{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:52:20Z","timestamp":1760057540390,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objective: To investigate the clinical characteristics associated with the presence of LSV at birth. Design: Prospective 1:1 case\u2013control study. Setting: Two tertiary neonatal units in Athens, Greece. Patients: Premature neonates (\u226436 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected. Main outcome measure: Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided p-values were computed using the likelihood ratio test. Results: This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV. Conclusions: This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV\u2019s pathophysiological mechanisms.<\/jats:p>","DOI":"10.3390\/children12020223","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T10:25:57Z","timestamp":1739355957000},"page":"223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case\u2013Control Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Aikaterini","family":"Kyriakopoulou","sequence":"first","affiliation":[{"name":"Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyriakos","family":"Samikos","sequence":"additional","affiliation":[{"name":"Iaso Maternity Hospital, 151 23 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikaterini","family":"Kanavaki","sequence":"additional","affiliation":[{"name":"Iaso Maternity Hospital, 151 23 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-4127","authenticated-orcid":false,"given":"Efthymia","family":"Alexopoulou","sequence":"additional","affiliation":[{"name":"2nd Department of Radiology, General University Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Argyropoulou","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 455 00 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodora","family":"Psaltopoulou","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-6470","authenticated-orcid":false,"given":"Christina","family":"Kanaka-Gantenbein","sequence":"additional","affiliation":[{"name":"Diabetes Center, Division of Endocrinology, Diabetes, and Metabolism, First Department of Pediatrics, Agia Sophia Children\u2019s Hospital, National and Kapodistrian University of Athens, 115 27 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argyrios","family":"Dinopoulos","sequence":"additional","affiliation":[{"name":"Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melpomene","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0991-9198","authenticated-orcid":false,"given":"Anastasia","family":"Antoniadou","sequence":"additional","affiliation":[{"name":"Fourth Department of Medicine, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iliani","family":"Filippa","sequence":"additional","affiliation":[{"name":"Iaso Maternity Hospital, 151 23 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-143X","authenticated-orcid":false,"given":"Nikolaos","family":"Siafakas","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Laboratory, Attikon General University Hospital, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-6060","authenticated-orcid":false,"given":"Stylianos","family":"Serghiou","sequence":"additional","affiliation":[{"name":"Prolaio, Inc., Chicago, IL 60606, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassiliki","family":"Papaevangelou","sequence":"additional","affiliation":[{"name":"Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1148\/radiology.169.2.2845473","article-title":"Echogenic Vasculature in the Basal Ganglia of Neonates: A Sonographic Sign of Vasculopathy","volume":"169","author":"Teele","year":"1988","journal-title":"Radiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.earlhumdev.2015.04.005","article-title":"The Etiology of Lenticulostriate Vasculopathy and the Role of Congenital Infections","volume":"91","author":"Cantey","year":"2015","journal-title":"Early Hum. 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