{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:39:47Z","timestamp":1780105187593,"version":"3.54.0"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Research Support of the State of S\u00e3o Paulo (FAPESP)","award":["2022\/13478-2"],"award-info":[{"award-number":["2022\/13478-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Introduction: Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a new member of the coronavirus family. While respiratory transmission is the main route, concerns have arisen regarding possible vertical transmission, which refers to the transmission of the virus from mother to fetus through the dissemination of viral particles in the amniotic fluid. Fetal viral infection via the placenta can affect the formation of the auditory system and lead to congenital hearing disorders. The aim of this research was to investigate the effects of vertical exposure to COVID-19 on the auditory system of newborns. Methodology: The study included a study group (SG) and a control group (CG). Selected during neonatal hearing screening, the SG consisted of 23 infants up to 1 year old whose mothers had been infected with SARS-CoV-2. The CG consisted of 15 infants whose mothers became pregnant after the end of the pandemic, had tested negative for COVID-19, and had no respiratory symptoms during pregnancy. The assessments for both groups were brainstem auditory evoked potentials (BAEPs), tympanometry, transient evoked otoacoustic emissions (TEOAEs), and distortion product otoacoustic emissions (DPOAEs). The research was divided into two studies, one cross-sectional and the other longitudinal. Results: All participants exhibited absolute latencies within the normal range for waves I, III, and V, although in the SG, there was a statistically significant increase in the latency of wave I in the left ear. In terms of OAEs, in the SG, there appeared to be a tendency for TEOAEs to be absent at high frequencies. Over several months, there was a general decrease in the amplitude of high-frequency responses in both TEOAEs and DPOAEs. Conclusion: No evidence was found that vertical exposure to COVID-19 causes hearing loss, although there were signs of possible deterioration in hair cell functioning.<\/jats:p>","DOI":"10.3390\/children11121527","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T12:09:28Z","timestamp":1734350968000},"page":"1527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the Peripheral and Central Auditory System in Infants Whose Mothers Tested Positive for COVID-19 During Pregnancy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7807-3355","authenticated-orcid":false,"given":"Jheniffer Queiroz","family":"Raimundo","sequence":"first","affiliation":[{"name":"School of Medical Sciences, State University of Campinas, Campinas 13083-887, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3647-3999","authenticated-orcid":false,"given":"Milaine Dominici","family":"Sanfins","sequence":"additional","affiliation":[{"name":"Department of Speech-Hearing-Language, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04044-020, Brazil"},{"name":"Post-Graduate Program in Clinical Audiology, Instituto de Ensino e Pesquisa Albert Einstein, S\u00e3o Paulo 05652-000, Brazil"},{"name":"Department of Teleaudiology and Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, 05-830 Kajetany, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-1915","authenticated-orcid":false,"given":"Piotr Henryk","family":"Skarzynski","sequence":"additional","affiliation":[{"name":"Department of Teleaudiology and Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, 05-830 Kajetany, Poland"},{"name":"ENT Department, Maria Curie-Sk\u0142odowska University, 20-031 Lublin, Poland"},{"name":"Center of Hearing and Speech Medincus, 05-830 Kajetany, Poland"},{"name":"Department of Otolaryngology, Institute of Sensory Organs, 05-830 Warsaw, Poland"},{"name":"Heart Failure and Cardiac Rehabilitation Department, Medical University of Warsaw, 02-091 Warsaw, Poland"},{"name":"World Hearing Center, 05-830 Kajetany, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-1698","authenticated-orcid":false,"given":"Magdalena Beata","family":"Skar\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Pharmaceutical Care, Medical University of Warsaw, 02-091 Warsaw, Poland"},{"name":"Institute of Sensory Organs, 05-830 Kajetany, Poland"},{"name":"Center of Hearing and Speech, 05-830 Nadarzyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7456-9502","authenticated-orcid":false,"given":"Maria Francisca","family":"Colella-Santos","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, State University of Campinas, Campinas 13083-887, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/ijpvm.IJPVM_144_20","article-title":"COVID-19 outbreak in international airport\u2014Where the incidence case occurs?","volume":"11","author":"Sriwijitalai","year":"2020","journal-title":"Int. J. Prev. Med."},{"key":"ref_2","first-page":"284","article-title":"Perinatal SARS-CoV-2 Infection and Neonatal COVID-19: A 2021 Update","volume":"22","author":"Sankaran","year":"2021","journal-title":"Neo Rev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics, and Joint Committee on Infant Hearing (2007). Year 2019 position statement: Principles and guidelines for early hearing detection and intervention programs. Pediatrics, 120, 898\u2013921.","DOI":"10.1542\/peds.2007-2333"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gonik, L., Oliveira, A.T.D.F., Chagas, P.S.C., and Fr\u00f4nio, J.D.S. (2021). Auditory and Language Development Assessment of Newborns Aged One to Four Years Exposed to Gestational Zika Virus Infection: A Case Series. Int. J. Env. Res. Public Health, 18.","DOI":"10.3390\/ijerph18126562"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bjorl.2019.05.002","article-title":"Auditory findings associated with Zika virus infection: An integrative review","volume":"85","author":"Barbosa","year":"2019","journal-title":"Braz. J Otorhinolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102982","DOI":"10.1016\/j.amjoto.2021.102982","article-title":"Evaluation of cochlear functions in infants exposed to SARS-CoV-2 intrauterine","volume":"42","author":"Celik","year":"2021","journal-title":"Am. J. Otolaryngol."},{"key":"ref_7","first-page":"727","article-title":"Evaluation of middle ear function in young children: Clinical guidelines for the use of 226- and 1000-Hz tympanometry","volume":"28","author":"Alaerts","year":"2007","journal-title":"Int. J. Otorhinolaryngol."