{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:33:15Z","timestamp":1760059995897,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: Neonatal pain must be treated due to its potential short- and long-term adverse effects. A frenotomy is a painful procedure where common strategies to relieve pain (oral sucrose solutions and sucking) cannot be used because the technique is performed on the tongue. Lavender essential oil (LEO) is useful in treating pain during blood sampling, heel punctures, vaccination, and frenotomies. We aimed to determine whether smelling colostrum had similar effects as inhaled LEO during frenotomies. Methods: A prospective, randomized clinical trial was carried out with neonates who underwent a frenotomy for ankyloglossia between September 2023 and June 2024. We assessed pain using the NIPS score, heart rate, oxygen saturation, and crying time. After obtaining parental informed consent, we randomized patients into experimental and control groups. In both groups, we performed swaddling, administered 1 mL of oral sucrose, and let the newborn suck for 2 min. In the experimental group, we placed a gauze pad with two drops of colostrum, whereas in the control group, we used one drop of LEO 2 cm under the neonate\u2019s nose prior to and during the frenotomy. Results: We enrolled 142 patients (71 experimental cases and 71 controls). The experimental group showed lower crying times (28.0 vs. 40.2 s, p = 0.03). Both groups showed similar NIPS scores (1.4 vs. 1.5, p = 0.28). We observed no side effects in either of the groups. Conclusions: Inhaled colostrum and LEO help relieve pain in neonates who undergo a frenotomy for ankyloglossia and have no side effects. Aromatherapy with colostrum may decrease crying time during the frenotomy.<\/jats:p>","DOI":"10.3390\/children12080982","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T14:50:03Z","timestamp":1753714203000},"page":"982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Inhaled Colostrum as Effective as Inhaled Lavender Essential Oil for Pain Control in Neonatal Frenotomies? A Prospective, Randomized Clinical Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-611X","authenticated-orcid":false,"given":"Silvia","family":"Maya-Enero","sequence":"first","affiliation":[{"name":"Department of Neonatology, Service of Pediatrics, Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Passeig Mar\u00edtim 25-29, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-8302","authenticated-orcid":false,"given":"J\u00falia","family":"Candel-Pau","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Service of Pediatrics, Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Passeig Mar\u00edtim 25-29, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6285-383X","authenticated-orcid":false,"given":"Beatriz","family":"Valle-Del Barrio","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Service of Pediatrics, Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Passeig Mar\u00edtim 25-29, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"F\u00e0bregas-Mitjans","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Service of Pediatrics, Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Passeig Mar\u00edtim 25-29, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Prieto-Paja","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Service of Pediatrics, Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Passeig Mar\u00edtim 25-29, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-9405","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"L\u00f3pez-V\u00edlchez","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Service of Pediatrics, Hospital del Mar, Parc de Salut Mar, Universitat Pompeu Fabra, Passeig Mar\u00edtim 25-29, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,26]]},"reference":[{"key":"ref_1","first-page":"1684","article-title":"Protocolo para el manejo del dolor en Pediatr\u00eda [Protocol for the pain management in pediatrics]","volume":"31","year":"2009","journal-title":"Rev. Med. Electr\u00f3n."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jnn.2007.09.006","article-title":"The reality of neonatal pain and the resulting effects","volume":"13","author":"Urso","year":"2007","journal-title":"J. Neonatal Nurs."},{"key":"ref_3","unstructured":"Narbona L\u00f3pez, E., Contreras Chova, F., Garc\u00eda Iglesias, F., and Miras Baldo, M.J. (2024, November 11). Manejo del Dolor en el Reci\u00e9n Nacido [Newborn Pain Management]. Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda [Spanish Association of Pediatrics]. Available online: https:\/\/www.aeped.es\/sites\/default\/files\/documentos\/49.pdf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.pain.2010.10.008","article-title":"Pain in neonates is different","volume":"152","author":"Johnston","year":"2011","journal-title":"Pain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/01376517-200210000-00002","article-title":"Adverse effects of pain on the nervous systems of newborns and young children: A review of the literature","volume":"34","author":"Mitchell","year":"2002","journal-title":"J. Neurosci. Nurs."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2165\/11318900-000000000-00000","article-title":"Pain management in newborns: From prevention to treatment","volume":"12","author":"Annequin","year":"2010","journal-title":"Paediatr. Drugs"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1001\/jama.300.1.60","article-title":"Epidemiology and treatment of painful procedures in neonates in intensive care units","volume":"300","author":"Carbajal","year":"2008","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1001\/archpedi.157.11.1058","article-title":"Do we still hurt newborn babies? A prospective study of procedural pain and analgesia in neonates","volume":"157","author":"Simons","year":"2003","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mpaic.2008.02.007","article-title":"Acute pain management in the neonate","volume":"9","author":"Parry","year":"2006","journal-title":"Anaesth. Intensive Care Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0146-0005(98)80059-1","article-title":"Environmental and behavioral strategies to prevent and manage neonatal pain","volume":"22","author":"Franck","year":"1998","journal-title":"Semin. Perinatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102289","DOI":"10.1016\/j.ctim.2019.102289","article-title":"The effectiveness of familiar olfactory stimulation with lavender scent and glucose on the pain of blood sampling in term neonates: A randomized controlled clinical trial","volume":"49","author":"Razaghi","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Fitri, S.Y.R., Wardhani, V., Rakhmawati, W., Pahria, T., and Hendrawati, S. (2020). Culturally Based Practice in Neonatal Procedural Pain Management: A Mini Review. