{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:00:55Z","timestamp":1789408855268,"version":"build-2803163510"},"reference-count":26,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Although there is a critical need for timely, accurate recognition of infants with hypoxic ischemic encephalopathy (HIE) eligible for therapeutic hypothermia (TH), there is little published literature that comprehensively validates strategies to achieve this. For the Mater Mothers\u2019 Hospital, a screening protocol combining use of umbilical cord gases according to obstetric criteria and other evidence of depression at birth with a decision aid (the HIE Trigger Tool (TT)) for at-risk infants was developed. We audited whether the protocol supported appropriate clinical decisions. Methods: Obstetric records were searched from 1 January 2016 to 31 July 2022 for eligible infants. Neonatal records were examined to assess usage, determine outcomes (diagnosis of HIE or other neurological conditions, use of TH, mortality and neurodevelopmental outcomes) and detect any additional HIE cases. Results: Of 64,055 live births \u226535 weeks, 35.4% had cord gases taken. Of 580 eligible infants, the TT was applied to 498 (86.3%), 155 of whom screened positive for HIE (any severity). Of 76 infants with moderate or severe encephalopathy, 69 received TH. The other seven had contraindications to TH (n = 2), late presentations without any depression at birth (&gt;6 h, n = 3) or other causes of their encephalopathy (n = 2). The TT (which per instructions was commenced by one hour of age) was used to identify 61 of the infants with moderate\/severe encephalopathy, while 15 were diagnosed before it was applied. No infants who screened negative using the TT presented later with seizures or any other signs of moderate or severe HIE. Conclusions: The protocol including cord gases and the HIE TT is an effective method of screening for acute HIE needing TH.<\/jats:p>","DOI":"10.3390\/children12070892","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:19:27Z","timestamp":1751887167000},"page":"892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Strategy to Identify Infants with Hypoxic Ischemic Encephalopathy for Therapeutic Hypothermia\u2014A Retrospective Audit"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5906-861X","authenticated-orcid":false,"given":"Kristen","family":"Haakons","sequence":"first","affiliation":[{"name":"Mater Research, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD 4101, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-9849","authenticated-orcid":false,"given":"Kaycee","family":"Hocking","sequence":"additional","affiliation":[{"name":"Newborn Medicine, Mater Mothers\u2019 Hospital, South Brisbane, QLD 4101, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1448-8931","authenticated-orcid":false,"given":"Richard","family":"Mausling","sequence":"additional","affiliation":[{"name":"Newborn Medicine, Mater Mothers\u2019 Hospital, South Brisbane, QLD 4101, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8249-9516","authenticated-orcid":false,"given":"Helen G.","family":"Liley","sequence":"additional","affiliation":[{"name":"Mater Research, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, Brisbane, QLD 4101, Australia"},{"name":"Newborn Medicine, Mater Mothers\u2019 Hospital, South Brisbane, QLD 4101, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/jpc.13165","article-title":"Neonatal encephalopathy in New Zealand: Demographics and clinical outcome","volume":"52","author":"Battin","year":"2016","journal-title":"J. Paediatr. Child. Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","article-title":"Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome\u2014A systematic review","volume":"120","author":"Conway","year":"2018","journal-title":"Early Hum. Dev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study","volume":"33","author":"Sarnat","year":"1976","journal-title":"Arch. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1651-2227.1997.tb08581.x","article-title":"The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome","volume":"86","author":"Thompson","year":"1997","journal-title":"Acta Paediatr."},{"key":"ref_6","first-page":"Cd003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"2013","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Jia, W., Lei, X., Dong, W., and Li, Q. (2018). Benefits of starting hypothermia treatment within 6 h vs. 6-12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy. BMC Pediatr., 18.","DOI":"10.1186\/s12887-018-1013-2"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00431-021-04320-8","article-title":"New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy","volume":"181","author":"Victor","year":"2022","journal-title":"Eur. J. