{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:28:19Z","timestamp":1790879299908,"version":"4.1.0"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Anterior lip\/palate cleft is a congenital deformity affecting the upper lip and palate, posing significant challenges in both aesthetic and functional aspects for children. Effective management of this condition is crucial for improving quality of life and ensuring normal development. This review aims to highlight the regenerative treatment options available for children with anterior lip\/palate cleft, focusing on the use of bone grafts and other advanced dental procedures. A review of the current literature and clinical practices was conducted to identify and evaluate the most effective treatment options. Emphasis was placed on regenerative techniques, particularly the use of bone grafts. Advancements in regenerative dentistry offer promising outcomes for children with anterior lip\/palate cleft. Bone grafts, combined with innovative techniques such as growth factors, stem cell therapy, and distraction osteogenesis, provide effective solutions for restoring function and aesthetics. A multidisciplinary approach is essential to ensure comprehensive care and optimal results for these patients.<\/jats:p>","DOI":"10.3390\/children12050559","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T03:50:43Z","timestamp":1746071443000},"page":"559","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip\/Palate Cleft\u2014A Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Anna","family":"Miguel-Escribano","sequence":"first","affiliation":[{"name":"Department of Integrated Dentistry, School of Dentistry, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vall\u00e9s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9938-4187","authenticated-orcid":false,"given":"Cosimo","family":"Galletti","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery Kore, University of Enna, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"de Quixano-Bardaji","sequence":"additional","affiliation":[{"name":"Department of Integrated Dentistry, School of Dentistry, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vall\u00e9s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-5095","authenticated-orcid":false,"given":"Francisco","family":"Real-Voltas","sequence":"additional","affiliation":[{"name":"Department of Integrated Dentistry, School of Dentistry, Universitat Internacional de Catalunya, 08195 Sant Cugat del Vall\u00e9s, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-4165","authenticated-orcid":false,"given":"Luca","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Dental Cell Research, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pune 411018, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cuevas-Nunez","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Science and Morphological and Functional Imaging, University of Messina, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvia","family":"Galletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Science and Morphological and Functional Imaging, University of Messina, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1338-0551","authenticated-orcid":false,"given":"Javier","family":"Flores-Fraile","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jormas.2021.05.008","article-title":"Global prevalence of cleft palate, cleft lip and cleft palate and lip: A comprehensive systematic review and meta-analysis","volume":"123","author":"Salari","year":"2022","journal-title":"J. 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