{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:06:42Z","timestamp":1776694002211,"version":"3.51.2"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Achondroplasia, the most common form of skeletal dysplasia, poses significant challenges for procedural sedation due to distinct anatomical and physiological features. This study evaluated the safety, effectiveness, and imaging quality of a standardized sedation protocol for magnetic resonance imaging (MRI) in children with achondroplasia. Methods: We conducted a single-center, retrospective analysis of 22 MRI procedures in 12 pediatric patients. Intravenous midazolam and propofol were used as primary sedatives, with continuous monitoring and standardized dosing. Sedation parameters were compared between children aged &lt;1 year and children aged \u22651 year. Results: The median sedation duration was 35 (25\u201365) min, and the median recovery time was 9 (5\u201314) min. No significant differences were found between age groups in midazolam dose (&lt;1 year: 0.15 \u00b1 0.05 mg\/kg vs. \u22651 year: 0.13 \u00b1 0.04 mg\/kg; p = 0.238), propofol induction (2.26 \u00b1 1.14 vs. 1.80 \u00b1 0.52 mg\/kg; p = 0.375), or infusion rate (3.18 \u00b1 2.74 vs. 5.13 \u00b1 2.65 mg\/kg\/h; p = 0.203), indicating protocol consistency. High-quality images were obtained in all cases. In one case (4.5%), self-limited desaturation to 92% occurred, with no intervention required. No airway instrumentation or other complications were reported. Conclusions: This protocol provides safe, effective, and reproducible sedation in children with achondroplasia, ensuring high-quality MRI with minimal adverse events.<\/jats:p>","DOI":"10.3390\/children12060662","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:49:57Z","timestamp":1747903797000},"page":"662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Single-Center Retrospective Analysis of a Standardized Sedation Protocol for MRI in Children with Achondroplasia: Minimal Complications and Excellent Imaging Quality"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-3662","authenticated-orcid":false,"given":"Barbora","family":"Nedomov\u00e1","sequence":"first","affiliation":[{"name":"Department of Pediatric Anesthesiology and Intensive Medicine, Faculty of Medicine, Comenius University and National Institute of Children\u2019s Diseases, 83340 Bratislava, Slovakia"},{"name":"Faculty of Medicine, Slovak Medical University, 83101 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Babulicov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology and Intensive Medicine, Faculty of Medicine, Comenius University and National Institute of Children\u2019s Diseases, 83340 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u013dubica","family":"Tich\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Comenius University and National Institute of Children\u2019s Diseases, 83340 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salome","family":"Jake\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Institute of Children\u2019s Diseases, 83340 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2229-0729","authenticated-orcid":false,"given":"Ladislava","family":"Ws\u00f3lov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, Informatics and BioStatistics, Faculty of Public Health, Slovak Medical University, 83101 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Riedel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology and Intensive Medicine, Faculty of Medicine, Comenius University and National Institute of Children\u2019s Diseases, 83340 Bratislava, Slovakia"},{"name":"Faculty of Medicine, Slovak Medical University, 83101 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"ref_1","unstructured":"(2025, April 01). 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