{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:38:08Z","timestamp":1788813488526,"version":"build-2803163510"},"reference-count":26,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objective: This study aimed to evaluate changes in growth parameters in children diagnosed with inflammatory bowel disease (IBD). Methods: The data of children with IBD between 2010 and 2018 were retrospectively reviewed. Anthropometric measurements (height, weight, and BMI [body mass index]), and clinical and laboratory data were evaluated at diagnosis and follow-up (1st and 2nd year). Patients\u2019 growth was assessed by calculating weight-for-age, height-for-age, BMI-for-age, and growth velocity z-scores. Results: Thirty-six patients (46.2%) had Crohn\u2019s disease (CD), and 42 (53.8%) had ulcerative colitis (UC). Weight-for-age, height-for-age, and BMI-for-age z-scores significantly increased over the follow-up period in the CD patients (p &lt; 0.05). Growth velocity z-scores were also significantly higher in the second year compared to the first year in the CD patients (p &lt; 0.001). Improvements in weight-for-age, height-for-age, and BMI-for-age z-scores were not significant over the two-year follow-up in the UC patients (p &gt; 0.05). Growth velocity z-scores in the UC patients were higher in the second year compared to the first year, but this difference was not significant (p = 0.115). Conclusions: The growth parameters showed improvement after a two-year follow-up. Regular anthropometric measurements, along with clinical and laboratory markers, should be used to monitor treatment response, which can help achieve optimal growth in children with IBD.<\/jats:p>","DOI":"10.3390\/children11091038","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T01:48:49Z","timestamp":1724636929000},"page":"1038","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Growth in Children with Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"11","author":[{"given":"U\u011fur","family":"Alta\u015f","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Marmara University, Istanbul 34899, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Ertem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Gastroenterology Hepatology and Nutrition, Faculty of Medicine, Marmara University, Pendik, Istanbul 34899, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.rdc.2013.03.010","article-title":"Update in pediatric inflammatory bowel disease","volume":"39","author":"Rabizadeh","year":"2013","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"ref_2","first-page":"904307","article-title":"Incidence and paris classification of pediatric inflammatory bowel disease","volume":"2014","author":"Papp","year":"2014","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Loddo, I., and Romano, C. (2015). Inflammatory bowel disease: Genetics, epigenetics, and pathogenesis. Front. Immunol., 6.","DOI":"10.3389\/fimmu.2015.00551"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Amaro, F., and Chiarelli, F. (2020). Growth and puberty in children with inflammatory bowel diseases. Biomedicines, 11.","DOI":"10.3390\/biomedicines8110458"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/ibd.20115","article-title":"Growth retardation in pediatric Crohn\u2019s disease: Pathogenesis and interventions","volume":"13","author":"Shamir","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.21037\/tp.2018.12.04","article-title":"Growth failure in pediatric onset inflammatory bowel disease: Mechanisms, epidemiology, and management","volume":"8","author":"Ishige","year":"2019","journal-title":"Transl. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jpeds.2007.04.004","article-title":"Body mass index in children with newly diagnosed inflammatory bowel disease: Observations from two multicenter North American inception cohorts","volume":"151","author":"Kugathasan","year":"2007","journal-title":"J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/MPG.0000000000001177","article-title":"Growth pattern in pediatric Crohn disease is related to inflammatory status","volume":"63","author":"Ley","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5009\/gnl220421","article-title":"Factors associated with reaching mid-parental height in patients diagnosed with inflammatory bowel disease in childhood and adolescent period","volume":"18","author":"Choi","year":"2024","journal-title":"Gut Liver"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pivac, I., Jelicic Kadic, A., Despot, R., Zitko, V., Tudor, D., Runjic, E., and Markic, J. (2023). Characteristics of the Inflammatory Bowel Disease in Children: A Croatian Single-Centre Retrospective Study. Children, 10.","DOI":"10.3390\/children10101677"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1586\/egh.10.23","article-title":"Nutritional considerations in pediatric inflammatory bowel disease","volume":"4","author":"Conklin","year":"2010","journal-title":"Expert. Rev. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3390\/pediatric16030051","article-title":"Acquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review","volume":"16","author":"Bellini","year":"2024","journal-title":"Pediatr. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrgastro.2014.102","article-title":"Growth problems in children with IBD","volume":"11","author":"Sanderson","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_14","unstructured":"Geneva, S. (2024, May 03). Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. Vitamin and Mineral Nutrition Information System. Document Reference WHO. NMH\/NHD\/MNM\/11.1. Available online: https:\/\/www.who.int\/publications\/i\/item\/WHO-NMH-NHD-MNM-11.1."},{"key":"ref_15","unstructured":"WHO (2024, June 03). 2009 Growth Reference Data. Available online: http:\/\/www.who.int\/growthref\/tools\/en\/."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1210\/jc.2013-4455","article-title":"Age-based reference ranges for annual height velocity in US children","volume":"99","author":"Kelly","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","first-page":"439","article-title":"Development and validation of a pediatric Crohn\u2019s disease activity index","volume":"12","author":"Hyams","year":"1991","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1053\/j.gastro.2007.05.029","article-title":"Development, validation, and evaluation of a pediatric ulcerative colitis activity index: A prospective multicenter study","volume":"133","author":"Turner","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1542\/peds.2004-0417","article-title":"Pediatric Crohn\u2019s disease and growth retardation: The role of genotype, phenotype, and disease severity","volume":"114","author":"Wine","year":"2004","journal-title":"Pediatrics"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Jin, H.Y., Lim, J.S., Lee, Y., Choi, Y., Oh, S.H., Kim, K.M., Yoo, H.W., and Choi, J.H. (2021). Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease. BMC Pediatr., 21.","DOI":"10.1186\/s12887-021-02496-4"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bpg.2004.01.002","article-title":"Specificities of inflammatory bowel disease in childhood","volume":"18","author":"Griffiths","year":"2004","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000369457","article-title":"A prospective longitudinal study of growth and pubertal progress in adolescents with inflammatory bowel disease","volume":"83","author":"Mason","year":"2015","journal-title":"Horm. Res. Paediatr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000329991","article-title":"Impact of inflammatory bowel disease on pubertal growth","volume":"76","author":"Mason","year":"2011","journal-title":"Horm. Res. Paediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MPG.0000000000001132","article-title":"Pediatric Crohn disease: Disease activity and growth in the BELCRO cohort after 3 years follow-up","volume":"63","author":"Hoffman","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/MPG.0000000000001379","article-title":"Disease status and pubertal stage predict improved growth in antitumor necrosis factor therapy for pediatric inflammatory bowel disease","volume":"64","author":"Cameron","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/archdischild-2011-300771","article-title":"Growth in children receiving contemporary disease-specific therapy for Crohn\u2019s disease","volume":"97","author":"Malik","year":"2012","journal-title":"Arch. Dis. Child."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/9\/1038\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:42:22Z","timestamp":1760110942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/9\/1038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,25]]},"references-count":26,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["children11091038"],"URL":"https:\/\/doi.org\/10.3390\/children11091038","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,25]]}}}