{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:27:13Z","timestamp":1783798033647,"version":"3.55.0"},"reference-count":52,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Hemophilia is an inherited bleeding disorder, with the most well-known forms being hemophilia A and hemophilia B. It is important for patients with hemophilia to maintain good oral health and prevent oral diseases because of their increased propensity to bleed. Few large-scale studies exist on the oral health status of patients with hemophilia. Methods: In our search across three databases (Web of Science, Scopus, and PubMed), only 14 articles about the oral health status of hemophilic patients were extracted. Oral health status was classified into caries status, periodontal status, and oral hygiene status and compared with that of a healthy group. Results: In total, 13 of the 14 papers investigated the dental caries status of hemophilia patients, and the most common report was \u201cno difference\u201d compared to healthy subjects (7 papers, 53.8%), followed by \u201cpoor\u201d (4 papers, 30.8%). Periodontal status was investigated in 6 papers, of which 4 (66.7%) reported that the status of hemophilia patients was \u201cpoor\u201d compared to that of healthy controls. Oral hygiene status was investigated in 12 studies, with 7 studies (58.3%) reporting it to be \u201cpoor\u201d in hemophilia patients compared to healthy controls, followed by 3 studies (25.0%) reporting \u201cno difference\u201d. Conclusions: Oral hygiene status is associated with other items, such as caries and periodontal disease, and it is paramount in maintaining good oral health in hemophilic patients. In addition, regular dental visits improve oral hygiene, resulting in the prevention of oral disease. It is important to increase awareness of this information among patients with hemophilia and for medical and dental professionals to cooperate to improve patients\u2019 oral health status, with the aim of improving their quality of life.<\/jats:p>","DOI":"10.3390\/children12040490","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:47:41Z","timestamp":1744282061000},"page":"490","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Systematic Review of the Oral Health Status of Hemophilic Patients"],"prefix":"10.3390","volume":"12","author":[{"given":"Tatsuya","family":"Akitomo","sequence":"first","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Kaneki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Mitsuhata","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0140-6736(03)13405-8","article-title":"Haemophilias A and B","volume":"361","author":"Pasi","year":"2003","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1182\/hematology.2022000388","article-title":"Gene therapy for hemophilia","volume":"2022","author":"Nathwani","year":"2022","journal-title":"Hematol. 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