{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:59:11Z","timestamp":1760057951492,"version":"build-2065373602"},"reference-count":12,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: The neonatal period has a number of characteristics leading to an increased risk of severe and, in many cases, life-threatening complications. Renal venous thrombosis is one of them. It accounts for 16\u201320% of all thromboembolisms in the neonatal period. Due to the delicate balance in coagulation status in the first days after birth, conditions such as infections, hypoxia, hypotension, and dehydration can lead to the occurrence of this complication. The incidence of renal thrombosis is 2.2\/100,000 live births, with cases of intrauterine renal thrombosis being even rarer (7% of cases). The diagnosis of the disease is usually performed using ultrasound examination and Doppler sonography, although contrast angiography is the gold standard for diagnosing these conditions. Case presentation: We present a clinical case of a male child with manifestations of diabetic fetopathy and prenatally occurring venous thrombosis of the right kidney, confirmed by ultrasound 2 h after birth. Results: The occurrence and evolution of venous thrombosis was monitored through a series of ultrasound examinations. Despite the restoration of renal blood flow after the initiation of therapy, long-term follow-up at 6 and 12 months revealed the onset of renal atrophy. Conclusions: Prenatal renal vein thrombosis is a rare but severe pathology for the newborns. Ultrasound examination is the method of first choice in cases of suspected renal vein thrombosis, as well as for renal blood flow restoration and for the monitoring of the fate of the affected kidney.<\/jats:p>","DOI":"10.3390\/children12030319","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T07:37:17Z","timestamp":1740987437000},"page":"319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Renal Vein Thrombosis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3978-044X","authenticated-orcid":false,"given":"Petya","family":"Markova","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria"},{"name":"Department of Pediatrics, University Hospital \u201cSt. George\u201d, 4000 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanka","family":"Paskaleva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria"},{"name":"Department of Pediatrics, University Hospital \u201cSt. George\u201d, 4000 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stoyan","family":"Markov","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria"},{"name":"Department of Otorhinolaryngology, University Hospital \u201cSt. George\u201d Plovdiv, 4000 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariya","family":"Neshterova","sequence":"additional","affiliation":[{"name":"Department of Neonatology, USHATOG Selena Plovdiv, 4000 Plovdiv, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref_1","unstructured":"Rayer, P. (1837). Traite des Maladies des Reins et des Alterations de la Secretion Urinaire, Bailliere."},{"key":"ref_2","first-page":"31","article-title":"Spontaneous neonatal renal vein thrombosis, a known pathology without clear management guidelines: An overview","volume":"7","year":"2020","journal-title":"Int. J. Pediatr. Adolesc. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00467-015-3160-0","article-title":"Renal vascular thrombosis in the newborn","volume":"31","author":"Resontoc","year":"2016","journal-title":"J. Ped. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/08880018.2015.1132801","article-title":"Neonatal renal vein thrombosis: Role of anticoagulation and thrombolysis\u2014An institutional review","volume":"33","author":"Bidadi","year":"2016","journal-title":"Pediatr. Hematol. 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Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e0284","DOI":"10.1097\/MD.0000000000010284","article-title":"Color Doppler ultrasound diagnosis of intrarenal vein thrombosis: A rare case report and literature review","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/BF00858135","article-title":"Neonatal renal venous thrombosis\u2014A case report describing serial sonographic changes","volume":"8","author":"Lin","year":"1994","journal-title":"Pediatr. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"F273","DOI":"10.1136\/adc.2005.083717","article-title":"Perinatal renal venous thrombosis: Presenting renal length predicts outcome","volume":"91","author":"Winyard","year":"2006","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/3\/319\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:45:12Z","timestamp":1760028312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/3\/319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["children12030319"],"URL":"https:\/\/doi.org\/10.3390\/children12030319","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2025,2,28]]}}}