{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:29:09Z","timestamp":1760059749055,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Recurrent vomiting in infantile hypertrophic pyloric stenosis (IHPS) leads to metabolic alkalosis and a respiratory-driven compensatory hypercapnia. Alkalosis has been identified as the main causal factor for respiratory depression on admission. The value of contribution of hemoglobin and carbon dioxide partial pressure to this phenomenon will be evaluated. Materials and Methods: A retrospective cohort study was conducted on 105 infants with IHPS. The acid\/base status, including levels of hemoglobin and lactate, were recorded. Statistical comparisons, correlation analysis, linear regression and multivariate regression analysis were applied. Results: Hypercapnia was associated with hemoconcentration. We found a positive correlation was found between pCO2 and hemoglobin (p = 0.042). The multivariate linear regression analysis showed that pCO2 is dependent on hemoglobin (p = 0.002). Lactate, which is used as a marker for anaerobic glycolysis, showed no systematic correlation with pCO2. Conclusions: An increase in carbon dioxide cannot easily be attributed to a reduced transport function of carbon dioxide due to hemoglobin deficiency. Further investigation is needed to determine the extent to which low hemoglobin levels and increased pCO2 interact with hemoconcentration to contribute to respiratory problems.<\/jats:p>","DOI":"10.3390\/children12070885","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:19:27Z","timestamp":1751887167000},"page":"885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carbon Dioxide and Hemoglobin at Presentation with Hypertrophic Pyloric Stenosis\u2014Are They Relevant? Cohort Study and Current Opinions"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-5584","authenticated-orcid":false,"given":"Ralf-Bodo","family":"Tr\u00f6bs","sequence":"first","affiliation":[{"name":"Department of General-, Visceral- and Pediatric Surgery, St. Vinzenz Krankenhaus, 33098 Paderborn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiltrud","family":"Niggemann","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University Hospital Cologne, Kerpenerstr. 62, 50937 K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigore","family":"Cernaianu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, University Hospital Cologne, Kerpenerstr. 62, 50937 K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4428-4848","authenticated-orcid":false,"given":"Andreas","family":"Lipphaus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Ruhr-University of Bochum, St. Marie\u2019s Hospital Witten, Sankt Elisabeth Gruppe Herne, 58452 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-8127","authenticated-orcid":false,"given":"Matthias","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Ruhr-University of Bochum, St. Marie\u2019s Hospital Witten, Sankt Elisabeth Gruppe Herne, 58452 Witten, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1053\/j.sempedsurg.2016.05.004","article-title":"Contemporary management of pyloric stenosis","volume":"25","author":"Jobson","year":"2016","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00383-020-04810-0","article-title":"The incidence of infantile hypertrophic pyloric stenosis nearly halved from 2005 to 2017: Analysis of German administrative data","volume":"37","author":"Muensterer","year":"2021","journal-title":"Pediatr. Surg. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1542\/hpeds.2019-0112","article-title":"Pyloric stenosis: National trends in the incidence rate and resource use in the United States from 2012 to 2016","volume":"9","author":"Donda","year":"2019","journal-title":"Hosp. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1055\/s-0040-1721055","article-title":"The Dutch incidence of infantile hypertrophic pyloric stenosis and the influence of seasons","volume":"31","author":"Allema","year":"2021","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_5","first-page":"204","article-title":"Hypertrophic pyloric stenosis in the third world","volume":"41","author":"Saula","year":"2011","journal-title":"Trop. Dr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1440-1746.2010.06395.x","article-title":"Epidemiological features of infantile hypertrophic pyloric stenosis in Taiwan: A national study 1996\u20132004","volume":"26","author":"Tiao","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1440-1754.2000.00578.x","article-title":"Is acid base determination an accurate predictor of pyloric stenosis?","volume":"36","author":"Oakley","year":"2000","journal-title":"J. Paediatr. Child Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/0009922810384846","article-title":"The changing clinical presentation of hypertrophic pyloric stenosis: The experience of a large, tertiary care pediatric hospital","volume":"50","author":"Glatstein","year":"2011","journal-title":"Clin. