{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:14:18Z","timestamp":1760058858189,"version":"build-2065373602"},"reference-count":116,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Interest in the subject of umbilical cord clamping is long-standing. New evidence reveals that placental transfusion, facilitated by delayed cord clamping (DCC), reduces death and need for blood transfusions for preterm infants without evidence of harm. Even a brief delay in clamping the cord shows improved survival and well-being, but waiting at least two minutes is even better. We propose that three major benefits from DCC contribute to reduced mortality of preterm infants: (1) benefits from the components of blood; (2) assistance from the continued circulation of blood; and (3) the essential mechanical interactions that result from the enhanced volume of blood. The enhanced blood volume generates mechanical forces within the microcirculation that support the newborn\u2019s metabolic and cardiovascular stability and secure short- and long-term organ health. Several unique processes prime preterm and term newborns to receive the full placental transfusion, not to be misinterpreted as extra blood or over-transfusion. Disrupting cord circulation before the newborn\u2019s lung capillary bed has been fully recruited and the lungs can replace the placenta as a respiratory, gas-exchanging organ may be harmful. Early cord clamping also denies the newborn a full quota of iron-rich red blood cells as well as valuable stem cells for regeneration, repair, and seeding of a strong immune system. We propose that delayed cord clamping and intact-cord stabilization have the potential to save lives by protecting many neonates from hypovolemia, inflammation, and ischemia.<\/jats:p>","DOI":"10.3390\/children12050585","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:28:11Z","timestamp":1746174491000},"page":"585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How Delayed Cord Clamping Saves Newborn Lives"],"prefix":"10.3390","volume":"12","author":[{"given":"Judith","family":"Mercer","sequence":"first","affiliation":[{"name":"College of Nursing, University of Rhode Island, Kingston, RI 02881, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8335-7723","authenticated-orcid":false,"given":"Elisabeth","family":"Saether","sequence":"additional","affiliation":[{"name":"M\u00f8re and Romsdal Hospital Trust, 6026 \u00c5lesund, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-2506","authenticated-orcid":false,"given":"Tekoa","family":"King","sequence":"additional","affiliation":[{"name":"School of Nursing, University of California, San Francisco, CA 94143, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Maul","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology of the Asklepios Kliniken Barmbek, Wandsbek and Nord-Heidberg, 22039 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly Powell","family":"Kennedy","sequence":"additional","affiliation":[{"name":"School of Nursing, Yale University, West Haven, CT 06516, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-8607","authenticated-orcid":false,"given":"Debra","family":"Erickson-Owens","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Rhode Island, Kingston, RI 02881, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3972-0457","authenticated-orcid":false,"given":"Ola","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sk\u00e5ne University Hospital, 22185 Malmo\/Lund, Sweden"},{"name":"Department of Clinical Sciences, Pediatrics\/Neonatology, Lund University, 22362 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-8875","authenticated-orcid":false,"given":"Heike","family":"Rabe","sequence":"additional","affiliation":[{"name":"Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9QG, UK"},{"name":"Department of Neonatology, University Hospitals Sussex NHS Foundation Trust, Royal Sussex County Hospital, Brighton BN2 5BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","unstructured":"Darwin, E. 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