{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:19:19Z","timestamp":1789503559014,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chongqing Municipal Education Commission","award":["KJQN202300428"],"award-info":[{"award-number":["KJQN202300428"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objectives: This study aimed to investigate changes in brain functional connectivity (FC) and topological structure in girls with idiopathic central precocious puberty (ICPP) using complex network theory analysis. Methods: Resting-state fMRI data from 53 ICPP girls (ages 6\u20138) and 51 controls were analysed. Graph theory was used to construct whole-brain functional networks, identify topological differences, and assess the relationship between sex hormone levels and network properties in regions with group differences. Results: RS-FC analysis revealed reduced connectivity in cognitive and emotional regulation regions in the ICPP group (p &lt; 0.05), but enhanced connectivity in emotional perception and self-regulation areas, such as the amygdala and insula (p &lt; 0.05), suggesting a compensatory mechanism. Graph theory showed that ICPP girls\u2019 brain networks maintained small-world properties (\u03b3 &gt; 1, \u03bb \u2248 1, \u03c3 &gt; 1). Local topological changes included decreased clustering and node efficiency in cognitive and emotional regulation regions, like the superior frontal gyrus and praecuneus (p &lt; 0.05), while emotional regulation regions (amygdala, insula) showed increased clustering and node efficiency (p &lt; 0.05), indicating compensation. Conclusions: This study highlights compensatory mechanisms in emotional regulation that may offset impairments in cognitive regions, offering new insights into ICPP\u2019s neural mechanisms.<\/jats:p>","DOI":"10.3390\/children12050565","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T03:50:43Z","timestamp":1746071443000},"page":"565","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered Brain Functional Connectivity and Topological Structural in Girls with Idiopathic Central Precocious Puberty: A Graph Theory Analysis Based on Resting-State fMRI"],"prefix":"10.3390","volume":"12","author":[{"given":"Lu","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7971-8936","authenticated-orcid":false,"given":"Jinhua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing 400014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1515\/jpem-2024-0419","article-title":"Development of a disease diagnostic model to predict the occurrence of central precocious puberty of female","volume":"38","author":"Zhao","year":"2025","journal-title":"J. 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