{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:25:14Z","timestamp":1760059514386,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: To evaluate the effect of triptorelin on final height of girls with precocious or early puberty, compared to the untreated group, and to investigate factors that contribute to its maximum effectiveness in terms of final height. Methods: We collected for the last two decades the data of patients evaluated in our Pediatric Endocrinology Clinic for precocious (PP) (thelarche before 8 years of age) or early puberty (EP) (thelarche before 9 years of age) during the last two decades. Our final set included 178 girls (85 with precocious and 93 with early puberty, of whom 85 received triptorelin). Final heights, measured and documented by health professionals, and the exact date of menarche were collected after telephone communication. Logistic regression analysis assessed the effect of various parameters on the response to treatment. Results: \u03a4he difference in mean standard deviation (\u0394SDS) of final and midparental height did not show significant difference between treated and untreated girls (\u0394Height SDS (Final \u2212 Midparental): \u22120.20 \u00b1 0.89 vs. \u22120.28 \u00b1 0.83, p = 0.243). The results were similar when we compared the EP (\u22120.22 \u00b1 0.71 vs. \u22120.17 \u00b1 0.83, p = 0.778) and PP (\u22120.19 \u00b1 1.04 vs. \u22120.39 \u00b1 0.83, p = 0.315) subgroups. Menarche occurred earlier in the PP group compared to the EP group (10.68 \u00b1 1.22 vs. 11.12 \u00b1 0.90 years, p = 0.005) and in the untreated compared to the treated group (10.31 \u00b1 0.91 vs. 11.57 \u00b1 0.06 years, p &lt; 0.001 for EP, 11.53 \u00b1 0.90 vs. 9.86 \u00b1 0.86 years, p &lt; 0.001 for PP). Predictors of final height were height at diagnosis (positively correlated), midparental height, and bone age at diagnosis (negatively correlated). Conclusions: There was no significant difference in final height between treated and untreated girls. Triptorelin was effective in delaying the onset of menarche. Factors contributing to a better final height in treated girls were higher height at baseline, lower midparental height, and younger bone age.<\/jats:p>","DOI":"10.3390\/children12070818","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T10:43:15Z","timestamp":1750761795000},"page":"818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective Analysis on the Impact of Triptorelin on Final Height of Girls with Precocious and Early Puberty: A Single-Center, Long-Term Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4554-3116","authenticated-orcid":false,"given":"Georgia","family":"Sotiriou","sequence":"first","affiliation":[{"name":"Program of Postgraduate Studies \u201cAdolescent Medicine and Adolescent Health Care\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"First Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 54642 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5422-3988","authenticated-orcid":false,"given":"Anastasios","family":"Serbis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-3893","authenticated-orcid":false,"given":"Assimina","family":"Galli-Tsinopoulou","sequence":"additional","affiliation":[{"name":"Program of Postgraduate Studies \u201cAdolescent Medicine and Adolescent Health Care\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"Second Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA General Hospital, 54124 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4964-5726","authenticated-orcid":false,"given":"Athanasios","family":"Christoforidis","sequence":"additional","affiliation":[{"name":"First Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Hippokratio General Hospital, 54642 Thessaloniki, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S2213-8587(15)00418-0","article-title":"Pubertal development and regulation","volume":"4","author":"Abreu","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.14310\/horm.2002.1174","article-title":"Secular growth changes in the Hellenic population in the twentieth century","volume":"1","author":"Papadimitriou","year":"2002","journal-title":"Hormones"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S2213-8587(22)00339-4","article-title":"Molecular basis of normal and pathological puberty: From basic mechanisms to clinical implications","volume":"11","author":"Argente","year":"2023","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S2352-4642(23)00237-7","article-title":"Central precocious puberty: A review of diagnosis, treatment, and outcomes","volume":"7","author":"Zevin","year":"2023","journal-title":"Lancet Child Adolesc. 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