{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:31:00Z","timestamp":1760059860814,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Introduction: Fetal ovarian cysts are known to be a common form of fetal abdominal masses in female fetuses, often resulting from hormonal stimulation in utero. Although many resolve spontaneously without sequelae, others can develop into more complex pathologies, such as intracystic hemorrhage or torsion, which can compromise ovarian integrity and long-term reproductive outcomes. Early detection and appropriate follow-up evaluation are therefore crucial for optimal perinatal management. Materials and Methods: We conducted a retrospective study of 12 cases of fetal ovarian cysts diagnosed by routine prenatal ultrasound examinations over a two-year period at our institution. Inclusion criteria were the presence of a cystic adnexal lesion detected in utero, detailed prenatal ultrasound documentation, and a comprehensive postnatal examination. Sonographic features such as cyst size, internal echogenicity, and signs of vascular compromise were recorded. The mother\u2019s clinical variables, including gestational age at diagnosis and relevant medical conditions, were noted. Postnatal follow-up evaluation consisted of ultrasound examinations and, if indicated, pediatric surgical consultation. Results: Of the 12 cases, 9 were characterized by a simple cystic morphology. All spontaneously regressed postnatally and did not require surgical intervention. Three were defined as complex cysts showing septations or echogenic deposits; one of these cysts required immediate surgical exploration for suspected torsion. No cases with a malignant background were identified. All infants showed a favorable course with normal growth and development until follow-up evaluation. Conclusions: This series emphasizes that most fetal ovarian cysts are benign and often resolve without intervention, highlighting the benefit of systematic prenatal imaging. Nevertheless, complex or large cysts require close prenatal and neonatal monitoring to diagnose complications such as torsion.<\/jats:p>","DOI":"10.3390\/children12070934","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T13:00:51Z","timestamp":1752757251000},"page":"934","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Experience in the Management of a Series of Fetal\u2013Neonatal Ovarian Cysts"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-1756","authenticated-orcid":false,"given":"Constantin-Cristian","family":"V\u0103duva","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Filantropia Clinic Municipal Hospital, 200143 Craiova, Romania"},{"name":"Department of Obstetrics, Gynecology and IVF, HitMed Medical Center, 200130 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-0534","authenticated-orcid":false,"given":"Laurentiu","family":"Dira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Filantropia Clinic Municipal Hospital, 200143 Craiova, Romania"},{"name":"Department of Obstetrics, Gynecology and IVF, HitMed Medical Center, 200130 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7823-3387","authenticated-orcid":false,"given":"Dominic","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Medicine and Pharmacy, Clinic Emergency Hospital, 200642 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-3144","authenticated-orcid":false,"given":"Dan","family":"Ruican","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and IVF, HitMed Medical Center, 200130 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ani\u0219oara-Mirela","family":"Siminel","sequence":"additional","affiliation":[{"name":"Department of Neonatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Alin","family":"Stoica","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University of Medicine and Pharmacy, Emergency County Hospital, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1824-6354","authenticated-orcid":false,"given":"Mircea-Sebastian","family":"\u015eerb\u0103nescu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Medicine and Pharmacy, Filantropia Clinical Municipal Hospital Craiova, 200143 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Carp-Veli\u0219cu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and IVF, \u201cCarol Davila\u201d Bucharest Medical University, Prof. Dr \u201cPanait Sarbu\u201d Clinical Hospital, 060251 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"ref_1","first-page":"1757","article-title":"The Outcome of Simple Fetal Ovarian Cysts Diagnosed Antenatally","volume":"47","author":"Khalil","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104765","DOI":"10.1016\/j.amsu.2022.104765","article-title":"A Case of Huge Ovarian Cyst in Second Trimester: A Rare Case Report","volume":"82","author":"Acharya","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_3","unstructured":"Patru, C.L., Iliescu, D.G., Tanase, F., Dragusin, R.C., Sorop Florea, M., Capitanescu, R.G., Comanescu, A., Pana, R.C., Zorila, L.G., and Marinas, M.C. (2017, January 20\u201322). Fetal Heart in the First Trimester. The Added Value of the Outflow Tracts Evaluation. Proceedings of the Al V lea Congres de Ecografie in OG 2017, Targu Mures, Romania. Filodiritto Editore\u2014Proceedings."},{"key":"ref_4","first-page":"47","article-title":"Antenatal Natural History and Postnatal Outcomes of Fetal Ovarian Cysts","volume":"50","author":"Lee","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/pd.5143","article-title":"A Systematic Review and Meta-Analysis on Fetal Ovarian Cysts: Impact of Size, Appearance and Prenatal Aspiration","volume":"37","author":"Tyraskis","year":"2017","journal-title":"Prenat. Diagn."