{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:06:38Z","timestamp":1760058398614,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Society for Pediatric Dermatology\/Pediatric Dermatology Research Alliance"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Vitiligo is an autoimmune condition causing melanocyte destruction and skin depigmentation. First-line treatments for vitiligo include topical medications and phototherapy; however, access and utilization of these treatments vary, particularly in pediatric patients. This study evaluates nbUVB use in pediatric versus adult vitiligo patients to better understand utilization in the pediatric population. Methods: A retrospective chart review study was conducted, collecting demographics and treatment characteristics for 102 adults and 19 children with vitiligo treated with nbUVB phototherapy at one institution. Statistical analysis included comparisons for categorical variables made using Chi-squared test or Fisher\u2019s exact test, as appropriate, and using a non-parametric Mann\u2013Whitney U test for continuous variables. Results: On average, adults underwent nbUVB for 23.8 months (range 0.5\u2013418, median 9), while children had an average duration of 14.8 months (range 2\u201360, median 8). The average number of nbUVB sessions for adults was 83.8, whereas children had an average of 33.5 sessions. Overall, 59.6% of adults and 60.0% of children experienced repigmentation with nbUVB. Conclusions: Retrospective analysis indicated that the duration and frequency of nbUVB sessions varied widely among both adults and children. While the average duration of treatment was comparable between the groups, children underwent fewer sessions on average. This may reflect differences in physician recommendation, scheduling constraints, or treatment adherence. Despite this variability, most pediatric patients exhibited repigmentation, supporting nbUVB efficacy. Our results suggest nbUVB is underutilized in pediatric vitiligo. Addressing obstacles to access is crucial for improving treatment outcomes and quality of life.<\/jats:p>","DOI":"10.3390\/children12040466","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:59:00Z","timestamp":1744091940000},"page":"466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Comparison of Narrowband-UVB Phototherapy in Pediatric Versus Adult Vitiligo"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-4156","authenticated-orcid":false,"given":"Kristin A.","family":"Tissera","sequence":"first","affiliation":[{"name":"School of Medicine, Duke University, Durham, NC 27710, USA"},{"name":"Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0862-3339","authenticated-orcid":false,"given":"Elena B.","family":"Hawryluk","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Department of Immunology, Dermatology Section, Boston Children\u2019s Hospital, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Cristina","family":"Garza-Mayers","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Seattle Children\u2019s Hospital, Seattle, WA 98105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.det.2019.08.005","article-title":"Phototherapy for Vitiligo","volume":"38","author":"Zubair","year":"2020","journal-title":"Dermatol. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1111\/jdv.19451","article-title":"Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: Towards a new management algorithm","volume":"37","author":"Speeckaert","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1111\/jdv.19450","article-title":"Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force\u2014Part 2: Specific treatment recommendations","volume":"37","author":"Seneschal","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_4","first-page":"CD003263","article-title":"Interventions for vitiligo","volume":"2","author":"Whitton","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/phpp.12277","article-title":"Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: A meta-analysis","volume":"33","author":"Li","year":"2017","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s13555-023-00983-3","article-title":"Real-World Treatment Patterns in Patients with Vitiligo in the United States","volume":"13","author":"Rosmarin","year":"2023","journal-title":"Dermatol. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaad.2023.02.010","article-title":"Narrowband ultraviolet B phototherapy in pediatric vitiligo: A retrospective study","volume":"89","author":"Paquette","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3889\/oamjms.2018.060","article-title":"Vitiligo in Children: What\u2019s New in Treatment?","volume":"6","author":"Gianfaldoni","year":"2018","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ad.2019.03.012","article-title":"Comparison of Phototherapy in Pediatric and Adult Patients. Experiencia en el uso de fototerapia en pacientes pedi\u00e1tricos y comparaci\u00f3n de esta t\u00e9cnica frente a pacientes adultos","volume":"111","year":"2020","journal-title":"Actas Dermo-Sifiliogr\u00e1ficas"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1001\/jamadermatol.2020.0218","article-title":"Evaluation for Skin Cancer and Precancer in Patients with Vitiligo Treated with Long-term Narrowband UV-B Phototherapy","volume":"156","author":"Bae","year":"2020","journal-title":"JAMA Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.36849\/JDD.7572","article-title":"The Pediatric Dermatologist\u2019s View of Pediatric Vitiligo","volume":"23","author":"Weingarten","year":"2024","journal-title":"J. Drugs Dermatol. JDD"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/pde.13098","article-title":"Efficacy and Safety of Targeted High-Intensity Medium-Band (304\u2013312 nm) Ultraviolet B Light in Pediatric Vitiligo","volume":"34","author":"Dong","year":"2017","journal-title":"Pediatr. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tissera, K.A., Hawryluk, E.B., Harris, J., and Garza-Mayers, A.C. (Pediatr. Dermatol., 2025). Survey of Access to and Use of Narrowband UVB Phototherapy in Pediatric Vitiligo, Pediatr. Dermatol., Epub ahead of print.","DOI":"10.1111\/pde.15937"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/cpt.3538","article-title":"Efficacy and Safety of Janus Kinase Inhibitors in Patients with Vitiligo: A Systematic Review and Meta-Analysis","volume":"117","author":"Huang","year":"2025","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/DSS.0000000000003860","article-title":"Updating the Fitzpatrick Classification: The Skin Color and Ethnicity Scale","volume":"49","author":"Coleman","year":"2023","journal-title":"Dermatol. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s40257-022-00752-6","article-title":"Vitiligo Treatments: Review of Current Therapeutic Modalities and JAK Inhibitors","volume":"24","author":"Cunningham","year":"2023","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1001\/jamadermatol.2024.0021","article-title":"Expert Recommendations on Use of Topical Therapeutics for Vitiligo in Pediatric, Adolescent, and Young Adult Patients","volume":"160","author":"Ezzedine","year":"2024","journal-title":"JAMA Dermatol."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/4\/466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:10:28Z","timestamp":1760029828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/4\/466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["children12040466"],"URL":"https:\/\/doi.org\/10.3390\/children12040466","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}