{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:05:08Z","timestamp":1792019108280,"version":"4.4.0"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY22H100007"],"award-info":[{"award-number":["LY22H100007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Feeding intolerance (FI) following surgery for neonatal necrotizing enterocolitis (NEC) can impact recovery and prognosis, making the early identification of FI risk essential for optimizing management and improving outcomes. Methods: We retrospectively collected data from patients who underwent surgery for NEC between January 2013 and December 2023. Multivariate binary logistic regression was performed to identify independent factors influencing postoperative feeding intolerance. Results: Of the 519 infants enrolled in this retrospective study, 155 (29.9%) were diagnosed with feeding intolerance, while 364 (70.1%) were identified as having feeding tolerance. Compared to infants with feeding tolerance, those with feeding intolerance had lower birth weight, smaller gestational age, and lower Apgar scores (all p &lt; 0.01). A 5 min Apgar &lt; 7 (OR 4.794; 95%CI 1.339\u201317.156), the interval between diagnosis and surgery (OR 0.973; 95%CI 0.947\u20131.000), and primary anastomosis resection (OR 0.278, 95%CI 0.139\u20130.555) were identified as significant factors influencing postoperative feeding intolerance. The results remained consistent after performing propensity score matching analysis. Feeding intolerance may result in prolonged hospital stays, and more complications such as retinopathy of prematurity, intestinal failure-associated liver disease, and intraventricular hemorrhage. Conclusions: A lower 5 min Apgar score, shorter interval from diagnosis to surgery and intestine resection with ostomy are associated with a higher incidence of FI after surgery. FI after NEC surgery can prolong recovery and increase family burden.<\/jats:p>","DOI":"10.3390\/children12020127","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T06:17:52Z","timestamp":1737699472000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Characteristics and Influencing Factors of Feeding Intolerance After Surgery for Neonatal Necrotizing Enterocolitis"],"prefix":"10.3390","volume":"12","author":[{"given":"Mengting","family":"Hu","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikai","family":"Fu","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Ju","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Ma","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"},{"name":"Department of Pulmonology, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Children\u2019s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China"},{"name":"National Clinical Research Center for Child Health, National Children\u2019s Regional Medical Center, Hangzhou 310052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s40272-024-00626-w","article-title":"Neonatal Necrotizing Enterocolitis: An Update on Pathophysiology, Treatment, and Prevention","volume":"26","author":"Roberts","year":"2024","journal-title":"Paediatr. 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