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Abbott, D.H., Padmanabhan, V., and Dumesic, D.A. (2006). Contributions of Androgen and Estrogen to Fetal Programming of Ovarian Dysfunction. Reprod. Biol. Endocrinol., 4.","DOI":"10.1186\/1477-7827-4-17"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1053\/j.sempedsurg.2005.01.002","article-title":"Ovarian Cysts in Infants and Children","volume":"14","author":"Brandt","year":"2005","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1016\/j.jpedsurg.2008.02.060","article-title":"Fetal ovarian cysts management and ovarian prognosis: A report of 82 cases","volume":"43","author":"Galinier","year":"2008","journal-title":"J. Pediatr. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Montaguti, E., Petrachi, B., Fiorentini, M., Arosio, V., Doroldi, S., Dionisi, C., Bernardi, V., and Pilu, G. (2024). The Role of Prenatal Ultrasound Examination in Predicting the Outcomes of Ovarian Fetal Cysts: A Pictorial Essay. Diagnostics, 14.","DOI":"10.3390\/diagnostics14232726"},{"key":"ref_10","first-page":"1069","article-title":"Results of in Vitro Fertilization after Diagnosis and Treatment of Chronic Endometritis","volume":"27","author":"Vaduva","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1053\/jpsu.2002.29421","article-title":"The Management of Fetal Ovarian Cysts","volume":"37","author":"Bagolan","year":"2002","journal-title":"J. Pediatr. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2003-37414","article-title":"Fetal Ovarian Cysts: Development and Neonatal Outcome","volume":"24","author":"Mittermayer","year":"2003","journal-title":"Ultraschall Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3346\/jkms.2006.21.4.690","article-title":"Clinical Experiences of Fetal Ovarian Cyst: Diagnosis and Consequence","volume":"21","author":"Kwak","year":"2006","journal-title":"J. Korean Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hara, T., Mimura, K., Endo, M., Fujii, M., Matsuyama, T., Yagi, K., Kawanishi, Y., Tomimatsu, T., and Kimura, T. (2021). Diagnosis, Management, and Therapy of Fetal Ovarian Cysts Detected by Prenatal Ultrasonography: A Report of 36 Cases and Literature Review. Diagnostics, 11.","DOI":"10.3390\/diagnostics11122224"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Melinte-Popescu, A.-S., Popa, R.-F., Harabor, V., Nechita, A., Harabor, A., Adam, A.-M., Vasilache, I.-A., Melinte-Popescu, M., Vaduva, C., and Socolov, D. (2023). Managing Fetal Ovarian Cysts: Clinical Experience with a Rare Disorder. Medicina, 59.","DOI":"10.3390\/medicina59040715"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/pd.5754","article-title":"Prenatal Evaluation and Postnatal Outcomes of Fetal Ovarian Cysts","volume":"40","author":"Chen","year":"2020","journal-title":"Prenat. Diagn."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000365146","article-title":"Postnatal Outcome in Cases of Prenatally Diagnosed Fetal Ovarian Cysts under Conservative Prenatal Management","volume":"37","author":"Nakamura","year":"2015","journal-title":"Fetal Diagn. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/uog.16002","article-title":"Outcome of Fetal Ovarian Cysts Diagnosed on Prenatal Ultrasound Examination: Systematic Review and Meta-Analysis","volume":"50","author":"Bascietto","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_19","first-page":"324","article-title":"[Fetal ovarian cysts\u2014420 cases from literature\u2014Metaanalysis 1984\u20132005]","volume":"78","year":"2007","journal-title":"Ginekol. Pol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bucuri, C., Mihu, D., Malutan, A., Oprea, V., Berceanu, C., Nati, I., Rada, M., Ormindean, C., Blaga, L., and Ciortea, R. (2023). Fetal Ovarian Cyst\u2014A Scoping Review of the Data from the Last 10 Years. Medicina, 59.","DOI":"10.3390\/medicina59020186"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Society for Maternal-Fetal Medicine (SMFM), and Cheng, Y. (2021). Ovarian Cysts. Am. J. Obstet. Gynecol., 225, B23\u2013B25.","DOI":"10.1016\/j.ajog.2021.06.042"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/uog.18973","article-title":"In-Utero Aspiration vs Expectant Management of Anechoic Fetal Ovarian Cysts: Open Randomized Controlled Trial","volume":"52","author":"Diguisto","year":"2018","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/crpm-2015-0020","article-title":"Management of Fetal Ovarian Cyst Using in Utero Aspiration","volume":"4","author":"Jwa","year":"2015","journal-title":"Case Rep. Perinat. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jpag.2014.10.003","article-title":"Ovarian Cyst Aspiration in the Neonate: Minimally Invasive Surgery","volume":"28","author":"Cho","year":"2015","journal-title":"J. Pediatr. Adolesc. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1148\/radiology.150.3.6695083","article-title":"Fetal Ovarian Cysts: Sonographic Detection and Association with Hypothyroidism","volume":"150","author":"Jafri","year":"1984","journal-title":"Radiology"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rotar, I.C., Tudorache, S., Staicu, A., Popa-Stanila, R., Constantin, R., Surcel, M., Zaharie, G.C., and Mure\u015fan, D. (2022). Fetal Ovarian Cysts: Prenatal Diagnosis Using Ultrasound and MRI, Management and Postnatal Outcome\u2014Our Centers Experience. Diagnostics, 12.","DOI":"10.3390\/diagnostics12010089"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"850","DOI":"10.7863\/jum.2003.22.8.850","article-title":"Diagnostic Imaging of Fetal Anomalies","volume":"22","author":"Bromley","year":"2003","journal-title":"J. Ultrasound Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1001\/archpedi.1974.02110300141022","article-title":"Bilateral Ovarian Cysts in the Newborn: A Triad of Neonatal Abdominal Masses, Polyhydramnios, and Maternal Diabetes Mellitus","volume":"128","author":"Bower","year":"1974","journal-title":"Am. J. Dis. Child."