{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:08:08Z","timestamp":1776272888953,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: The aim is to assess the association between the level of vitamin D, maternal diseases, and macrosomia in newborns. Methods: This study included 258 full-term newborns (86 newborns with macrosomia; and 172 newborns with normal weight). Enzyme immunoassays for the determination of vitamin D were performed. Results: Newborns with macrosomia were statistically significantly more likely to have severe vitamin D deficiency compared with control (13.5 \u00b1 6.7 ng\/mL vs. 21.3 \u00b1 12.1 ng\/mL; p &lt; 0.05). In the main group, severe deficiency was found in 40.7% of newborns, in the control group this rate was 5.8% (\u03c72 = 71,788, df = 3, p &lt; 0.001). Multiple regression analysis shows that statistically significant risk factors for the development of macrosomia were vitamin D deficiency in the cord blood (OR = 2.29), maternal age over 36 years old (OR = 19.54), and hypothyroidism (OR = 9.35). Conclusion: the results of our study demonstrate relationship between macrosomia in newborns and vitamin D deficiency in the cord blood, maternal overweight and obesity, maternal age and thyroid disease.<\/jats:p>","DOI":"10.3390\/children11101160","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T04:01:24Z","timestamp":1727236884000},"page":"1160","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin D Deficiency and Maternal Diseases as Risk Factors for the Development of Macrosomia in Newborns"],"prefix":"10.3390","volume":"11","author":[{"given":"Nazym","family":"Ailbayeva","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Medical Rehabilitation Named after Tusupova D.M., Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliya","family":"Alimbayeva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Medical Rehabilitation Named after Tusupova D.M., Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oxana","family":"Yurkovskaya","sequence":"additional","affiliation":[{"name":"Department of General Medical Practice, Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raida","family":"Faizova","sequence":"additional","affiliation":[{"name":"Department of General Medical Practice, Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayat","family":"Tanatarov","sequence":"additional","affiliation":[{"name":"Center for Nuclear Medicine and Oncology, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulnara","family":"Taiorazova","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Medical Rehabilitation Named after Tusupova D.M., Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aizhan","family":"Abylgazinova","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Medical Rehabilitation Named after Tusupova D.M., Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Orekhov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulzhan","family":"Jamedinova","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Department, Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyudmila","family":"Pivina","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Semey Medical University, Semey 071400, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/jog.12209","article-title":"Factors influencing macrosomia in pregnant women in a tertiary care hospital in Malaysia","volume":"40","author":"Yadav","year":"2014","journal-title":"J. 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