},{"key":"ref_8","unstructured":"Dhar, S., and Hall, J.W. (2018). Otoacoustic Emissions Principles, Procedures and Protocols, Plural Publishing. [2nd ed.]."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.ijporl.2015.06.028","article-title":"Criteria for detection of transiently evoked otoacoustic emissions in schoolchildren","volume":"79","author":"Trzaskowski","year":"2015","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1044\/jshr.3202.281","article-title":"Auditory brainstem responses from children three months to three years of age: II. Normal patterns of response","volume":"32","author":"Gorga","year":"1989","journal-title":"J. Speech Hear. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"110801","DOI":"10.1016\/j.ijporl.2021.110801","article-title":"Intrauterine exposure to Zika virus and hearing loss within the first few years of life: A systematic literature review","volume":"147","author":"Mitsikas","year":"2021","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103379","DOI":"10.1016\/j.amjoto.2022.103379","article-title":"Auditory evaluation of infants born to COVID19 positive mothers","volume":"43","author":"Ghiselli","year":"2022","journal-title":"Am. J. Otolaryngol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Apa, E., Presutti, M.T., Rossi, C., Roversi, M.F., Neri, S., Gargano, G., Bianchin, G., Polizzi, V., Caragli, V., and Monzani, D. (2023). Monitoring of Auditory Function in Newborns of Women Infected by SARS-CoV-2 during Pregnancy. Children, 10.","DOI":"10.3390\/children10020194"},{"key":"ref_14","first-page":"e25571","article-title":"Hearing outcomes of infants born to mothers with active COVID-19 infection","volume":"14","author":"Panagiota","year":"2022","journal-title":"Cureus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00431-022-04770-8","article-title":"Hearing screening test in neonates born to COVID-19\u2013positive mothers","volume":"182","author":"Goulioumis","year":"2023","journal-title":"Eur. J. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/AUD.0000000000001167","article-title":"Newborn hearing screening results of infants born to mothers who had COVID-19 disease during pregnancy: A retrospective cohort study","volume":"43","author":"Buyuk","year":"2022","journal-title":"Ear Hear."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jog.15008","article-title":"Hearing test results of newborns born from the coronavirus disease 2019 (COVID-19) infected mothers: A tertiary center experience in Turkey","volume":"48","author":"Kurt","year":"2022","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Malesci, R., Rizzo, D., Del Vecchio, V., Serra, N., Tarallo, G., D\u2019Errico, D., Coronella, V., Bussu, F., Vecchio, A.L., and Auletta, G. (2022). The Absence of Permanent Sensorineural Hearing Loss in a Cohort of Children with SARS-CoV-2 Infection and the Importance of Performing the Audiological \u201cWork-Up\u201d. Children, 9.","DOI":"10.3390\/children9111681"},{"key":"ref_19","first-page":"28","article-title":"Hearing function in children after new coronavirus infection (COVID-19)","volume":"86","author":"Tufatulin","year":"2021","journal-title":"Vestn. Otorinolaringol."},{"key":"ref_20","unstructured":"Hall, J.W. (2006). New Handbook for Auditory Evoked Responses, Pearson Education."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110754","DOI":"10.1016\/j.ijporl.2021.110754","article-title":"Hearing screening outcomes in neonates of SARS-CoV-2 positive pregnant women","volume":"146","author":"Alan","year":"2021","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.heares.2005.12.003","article-title":"Lateral asymmetry in the ABR of neonates: Evidence and mechanisms","volume":"212","author":"Sininger","year":"2006","journal-title":"Hear. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1007\/s00405-021-07098-5","article-title":"Maternal COVID-19 and neonatal hearing loss: A multicentric survey","volume":"279","author":"Mostafa","year":"2022","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102483","DOI":"10.1016\/j.amjoto.2020.102483","article-title":"Audiological profile of asymptomatic Covid-19 PCR-positive cases","volume":"41","author":"Mustafa","year":"2020","journal-title":"Am. J. Otolaryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MAO.0000000000003761","article-title":"Is Gestational COVID-19 a Risk Factor for Congenital Hearing Loss?","volume":"44","author":"Toker","year":"2023","journal-title":"Otol. Neurotol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"103859","DOI":"10.1016\/j.amjoto.2023.103859","article-title":"Is intrauterine exposure to COVID-19 infection a risk factor for infant hearing loss?","volume":"44","author":"Kirbac","year":"2023","journal-title":"Am. J. Otolaryngol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.15537\/smj.2022.43.3.20210782","article-title":"Does SARS-CoV-2 affect cochlear functions in children?","volume":"43","author":"Koca","year":"2022","journal-title":"Saudi Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-5955(96)00178-5","article-title":"Auditory threshold sensitivity of the human neonate as measured by the auditory brainstem response","volume":"104","author":"Sininger","year":"1997","journal-title":"Hear. Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Li, M., Chen, L., Zhang, J., Xiong, C., and Li, X. (2020). The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by singlecell transcriptome study. PLoS ONE, 15.","DOI":"10.1101\/2020.02.27.967760"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/biologics1030021","article-title":"A Comprehensive Overview of the Newly Emerged COVID-19 Pandemic: Features, Origin, Genomics, Epidemiology, Treatment, and Prevention","volume":"1","author":"Sarker","year":"2021","journal-title":"Biologics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1055\/s-0040-1722256","article-title":"Vertical Transmission of SARS-CoV-2: A Systematic Review","volume":"43","author":"Barcelos","year":"2021","journal-title":"Rev. Bras. Ginecol. Obstet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e2215787","DOI":"10.1001\/jamanetworkopen.2022.15787","article-title":"Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy","volume":"5","author":"Edlow","year":"2022","journal-title":"JAMA Netw. 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