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1016\/j.jpedsurg.2020.05.041","article-title":"Respiratory problems owing to severe metabolic alkalosis in infants presenting with hypertrophic pyloric stenosis","volume":"55","author":"Stevens","year":"2020","journal-title":"J. Pediatr. Surg."},{"key":"ref_10","unstructured":"Sur, M., and Hashmi, M.F. (2024, January 31). Alkalosis, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK545269\/."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.resp.2018.01.002","article-title":"The effect of metabolic alkalosis on the ventilatory response in healthy subjects","volume":"249","author":"Oppersma","year":"2018","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/pan.13879","article-title":"Perioperative apnea in infants with hypertrophic pyloric stenosis: A systematic review","volume":"30","author":"Stevens","year":"2020","journal-title":"Paediatr. Anaesth."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1055\/a-1984-9803","article-title":"Perioperative hypoxemia and postoperative respiratory events in infants with hypertrophic pyloric stenosis","volume":"33","author":"Stevens","year":"2023","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e000391","DOI":"10.1136\/wjps-2021-000391","article-title":"Postoperative apnea after pyloromyotomy for infantile hypertrophic pyloric stenosis","volume":"5","author":"Camporesi","year":"2022","journal-title":"World J. Pediatr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1515\/cclm-2018-1236","article-title":"Next-generation reference intervals for pediatric hematology","volume":"57","author":"Zierk","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.2215\/CJN.16041219","article-title":"Metabolic alkalosis: A brief pathophysiologic review","volume":"15","author":"Emmett","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/(SICI)1099-0496(199904)27:4<278::AID-PPUL9>3.0.CO;2-N","article-title":"Infants undergoing pyloromyotomy are not at risk for postoperative apnea","volume":"27","author":"Chipps","year":"1999","journal-title":"Pediatr. Pulmonol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/PEC.0b013e318209af50","article-title":"Alkalosis-induced respiratory depression from infantile hypertrophic pyloric stenosis","volume":"27","author":"Pappano","year":"2011","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.amj.2011.06.009","article-title":"Hypertrophic pyloric stenosis: It can take your breath away","volume":"31","author":"Tigges","year":"2012","journal-title":"Air Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/ajps.AJPS_51_16","article-title":"Infantile hypertrophic pyloric stenosis\u2014Our experience and challenges in a developing country","volume":"15","author":"Ezomike","year":"2018","journal-title":"Afr. J. Paediatr. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Ba\u0161kovi\u0107, M., and Sinjeri, D. (2022). Diagnostic accuracy of acid-base status in infants with hypertrophic pyloric stenosis. Children, 9.","DOI":"10.3390\/children9121815"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/bjs.1800790322","article-title":"Serum electrolytes and capillary blood gases in the management of hypertrophic pyloric stenosis","volume":"79","author":"Shanbhogue","year":"1992","journal-title":"Br. J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0735-6757(99)90009-8","article-title":"Diagnostic aids in the differentiation of pyloric stenosis from severe gastroesophageal reflux during early infancy: The utility of serum bicarbonate and serum chloride","volume":"17","author":"Smith","year":"1999","journal-title":"Am. J. Emerg. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/jpc.14372","article-title":"Presentation and outcomes in hypertrophic pyloric stenosis: An 11-year review","volume":"55","author":"Vinycomb","year":"2019","journal-title":"J. Paediatr. Child Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1152\/jappl.1997.83.1.240","article-title":"CO2 transport in normovolemic anemia: Complete compensation and stability of blood CO2 tensions","volume":"83","author":"Deem","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"ref_26","unstructured":"Barrett, K.E., Barman, S.M., Boitano, S.S., and Brooks, H. (2012). Ganong\u2019s Review of Medical Physiology, McGraw-Hill Medical. [24th ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Feng, Z., Nie, Y., Zhang, Y., Li, Q., Xia, H., Gong, S., Huang, H., and Huang, L.-M. (2014). The clinical features of infantile hypertrophic pyloric stenosis in Chinese Han Population: Analysis from 1998 to 2010. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088925"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/s41390-021-01473-y","article-title":"Carbon dioxide levels in neonates: What are safe parameters?","volume":"91","author":"Wong","year":"2022","journal-title":"Pediatr. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12245-017-0142-y","article-title":"Carbon dioxide poisoning: A literature review of an often forgotten cause of intoxication in the emergency department","volume":"10","author":"Permentier","year":"2017","journal-title":"Int. J. Emerg. Med."},{"key":"ref_30","unstructured":"Wikipedia Contributors (2024, October 08). Hypercapnia. Wikipedia, The Free Encyclopedia. Available online: https:\/\/en.wikipedia.org\/w\/index.php?title=Hypercapnia&oldid=1229466630."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMra1711860","article-title":"Diagnostic use of base excess in acid-base disorders","volume":"378","author":"Berend","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_32","first-page":"970","article-title":"Oxygen transport and delivery","volume":"Volume 1","author":"Polin","year":"2011","journal-title":"Fetal and Neonatal Physiology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1055\/s-0039-3401987","article-title":"A Delphi analysis to reach consensus on preoperative care in infants with hypertrophic pyloric stenosis","volume":"30","author":"Hall","year":"2020","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.jpedsurg.2019.01.059","article-title":"Association between anemia and postoperative complications in infants undergoing pyloromyotomy","volume":"54","author":"Kedir","year":"2019","journal-title":"J. Pediatr. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jss.2017.01.019","article-title":"Does metabolic alkalosis influence cerebral oxygenation in infantile hypertrophic pyloric stenosis?","volume":"212","author":"Nissen","year":"2017","journal-title":"J. Surg. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00000542-197512000-00013","article-title":"Lactate metabolism","volume":"43","author":"Cohen","year":"1975","journal-title":"Anesthesiology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1442-200X.2010.03185.x","article-title":"Infantile hypertrophic pyloric stenosis before 3 weeks of age in infants and preterm babies","volume":"53","author":"Huang","year":"2011","journal-title":"Pediatr. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/pr.2015.92","article-title":"Association of prematurity with the development of infantile hypertrophic pyloric stenosis","volume":"78","author":"Stark","year":"2015","journal-title":"Pediatr. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/0009922816641367","article-title":"Prematurity affects age of presentation of pyloric stenosis","volume":"56","author":"Costanzo","year":"2017","journal-title":"Clin. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jss.2021.12.042","article-title":"Open versus laparoscopic pyloromyotomy for pyloric stenosis. A systematic review and meta-analysis","volume":"274","author":"Lunger","year":"2022","journal-title":"J. Surg. Res."},{"key":"ref_42","first-page":"223","article-title":"Extramucous pyloromyotomy by laparoscopy","volume":"31","author":"Alain","year":"1990","journal-title":"Chir. Pediatr."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Tan, R.N.G.B., Pauws, S.C., van Loon, E., Smits, V.E.H.J., Lopriore, E., and Pas, A.B.T. (2018). Correlation and Interchangeability of Venous and Capillary Blood Gases in Non-Critically Ill Neonates. Front. Pediatr., 6.","DOI":"10.3389\/fped.2018.00089"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0954-6111(99)90264-0","article-title":"The effects of time delay and temperature on capillary blood gas measurements","volume":"93","author":"Dent","year":"1999","journal-title":"Respir. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13049-021-00848-8","article-title":"Is venous blood a more reliable description of acid-base state following simulated hypo- and hyperventilation?","volume":"29","author":"Shastri","year":"2021","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Xie, H., Lv, S., Chen, S., Pang, Z., Ye, D., Guo, J., Xu, W., and Jin, W. (2022). Agreement of potassium, sodium, glucose, and hemoglobin measured by blood gas analyzer with dry chemistry analyzer and complete blood count analyzer: A two-center retrospective analysis. Front. Med., 9.","DOI":"10.3389\/fmed.2022.799642"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Killilea, D.W., Kuypers, F.A., Larkin, S.K., and Schultz, K. (2022). Blood draw site and analytic device influence hemoglobin measurements. PLoS ONE, 17.","DOI":"10.1101\/2022.04.09.22273541"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/7\/885\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:04:32Z","timestamp":1760033072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/7\/885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["children12070885"],"URL":"https:\/\/doi.org\/10.3390\/children12070885","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2025,7,4]]}}}