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/adc.50.1.45","article-title":"Follicular Ovarian Cysts in Stillbirths and Neonates","volume":"50","author":"deSa","year":"1975","journal-title":"Arch. Dis. Child."},{"key":"ref_30","unstructured":"Woodward, P. (2021). Diagnostic Imaging: Obstetrics, Elsevier. [4th ed.]."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/0002-9378(91)90532-V","article-title":"Fetal ovarian cysts: Prenatal ultrasonographic detection and postnatal evaluation and treatment","volume":"164","author":"Meizner","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/aogs.14584","article-title":"Fetal Abdominal Cysts: Predicting Adverse Outcomes","volume":"102","author":"Maiz","year":"2023","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_33","first-page":"43","article-title":"Daughter Cyst Sign","volume":"6","author":"Randazzo","year":"2012","journal-title":"J. Radiol. Case Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2214\/ajr.174.4.1741013","article-title":"\u201cDaughter Cyst\u201d Sign: A Sonographic Finding of Ovarian Cyst in Neonates, Infants, and Young Children","volume":"174","author":"Lee","year":"2000","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/pd.3921","article-title":"Fetal Ovarian Cysts: An Early Manifestation of McCune-Albright Syndrome?","volume":"32","author":"Gaspari","year":"2012","journal-title":"Prenat. Diagn."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1469-0705.2002.00725.x","article-title":"Fetal Ovarian Cysts: Prenatal Diagnosis, Management and Postnatal Outcome","volume":"20","author":"Heling","year":"2002","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.1469-0705.2001.00443.x","article-title":"Fetal Anemia as a Consequence of Hemorrhage into an Ovarian Cyst","volume":"17","author":"Abolmakarem","year":"2001","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-2007-999865","article-title":"Prenatal diagnosis of fetal abdominal masses by ultrasonography","volume":"3","author":"Brans","year":"1986","journal-title":"Am. J. Perinatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7863\/jum.1990.9.3.161","article-title":"Prenatal Sonographic Diagnosis and Subsequent Management of Fetal Adnexal Torsion","volume":"9","author":"Sherer","year":"1990","journal-title":"J. Ultrasound Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"523","DOI":"10.7863\/jum.2006.25.4.523","article-title":"Acute Progression of a Unilateral Fetal Ovarian Cyst to Complex Bilateral Cysts Causing Acute Polyhydramnios","volume":"25","author":"Bornstein","year":"2006","journal-title":"J. Ultrasound Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1159\/000086831","article-title":"Is Conservative Management of Prenatal and Neonatal Ovarian Cysts Justifiable?","volume":"20","author":"Foley","year":"2005","journal-title":"Fetal Diagn. Ther."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5152\/jtgga.2013.58855","article-title":"Prenatal Diagnosis of Fetal Ovarian Cyst: Case Report and Review of the Literature","volume":"14","author":"Erol","year":"2013","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1111\/jog.14768","article-title":"Case of Fetal Ovarian Juvenile Granulosa Cell Tumor: Complications and Management","volume":"47","author":"David","year":"2021","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/pbc.21775","article-title":"Neonatal Bilateral Ovarian Sex Cord Stromal Tumors","volume":"52","author":"Capito","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_45","first-page":"279","article-title":"Bilateral Ovarian Carcinoma in a 30 Week Fetus","volume":"40","author":"Ziegler","year":"1945","journal-title":"Arch. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dinu, M., Stancioi-Cismaru, A.F., Gheonea, M., Luciu, E.D., Aron, R.M., Pana, R.C., Marinas, C.M., Degeratu, S., Sorop-Florea, M., and Carp-Veliscu, A. (2023). Intrauterine Growth Restriction\u2014Prediction and Peripartum Data on Hospital Care. Medicina, 59.","DOI":"10.3390\/medicina59040773"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e1130","DOI":"10.1097\/SLA.0000000000005409","article-title":"Treatment and Outcomes of Congenital Ovarian Cysts A Study by the Canadian Consortium for Research in Pediatric Surgery (CanCORPS)","volume":"277","author":"Safa","year":"2023","journal-title":"Ann. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Han, L., Shi, G., Zheng, A., and Ruan, J. (2024). Laparoscopic Management of Neonatal Ovarian Torsion. J. Minim. Invasive Gynecol.","DOI":"10.1016\/j.jmig.2024.12.005"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/7\/934\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:10:23Z","timestamp":1760033423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/7\/934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["children12070934"],"URL":"https:\/\/doi.org\/10.3390\/children12070934","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2025,7,16]]}}}