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"151904","DOI":"10.1053\/j.semperi.2024.151904","article-title":"Quality improvement and outcomes for neonates with hypoxic-ischemic encephalopathy: Obstetrics and neonatal perspectives","volume":"48","author":"Afifi","year":"2024","journal-title":"Semin. Perinatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"151930","DOI":"10.1016\/j.semperi.2024.151930","article-title":"How do we reach the goal of personalized medicine for neuroprotection in neonatal hypoxic-ischemic encephalopathy?","volume":"48","author":"Zhou","year":"2024","journal-title":"Semin. Perinatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/s41390-024-03184-6","article-title":"Regional variability in therapeutic hypothermia eligibility criteria for neonatal hypoxic-ischemic encephalopathy","volume":"96","author":"Proietti","year":"2024","journal-title":"Pediatr. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41390-024-03303-3","article-title":"Consensus definition and diagnostic criteria for neonatal encephalopathy-study protocol for a real-time modified delphi study","volume":"97","author":"Branagan","year":"2025","journal-title":"Pediatr. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00431-022-04666-7","article-title":"Healthcare organizational factors associated with delayed therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy: The LyTONEPAL cohort","volume":"182","author":"Beck","year":"2023","journal-title":"Eur. J. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bedetti, L., Lugli, L., Guidotti, I., Roversi, M.F., Muttini, E.D.C., Pugliese, M., Bertoncelli, N., Spaggiari, E., Todeschini, A., and Ancora, G. (2025). Real-World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors. Acta Paediatr.","DOI":"10.1111\/apa.70186"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/hpeds.2021-006135","article-title":"Standardized Evaluation of Cord Gases in Neonates at Risk for Hypoxic Ischemic Encephalopathy","volume":"12","author":"Blecharczyk","year":"2022","journal-title":"Hosp. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1515\/jpm-2020-0095","article-title":"Quality improvement for reducing utilization drift in hypoxic-ischemic encephalopathy management","volume":"49","author":"Carlton","year":"2021","journal-title":"J. Perinat. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2444448","DOI":"10.1001\/jamanetworkopen.2024.44448","article-title":"Perinatal Hypoxic-Ischemic Encephalopathy Among a Large Public Hospital Population","volume":"7","author":"Chalak","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e461","DOI":"10.1097\/pq9.0000000000000461","article-title":"Improving Compliance and Quality of Documentation of Cerebral Function Monitoring in a Neonatal Neurocritical Care Unit","volume":"6","author":"Goswami","year":"2021","journal-title":"Pediatr. Qual. Saf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/pch\/16.3.153","article-title":"Lessons learned during implementation of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy in a regional transport program in Ontario","volume":"16","author":"Khurshid","year":"2011","journal-title":"Paediatr. Child. Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1515\/jpm-2022-0421","article-title":"Quality improvement sustainability to decrease utilization drift for therapeutic hypothermia in the NICU","volume":"51","author":"Kieffer","year":"2023","journal-title":"J. Perinat. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e215","DOI":"10.1093\/pch\/pxaa075","article-title":"Impact of outreach education program on outcomes of neonates with hypoxic ischemic encephalopathy","volume":"26","author":"Mohammad","year":"2021","journal-title":"Paediatr. Child. Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/s41372-024-01916-4","article-title":"Standardizing neonatal hypoxic ischemic encephalopathy evaluation and documentation practices","volume":"44","author":"Peebles","year":"2024","journal-title":"J. Perinatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.resuscitation.2010.08.001","article-title":"Chain of Brain Preservation\u2014A concept to facilitate early identification and initiation of hypothermia to infants at high risk for brain injury","volume":"81","author":"Takenouchi","year":"2010","journal-title":"Resuscitation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e2023063032","DOI":"10.1542\/peds.2023-063032","article-title":"Trends in HIE and Use of Hypothermia in California: Opportunities for Improvement","volume":"154","author":"Bonifacio","year":"2024","journal-title":"Pediatrics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/archdischild-2020-319685","article-title":"Changing clinical characteristics of infants treated for hypoxic-ischaemic encephalopathy in England, Wales and Scotland: A population-based study using the National Neonatal Research Database","volume":"106","author":"Hage","year":"2021","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1056\/NEJMoa2119660","article-title":"Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns","volume":"387","author":"Wu","year":"2022","journal-title":"N. Engl. J. Med."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/7\/892\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:05:39Z","timestamp":1760033139000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/7\/892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["children12070892"],"URL":"https:\/\/doi.org\/10.3390\/children12070892","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]}}}