{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:52:18Z","timestamp":1766400738181,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: This study investigates the incidence of acute alcohol intoxication (AAI) in adolescents in Belgium, by comparing nationwide estimations based on health insurance data with a recently published hospital chart study in Antwerp. In this way, the scope of AAI among adolescents in Belgium can be estimated more precisely. Methods: Health insurance data collected by the Intermutualistic Agency (IMA) regarding 12- to 17-year-olds admitted at emergency departments in Antwerp in 2019\u20132021 and receiving a blood test to screen for blood alcohol concentration were validated by data derived from a recently conducted retrospective hospital chart study regarding AAI among adolescents in Antwerp. To compare the incidence of adolescents with AAI between these two datasets, a Poisson regression analysis was performed. Results: The findings reveal that the approximations based on administrative health insurance data present a significant underestimation of the incidence of AAI (p &lt; 0.001): the number of admissions in Antwerp determined by the hospital chart study was 21% higher over 2019\u20132021. Correcting for this underestimation reveals an estimation for the nationwide average yearly incidence of AAI admissions among adolescents of 33.5 per 10,000 instead of 27.7 per 10,000 in Belgium over 2019\u20132021. Conclusions: These results imply that the occurrence of AAI among Belgian youth is larger than previously estimated. Therefore, a higher fraction of Belgian adolescents are at risk of serious health consequences due to AAI. This underlines the importance of the development of effective intervention strategies regarding indicated prevention and follow-up.<\/jats:p>","DOI":"10.3390\/children12020214","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:53:22Z","timestamp":1739271202000},"page":"214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nationwide Incidence of Acute Alcohol Intoxication in Adolescents in Belgium: A Validation Study of Belgian Health Insurance Data Through Comparison with Retrospective Hospital Chart Data in Antwerp, Belgium"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7599-4503","authenticated-orcid":false,"given":"Hanna","family":"van Roozendaal","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stijn","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium"},{"name":"Department of Paediatrics, Antwerp University Hospital, 2650 Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3948-9862","authenticated-orcid":false,"given":"Inge","family":"Glazemakers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium"},{"name":"University Centre for Child and Adolescent Psychiatry (ZNA-UKJA), 2020 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Rygaert","sequence":"additional","affiliation":[{"name":"Intermutualistic Agency, 1210 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiel","family":"Callens","sequence":"additional","affiliation":[{"name":"EHSAL Management School, 1000 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"De Guchtenaere","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"De Dooy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium"},{"name":"Department of Paediatrics, Antwerp University Hospital, 2650 Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nico","family":"van der Lely","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium"},{"name":"Department of Paediatrics, Reinier de Graaf Hospital, 2625 AD Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4611-4076","authenticated-orcid":false,"given":"Guido","family":"Van Hal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018). Global Status Report on Alcohol and Health 2018, World Health Organization."},{"key":"ref_2","unstructured":"Inchley, J., Currie, D.B., Budisavljevic, S., Torsheim, T., Jastad, A., Cosma, A., Kelly, C., and Arnasson, A.M. (2020). Spotlight on Adolescent Health and Well-Being. Findings from the 2017\/2018 Health Behaviour in School-Aged Children (HBSC) Survey in Europe and Canada. International Report, WHO Regional Office for Europe."},{"key":"ref_3","unstructured":"Dierckens, M., Delaruelle, M., and Deforche, B. (2021). Eindrapport Studie Jongeren en Gezondheid 2017\u20132020, Ghent University Health Promotion DoPHaPC, Faculty of Medicine and Health Sciences."},{"key":"ref_4","unstructured":"Rosiers, J. (2021). Syntheserapport Leerlingenbevraging 2000\u20132019. Evoluties en Inzichten, VAD."},{"key":"ref_5","unstructured":"Rosiers, J. (2024). VAD-Leerlingenbevraging. Het Kader van een Drugbeleid op School. Syntheserapport Schooljaar 2022\u20132023, Vlaams Expertisecentrum Alcohol en Andere Drugs (VAD)."},{"key":"ref_6","first-page":"5","article-title":"Adolescent Binge Drinking","volume":"39","author":"Chung","year":"2018","journal-title":"Alcohol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.15288\/jsad.2014.75.158","article-title":"New research findings since the 2007 Surgeon General\u2019s Call to Action to Prevent and Reduce Underage Drinking: A review","volume":"75","author":"Hingson","year":"2014","journal-title":"J. Stud. Alcohol. Drugs"},{"key":"ref_8","first-page":"87","article-title":"Effects of Binge Drinking on the Developing Brain","volume":"39","author":"Jones","year":"2018","journal-title":"Alcohol Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1542\/peds.2006-1517","article-title":"Binge drinking and associated health risk behaviors among high school students","volume":"119","author":"Miller","year":"2007","journal-title":"Pediatrics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2022.08.013","article-title":"Identification and management of acute alcohol intoxication","volume":"108","author":"Mirijello","year":"2023","journal-title":"Eur. J. Intern. Med."