627908,"version":"4.1.0"},"reference-count":22,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Finnish Medical Foundation","award":["3583, 5393"],"award-info":[{"award-number":["3583, 5393"]}]},{"name":"Foundation for Pediatric Research in Finland","award":["3583, 5393"],"award-info":[{"award-number":["3583, 5393"]}]},{"name":"University of Helsinki","award":["3583, 5393"],"award-info":[{"award-number":["3583, 5393"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objective: In this retrospective study, we assessed the efficacy of oral lactase in infants with lactose intolerance in terms of sex, birth weight, and interference by other medications. Methods: The study was conducted on patients aged 0\u20136 months who had been diagnosed with lactose intolerance on admission to the Department of Social Pediatrics at Dokuz Eylul University. Demographic data, the onset of symptoms, and medications used were recorded. Results: We found that 86.7% of the infants responded to lactase, with no significant differences based on sex, birth weight, or age at symptom presentation. We observed, however, that the efficacy of treatment did improve over time, thereby deriving benefits from intestinal development and adaptation. Interestingly, the response to lactase was reduced in infants receiving concomitant simethicone for colic symptoms, suggesting a potential drug interaction, while probiotics had no impact on treatment outcomes. Conclusions: We advise against using additional medications with oral lactase, pointing out a possible interaction with simethicone that might decrease the effectiveness of treatment.<\/jats:p>","DOI":"10.3390\/children11081009","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T03:43:28Z","timestamp":1724039008000},"page":"1009","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Simethicone Medication Should Be Avoided in Infants Receiving Oral Lactase Treatment"],"prefix":"10.3390","volume":"11","author":[{"given":"Ekin Say","family":"Yildirim","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Varol","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belgin","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 \u0130zmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0811-8834","authenticated-orcid":false,"given":"And","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Dokuz Eyl\u00fcl University, 35340 \u0130zmir, T\u00fcrkiye"},{"name":"Pediatric Research Center, New Children\u2019s Hospital, University of Helsinki, Helsinki University Hospital, 00290 Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.nutres.2021.02.003","article-title":"Lactose intolerance: An update on its pathogenesis, diagnosis, and treatment","volume":"89","author":"Catanzaro","year":"2021","journal-title":"Nutr. 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