{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:19:06Z","timestamp":1760059146686,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Osteoporosis is the most common metabolic bone disorder, characterized by reduced bone mass and abnormal bone microarchitecture, resulting in increased bone fragility and a heightened risk of low-energy fractures. Pediatric osteoporosis may be either primary, due to genetic factors, or secondary, arising from chronic diseases and\/or their treatment. Oral health and proper occlusion are integral components of overall health, influencing functionality, nutrition, facial aesthetics, and psychosocial development during childhood. Severe malocclusion can adversely affect speech, mastication, appearance, psychological well-being, and social interactions. The aim of this narrative review is to examine the existing literature on orthodontic anomalies and management strategies in pediatric patients with osteoporosis while highlighting clinical challenges, treatment limitations, and areas necessitating further research. A comprehensive literature search was conducted in the PubMed database, focusing on studies involving human subjects aged 3 to 18 years, published in English between 2002 and 2024. The findings indicate that children with osteoporosis present with more severe dental and occlusal complications compared to their healthy peers, often facing increased orthodontic complexity due to skeletal fragility and systemic comorbidities. These challenges necessitate careful, individualized treatment planning and close multidisciplinary collaboration. Although research in this field remains limited due to the rarity of pediatric osteoporosis, recognizing and addressing the specific needs of this population is critical to improving clinical outcomes and guiding future therapeutic approaches.<\/jats:p>","DOI":"10.3390\/children12060691","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T03:30:19Z","timestamp":1748489419000},"page":"691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Orthodontics in Pediatric Osteoporosis: A Narrative Literature Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Anastasia Panagiota","family":"Gravia","sequence":"first","affiliation":[{"name":"Metabolic Bone Diseases, School of Medicine, National and Kapodistrian University of Athens, 14561 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heleni","family":"Vastardis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolos I.","family":"Tsolakis","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"Department of Orthodontics, Case Western Reserve University, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-6670","authenticated-orcid":false,"given":"Artemis","family":"Doulgeraki","sequence":"additional","affiliation":[{"name":"Department of Bone and Mineral Metabolism, Institute of Child Health, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R185","DOI":"10.1530\/EJE-14-0865","article-title":"Endocrinology and adolescence: Osteoporosis in children: Diagnosis and management","volume":"173","author":"Saraff","year":"2015","journal-title":"Eur. 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