{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:31:00Z","timestamp":1760146260838,"version":"build-2065373602"},"reference-count":15,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Crohn\u2019s disease (CD) is a chronic inflammatory bowel condition with increasing global incidence. Diagnosing CD is challenging and requires close collaboration between clinicians and pathologists due to the lack of specific diagnostic criteria. Histologically, CD is characterized by transmural inflammation, crypt distortion, metaplasia, and granulomas, although granulomas are not always present. Schaumann bodies (SB), initially described in sarcoidosis, are rare in CD but have been reported in about 10% of cases. This case report presents a 4-year-old female with chronic hemorrhagic diarrhea, severe anemia, and elevated inflammatory markers. Endoscopic and histological evaluations suggested CD, with the presence of SB in the gastric mucosa. Further investigations ruled out sarcoidosis, confirming a diagnosis of multi-segmental, very early onset CD with atypical histological features. SB are inclusions composed of calcium carbonate crystals and conchoid bodies, typically found within giant cells. The presence of SB in the mucosa is rare, limiting their diagnostic significance in endoscopic biopsies. Differential diagnosis should exclude other granulomatous diseases such as intestinal tuberculosis and sarcoidosis. This case highlights the importance of considering SB in the diagnosis of CD, particularly in pediatric patients.<\/jats:p>","DOI":"10.3390\/children11101216","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T06:23:18Z","timestamp":1728282198000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The First Case of Schaumann Bodies in Pediatric Very Early Onset Crohn\u2019s Disease: Case Report and Literature Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3424-4623","authenticated-orcid":false,"given":"Jovan","family":"Jevti\u0107","sequence":"first","affiliation":[{"name":"Institute of Pathology \u2018Prof. Dr. \u0110or\u0111e Joannovi\u0107\u2019, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-7380","authenticated-orcid":false,"given":"Milo\u0161","family":"\u0110ukni\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology \u2018Prof. Dr. \u0110or\u0111e Joannovi\u0107\u2019, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevena","family":"Popovac","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital Tir\u0161ova, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Risti\u0107","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital Tir\u0161ova, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Milovanovich","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital Tir\u0161ova, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Radusinovi\u0107","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital Tir\u0161ova, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"\u0110ordji\u0107","sequence":"additional","affiliation":[{"name":"University Children\u2019s Hospital Tir\u0161ova, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljubica","family":"Simi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology \u2018Prof. Dr. \u0110or\u0111e Joannovi\u0107\u2019, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-3389","authenticated-orcid":false,"given":"Gorana","family":"Nikoli\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology \u2018Prof. Dr. \u0110or\u0111e Joannovi\u0107\u2019, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"\u017divoti\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology \u2018Prof. Dr. \u0110or\u0111e Joannovi\u0107\u2019, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5083-7457","authenticated-orcid":false,"given":"Ana","family":"Mioljevi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology \u2018Prof. Dr. \u0110or\u0111e Joannovi\u0107\u2019, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Bogosavljevi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Orthopedic Surgery \u201cBanjica\u201d, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-9505","authenticated-orcid":false,"given":"Radmila","family":"Jankovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pathology \u2018Prof. Dr. \u0110or\u0111e Joannovi\u0107\u2019, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pasternak, G., Chrzanowski, G., Aebisher, D., My\u015bliwiec, A., Dynarowicz, K., Bartusik-Aebisher, D., Sosna, B., Cie\u015blar, G., Kawczyk-Krupka, A., and Filip, R. 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