{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:03:25Z","timestamp":1791205405643,"version":"4.1.0"},"reference-count":37,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea University Ansan Hospital","award":["K2409181"],"award-info":[{"award-number":["K2409181"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Perforated appendicitis in children is a frequently encountered and significant surgical condition. The treatment of choice is laparoscopic appendectomy, but this carries a risk of postoperative intra-abdominal abscess (IAA). The purpose of this study was to determine risk factors linked to the occurrence of IAA following laparoscopic surgery in pediatric perforated appendicitis. Methods: This retrospective cohort study analyzed 137 children with perforated appendicitis who received laparoscopic appendectomy at four tertiary hospitals between March 2018 and December 2022. Data on patient demographics, preoperative clinical characteristics, and surgical details were collected. Independent risk factors for IAA formation were determined using logistic regression analysis. Results: The overall incidence of postoperative IAA was 10.9%. Prolonged symptom duration and elevated CRP levels were associated with higher IAA rates. Patients who developed IAAs experienced prolonged postoperative fevers and longer hospital stays. Significant risk factors for IAA identified through multivariable analysis included a higher severity grade of appendicitis (\u2265Grade IV, OR 5.9, p = 0.034) and the presence of a free appendicolith during surgery (OR 5.549, p = 0.01). Of the patients who developed IAAs, nine (60%) improved with conservative treatment, while six (40%) required invasive procedures. Conclusions: A higher severity grade of appendicitis (\u2265Grade IV) and the presence of a free appendicolith are significant predictors of postoperative IAAs in pediatric perforated appendicitis. Recognizing these factors can help guide clinical management and postoperative care, potentially reducing the incidence of this complication.<\/jats:p>","DOI":"10.3390\/children11111385","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T12:04:25Z","timestamp":1731585865000},"page":"1385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Risk Factors for Postoperative Intra-Abdominal Abscess in Pediatric Perforated Appendicitis Following Laparoscopic Appendectomy: A Multicenter Analysis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-5413","authenticated-orcid":false,"given":"Joonhyuk","family":"Son","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Hanyang University College of Medicine, Seoul 04763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Won","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-0869","authenticated-orcid":false,"given":"Chaeyoun","family":"Oh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Department of Surgery, Korea University College of Medicine, Korea University Ansan Hospital, Ansan 15355, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13017-020-00306-3","article-title":"Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines","volume":"15","author":"Podda","year":"2020","journal-title":"World J. Emerg. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jpedsurg.2022.12.009","article-title":"Nationwide management of perforated pediatric appendicitis: Interval versus same-admission appendectomy","volume":"58","author":"Huerta","year":"2023","journal-title":"J. Pediatr. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/bjs.11298","article-title":"Nationwide study of appendicitis in children","volume":"106","author":"Omling","year":"2019","journal-title":"Br. J. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5114\/wiitm.2021.103942","article-title":"Comparison of intra-abdominal abscess formation after laparoscopic and open appendectomy for complicated and uncomplicated appendicitis: A retrospective study","volume":"16","author":"Mulita","year":"2021","journal-title":"Videosurgery Other Miniinvasive Tech."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00383-016-3990-2","article-title":"Pediatric appendicitis: State of the art review","volume":"33","author":"Rentea","year":"2017","journal-title":"Pediatr. Surg. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.jpedsurg.2012.07.066","article-title":"Laparoscopic appendectomy for perforated appendicitis in children has complication rates comparable with those of open appendectomy","volume":"48","author":"Vahdad","year":"2013","journal-title":"J. Pediatr. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000313480507100101","article-title":"Efficacy of laparoscopic appendectomy in appendicitis with peritonitis","volume":"71","author":"Mancini","year":"2005","journal-title":"Am. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jss.2009.06.033","article-title":"Laparoscopic versus open appendectomy in children: Outcomes comparison based on a statewide analysis","volume":"161","author":"Jen","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00464-005-0342-z","article-title":"Laparoscopic appendectomy for perforated appendicitis: A comparison with open appendectomy","volume":"20","author":"Yagmurlu","year":"2006","journal-title":"Surg. Endosc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/000313480407000303","article-title":"Laparoscopic appendectomy in children: Technically feasible and safe in all stages of acute appendicitis","volume":"70","author":"Vegunta","year":"2004","journal-title":"Am. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Van Amstel, P., The, S.M.L., Mulder, I.M., Bakx, R., Derikx, J.P.M., van Schuppen, J., de Vries, R., van der Kuip, M., Zijp, G.W., and Allema, J.H. (2022). The Management of Post-appendectomy Abscess in Children; A Historical Cohort Study and Update of the Literature. Front. Pediatr., 10.","DOI":"10.3389\/fped.2022.908485"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00383-015-3677-0","article-title":"The impact of disease severity, age and surgical approach on the outcome of acute appendicitis in children","volume":"31","author":"Gorter","year":"2015","journal-title":"Pediatr. Surg. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1016\/j.jpedsurg.2008.08.051","article-title":"An evidence-based definition for perforated appendicitis derived from a prospective randomized trial","volume":"43","author":"Sharp","year":"2008","journal-title":"J. Pediatr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00383-014-3617-4","article-title":"Determinants of postoperative abscess occurrence and percutaneous drainage in children with perforated appendicitis","volume":"30","author":"Emil","year":"2014","journal-title":"Pediatr. Surg. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/TA.0000000000001127","article-title":"The American Association for the Surgery of Trauma grading scale for 16 emergency general surgery conditions: Disease-specific criteria characterizing anatomic severity grading","volume":"81","author":"Tominaga","year":"2016","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00383-013-3262-3","article-title":"To drain or not to drain: An analysis of abscess drains in the treatment of appendicitis with abscess","volume":"29","author":"Gasior","year":"2013","journal-title":"Pediatr. Surg. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/SLA.0000000000002188","article-title":"The Global Incidence of Appendicitis: A Systematic Review of Population-based Studies","volume":"266","author":"Ferris","year":"2017","journal-title":"Ann. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.3346\/jkms.2021.36.e116","article-title":"Analysis of Pediatric Surgery Using the National Healthcare Insurance Service Database in Korea: How Many Pediatric Surgeons Do We Need in Korea?","volume":"36","author":"Oh","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1053\/jpsu.2003.50111","article-title":"Appendicitis 2000: Variability in practice, outcomes, and resource utilization at thirty pediatric hospitals","volume":"38","author":"Newman","year":"2003","journal-title":"J. Pediatr. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jamcollsurg.2017.12.046","article-title":"Appendicitis Grade, Operative Duration, and Hospital Cost","volume":"226","author":"Collins","year":"2018","journal-title":"J. Am. Coll. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s11605-012-1962-y","article-title":"Laparoscopic versus open appendectomy for complicated and uncomplicated appendicitis in children","volume":"16","author":"Markar","year":"2012","journal-title":"J. Gastrointest. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.sla.0000193602.74417.14","article-title":"Laparoscopic versus open appendectomy in children: A meta-analysis","volume":"243","author":"Aziz","year":"2006","journal-title":"Ann. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jss.2019.09.031","article-title":"Pediatric Appendicitis-Factors Associated With Surgical Approach, Complications, and Readmission","volume":"246","author":"Inagaki","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jpedsurg.2011.11.023","article-title":"Comparison of intraabdominal abscess formation after laparoscopic and open appendicectomies in children","volume":"47","author":"Nataraja","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1007\/s00330-023-10273-3","article-title":"CT of appendicoliths in adult appendicitis: Clinical significance and characteristics of overlooked cases","volume":"34","author":"Kaewlai","year":"2024","journal-title":"Eur. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109165","DOI":"10.1016\/j.ejrad.2020.109165","article-title":"Imaging of appendicitis: Tips and tricks","volume":"130","author":"Monsonis","year":"2020","journal-title":"Eur. J. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2214\/AJR.12.9801","article-title":"Ultrasound for differentiation between perforated and nonperforated appendicitis in pediatric patients","volume":"200","author":"Blumfield","year":"2013","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jss.2018.03.012","article-title":"Can ultrasound reliably identify complicated appendicitis in children?","volume":"229","author":"Gonzalez","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2214\/ajr.175.4.1750981","article-title":"Appendicolith revealed on CT in children with suspected appendicitis: How specific is it in the diagnosis of appendicitis?","volume":"175","author":"Lowe","year":"2000","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2214\/AJR.07.2917","article-title":"Dropped appendicolith: CT findings and implications for management","volume":"190","author":"Singh","year":"2008","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00247-014-3247-y","article-title":"The \u2018wandering appendicolith\u2019","volume":"45","author":"Betancourt","year":"2015","journal-title":"Pediatr. Radiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e18047","DOI":"10.1097\/MD.0000000000018047","article-title":"Peritoneal irrigation vs suction alone during pediatric appendectomy for perforated appendicitis: A meta-analysis","volume":"98","author":"Bi","year":"2019","journal-title":"Medicine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1089\/lap.2018.0061","article-title":"Infectious Complications After Laparoscopic Appendectomy in Pediatric Patients with Perforated Appendicitis: Is There a Difference in the Outcome Using Irrigation and Suction Versus Suction Only? Results of a Multicentric International Retrospective Study","volume":"28","author":"Escolino","year":"2018","journal-title":"J. Laparoendosc. Adv. Surg. Tech."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.jpedsurg.2007.07.013","article-title":"Is peritoneal drainage necessary in childhood perforated appendicitis?--a comparative study","volume":"42","author":"Narci","year":"2007","journal-title":"J. Pediatr. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jss.2020.05.082","article-title":"Oral Antibiotics and Abscess Formation After Appendectomy for Perforated Appendicitis in Children","volume":"256","author":"Gordon","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jss.2020.05.016","article-title":"Intra-abdominal Abscess After Appendectomy-Are Drains Necessary in All Patients?","volume":"254","author":"Svetanoff","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jss.2015.03.089","article-title":"Postoperative timing of computed tomography scans for abscess in pediatric appendicitis","volume":"200","author":"Nielsen","year":"2016","journal-title":"J. Surg. Res."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/11\/1385\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:32:38Z","timestamp":1760113958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/11\/11\/1385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":37,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["children11111385"],"URL":"https:\/\/doi.org\/10.3390\/children11111385","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]}}}