},{"key":"ref_11","first-page":"9121","article-title":"Role of first aid in the management of acute alcohol intoxication: A narrative review","volume":"24","author":"Piccioni","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.drugalcdep.2016.02.037","article-title":"Long-term outcomes after adolescent in-patient treatment due to alcohol intoxication: A control group study","volume":"162","author":"Gross","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/add.13477","article-title":"Alcohol consumption as a cause of cancer","volume":"112","author":"Connor","year":"2017","journal-title":"Addiction"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.nicl.2014.06.011","article-title":"The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth","volume":"5","author":"Ewing","year":"2014","journal-title":"Neuroimage Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/j.1360-0443.2004.00846.x","article-title":"Teenage drinking and the onset of alcohol dependence: A cohort study over seven years","volume":"99","author":"Bonomo","year":"2004","journal-title":"Addiction"},{"key":"ref_16","unstructured":"(2006). Factsheet Alcohol, European Commission."},{"key":"ref_17","first-page":"6","article-title":"Ten Years of Alcohol Intoxication in Adolescents and Treatment in Paediatric Departments in Dutch Hospitals","volume":"1","author":"Nienhuis","year":"2017","journal-title":"J. Addict. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Trefan, L., Gartner, A., Alcock, A., Farewell, D., Morgan, J., Fone, D., and Paranjothy, S. (2019). Epidemiology of alcohol-related emergency hospital admissions in children and adolescents: An e-cohort analysis in Wales in 2006\u20132011. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217598"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Green, M.A., Strong, M., Conway, L., and Maheswaran, R. (2017). Trends in alcohol-related admissions to hospital by age, sex and socioeconomic deprivation in England, 2002\/03 to 2013\/14. BMC Public Health, 17.","DOI":"10.1186\/s12889-017-4265-0"},{"key":"ref_20","unstructured":"Metadatafiche IMA Atlas Alcoholintoxicatie (2023, August 10). Intermutualistisch Agentschap. Available online: https:\/\/atlas.ima-aim.be\/databanken\/?rw=1&lang=nl."},{"key":"ref_21","first-page":"20","article-title":"Alcoholgebruik bij jongeren in Belgi\u00eb is verontrustend","volume":"279","author":"Verniest","year":"2020","journal-title":"CM-Informatie"},{"key":"ref_22","unstructured":"Intermutualistisch Agentschap (IMA) (2019). Zes Jongeren per Dag in Het Ziekenhuis na Alcoholmisbruik [Press Release], Intermutualistisch Agentschap (IMA)."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"van Roozendaal, H., Verhulst, S., Glazemakers, I., De Meulder, F., Vander Auwera, A., Bael, A., Van Damme, E., Vlemincx, I., De Dooy, J., and van der Lely, N. (2023). Characteristics of Adolescents Admitted with Acute Alcohol Intoxication: A Retrospective Multicentre Study in Antwerp, Belgium, in the Period 2015\u20132021. Children, 10.","DOI":"10.3390\/children10081378"},{"key":"ref_24","unstructured":"(2023, August 23). Stad in Cijfers. Available online: https:\/\/stadincijfers.antwerpen.be\/viewer."},{"key":"ref_25","unstructured":"IMA-Atlas (2023, August 23). Intermutualistisch Agentschap (IMA). Available online: http:\/\/atlas.ima-aim.be."},{"key":"ref_26","unstructured":"STATBEL (2023, May 22). Belgi\u00eb in Cijfers. Available online: https:\/\/statbel.fgov.be\/nl."},{"key":"ref_27","unstructured":"Baum, C.R., Sample, J.A., and Ganetskky, M. (2023, September 01). Ethanol Intoxication in Children: Clinical Features, Evaluation, and Management. UpToDate, Wolters Kluwer. Available online: https:\/\/www.uptodate.com\/contents\/ethanol-intoxication-in-children-clinical-features-evaluation-and-management."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jadohealth.2021.07.038","article-title":"Acute Alcohol Intoxication in Dutch Adolescents Before, During, and After the First COVID-19 Lockdown","volume":"69","author":"Pigeaud","year":"2021","journal-title":"J. Adolesc. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jadohealth.2020.08.017","article-title":"Rebound of Severe Alcoholic Intoxications in Adolescents and Young Adults After COVID-19 Lockdown","volume":"67","author":"Grigoletto","year":"2020","journal-title":"J. Adolesc. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/jrh.12151","article-title":"Rural and Urban Differences in Adolescent Alcohol Use, Alcohol Supply, and Parental Drinking","volume":"32","author":"Chan","year":"2016","journal-title":"J. Rural Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s10943-018-0694-z","article-title":"The Role of Religion and Religiosity in Alcohol Consumption in Adolescents in Spain","volume":"58","author":"Meneses","year":"2019","journal-title":"J. Relig. Health"},{"key":"ref_32","unstructured":"StatLine: CBS (2023, September 01). Bevolking op Eerste van de Maand; Geslacht, Leeftijd, Migratieachtergrond. Available online: https:\/\/opendata.cbs.nl."},{"key":"ref_33","unstructured":"Inchley, J., Currie, D., Vieno, A., Torsheim, T., Ferreira-Borges, C., Weber, M., Barnekow, V., and Breda, J. (2018). Adolescent Alcohol-Related Behaviours: Trends and Inequalities in the WHO European Region, 2002\u20132014, World Health Organization (WHO)."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1111\/acer.14166","article-title":"Five-Year Incidence of Hospital-Based Emergencies Related to Acute Recreational Intoxication in Minors","volume":"43","author":"Sanvisens","year":"2019","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_35","unstructured":"Federale Overheidsdienst Volksgezondheid, Veiligheid van de Voedselketen en Leefmilieu (2023). Interfederale Strategie Inzake Schadelijk Gebruik van Alcohol 2023\u20132028. Actieplan 2023\u20132025, Federale Overheidsdienst Volksgezondheid, Veiligheid van de Voedselketen en Leefmilieu. Available online: https:\/\/overlegorganen.gezondheid.belgie.be\/sites\/default\/files\/documents\/20230329_imcvg_tvd_cimsp_rtd_1_alcoholplan_-_annexe_2.pdf."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/2\/214\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:31:09Z","timestamp":1760027469000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/2\/214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["children12020214"],"URL":"https:\/\/doi.org\/10.3390\/children12020214","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2025,2,11]]}}}