{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:52:37Z","timestamp":1788357157352,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Chronic liver disease (CLD) in children poses significant challenges, necessitating timely management to mitigate morbidity and mortality. Liver transplantation (LT) has emerged as a transformative intervention, offering improved long-term survival for paediatric patients with CLD. This review explores the evolving landscape of liver transplantation, focusing on indications and timing considerations. The aetiology of CLD is diverse, encompassing intrahepatic, extrahepatic cholestatic conditions, metabolic diseases, malignancy, and drug-induced liver injury. LT is indicated when children exhibit signs of hepatic decompensation, necessitating a comprehensive evaluation to assess transplant suitability. Indications for LT include biliary atresia, inborn errors of metabolism, hepatocellular carcinoma, and emerging indications such as mitochondrial hepatopathies and acute on chronic liver failure. The timing of transplantation is critical, emphasizing the need for early recognition of decompensation signs to optimise outcomes. Advancements in LT techniques and immunosuppressive therapies have enhanced patient and graft survival rates. Various transplant modalities, including reduced-size LT and living-related LT, offer tailored solutions to address the unique needs of paediatric patients. While LT represents a cornerstone in the management of paediatric CLD, careful patient selection, multidisciplinary collaboration, and ongoing refinements in transplant protocols are imperative for optimizing outcomes and addressing the evolving landscape of paediatric liver disease management.<\/jats:p>","DOI":"10.3390\/children12040449","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T05:21:04Z","timestamp":1743398464000},"page":"449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Timing and Indications for Liver Transplantation for Children with Chronic Liver Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Risheka Lakshmi","family":"Suthantirakumar","sequence":"first","affiliation":[{"name":"Specialised Foundation Programme in Paediatrics, Imperial College London NHS Hospital Trust, London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-1583","authenticated-orcid":false,"given":"Girish L.","family":"Gupte","sequence":"additional","affiliation":[{"name":"Liver Unit (Including Small Bowel Transplantation), Birmingham Children\u2019s Hospital, Birmingham B4 6NH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.22271\/tpi.2019.v8.i2h.3053","article-title":"Prevention of chronic liver disease by applying therapeutic diet","volume":"8","author":"Tewari","year":"2019","journal-title":"Pharma Innov."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1053\/j.gastro.2018.05.032","article-title":"Increasing health care burden of chronic liver disease compared with other chronic diseases, 2004\u20132013","volume":"155","author":"Asrani","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0022-3476(87)80053-7","article-title":"Indications for pediatric liver transplantation","volume":"111","author":"Esquivel","year":"1987","journal-title":"J. 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