{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:27:50Z","timestamp":1760059670731,"version":"build-2065373602"},"reference-count":86,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Rett syndrome (RTT) is an X-linked neurodevelopmental disorder marked by neurological regression, autonomic dysfunction, seizures, and significant sleep and breathing abnormalities. About 80% of affected individuals, especially young children, experience sleep disturbances such as insomnia, sleep-disordered breathing, nocturnal vocalizations, bruxism, and seizures. Breathing irregularities during sleep\u2014like apnea, alternating hyperventilation, and hypoventilation\u2014are common, with both obstructive and central sleep apnea identified through polysomnography. This review focuses on the prevalent sleep disorders in children with Rett syndrome and highlights current recommendations for the management of sleep disorders.<\/jats:p>","DOI":"10.3390\/children12070869","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:46:12Z","timestamp":1751438772000},"page":"869","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sleep Disorders in Children with Rett Syndrome"],"prefix":"10.3390","volume":"12","author":[{"given":"Christopher","family":"Harner","sequence":"first","affiliation":[{"name":"College of Science, California State University, Turlock, CA 95382, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Gaffey","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Notre Dame, Notre Dame, IN 46556, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon S.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Medicine, Department of Pediatrics, School of Medicine Stanford, Stanford University, Lucile Packard Children\u2019s Hospital, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Witmans","sequence":"additional","affiliation":[{"name":"Division of Pulmonology, Department of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3349-8426","authenticated-orcid":false,"given":"Lourdes M.","family":"DelRosso","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Department of Internal Medicine, UCSF, Fresno, CA 93701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Anne","family":"Tablizo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pulmonology and Sleep Medicine, Department of Pediatrics, School of Medicine Stanford, Stanford University, Lucile Packard Children\u2019s Hospital, Stanford, CA 94305, USA"},{"name":"Division of Sleep Medicine, Department of Internal Medicine, UCSF, Fresno, CA 93701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","first-page":"723","article-title":"On a unusual brain atrophy syndrome in hyperammonemia in childhood","volume":"116","author":"Rett","year":"1966","journal-title":"Wien. 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