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.00540"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/ejp.824","article-title":"Combined non-pharmacological interventions for newborn pain relief in two degrees of pain procedures: A randomized clinical trial","volume":"20","author":"Leng","year":"2016","journal-title":"Eur. J. Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/dbp.0b013e31802d0b8d","article-title":"Familiarity breeds content? Soothing effect of a familiar odor on full-term newborns","volume":"28","author":"Goubet","year":"2007","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_15","first-page":"535","article-title":"The Effects of Lavender Scent on Pain of Blood Sampling in Term Neonates","volume":"3","author":"Razaghi","year":"2015","journal-title":"Int. J. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1542\/peds.74.6.1012","article-title":"Pacifying effects of nonnutritive sucking on term and preterm neonates during heelstick procedures","volume":"74","author":"Field","year":"1984","journal-title":"Pediatrics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/1166096","article-title":"A new look at some old mechanisms in human newborns: Taste and tactile determinants of state, affect, and action","volume":"59","author":"Blass","year":"1994","journal-title":"Monogr. Soc. Res. Child Dev."},{"key":"ref_18","first-page":"CD001069","article-title":"Sucrose for analgesia in newborn infants undergoing painful procedures","volume":"7","author":"Stevens","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1542\/peds.87.2.215","article-title":"Sucrose as an analgesic for newborn infants","volume":"87","author":"Blass","year":"1991","journal-title":"Pediatrics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1542\/peds.105.1.e14","article-title":"Skin-to-skin contact is analgesic in healthy newborns","volume":"105","author":"Gray","year":"2000","journal-title":"Pediatrics"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1001\/archpedi.157.11.1084","article-title":"Kangaroo care is effective in diminishing pain response in preterm neonates","volume":"157","author":"Johnston","year":"2003","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00044067-200507000-00010","article-title":"Skin-to-skin contact (Kangaroo Care) analgesia for preterm infant heel stick","volume":"16","author":"Hosseini","year":"2005","journal-title":"AACN Clin. Issues"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1542\/peds.109.4.590","article-title":"Breastfeeding is analgesic in healthy newborns","volume":"109","author":"Gray","year":"2002","journal-title":"Pediatrics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bmj.326.7379.13","article-title":"Analgesic effect of breast feeding in term neonates: Randomised controlled trial","volume":"326","author":"Carbajal","year":"2003","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1203\/00006450-200204000-00010","article-title":"Effect of multisensory stimulation on analgesia in term neonates: A randomized controlled trial","volume":"51","author":"Bellieni","year":"2002","journal-title":"Pediatr. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000047113","article-title":"Sensorial saturation: An effective analgesic tool for heel-prick in preterm infants: A prospective randomized trial","volume":"80","author":"Bellieni","year":"2001","journal-title":"Biol. Neonate"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Lewis, M., and Ramsay, D. (1999). A Two-Phase Model of the Soothing Taste Response: Implications for a Taste Probe of Temperament and Emotion Regulation, Soothing and Stress.","DOI":"10.4324\/9781410602626"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00004703-200112000-00006","article-title":"Effects of colostrum in newborn humans: Dissociation between analgesic and cardiac effects","volume":"22","author":"Blass","year":"2001","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s004310051011","article-title":"Comparison of sucrose and human milk on pain response in newborns","volume":"158","author":"Ors","year":"1999","journal-title":"Eur. J. Pediatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e20160955","DOI":"10.1542\/peds.2016-0955","article-title":"Sweet Solutions to Reduce Procedural Pain in Neonates: A Meta-analysis","volume":"139","author":"Harrison","year":"2017","journal-title":"Pediatrics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(10)61303-7","article-title":"Oral sucrose as an analgesic drug for procedural pain in newborn infants: A randomised controlled trial","volume":"376","author":"Slater","year":"2010","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s12519-022-00531-7","article-title":"Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates: A randomized clinical trial","volume":"18","year":"2022","journal-title":"World J. Pediatr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1007\/s00431-022-04608-3","article-title":"Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: A randomized clinical trial (NCT04867824)","volume":"181","year":"2022","journal-title":"Eur. J. Pediatr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/dev.10085","article-title":"Olfactory experience mediates response to pain in preterm newborns","volume":"42","author":"Goubet","year":"2003","journal-title":"Dev. Psychobiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00004703-200504000-00003","article-title":"The calming effect of a familiar odor on full-term newborns","volume":"26","author":"Rattaz","year":"2005","journal-title":"J. Dev. Behav. Pediatr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neures.2008.10.007","article-title":"The calming effect of a maternal breast milk odor on the human newborn infant","volume":"63","author":"Nishitani","year":"2009","journal-title":"Neurosci. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.clp.2019.08.006","article-title":"Nonpharmacologic Management of Pain During Common Needle Puncture Procedures in Infants: Current Research Evidence and Practical Considerations: An Update","volume":"46","author":"McNair","year":"2019","journal-title":"Clin. Perinatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1540-5834.1994.tb01285.x","article-title":"Hidden regulators in attachment, separation, and loss","volume":"59","author":"Hofer","year":"1994","journal-title":"Monogr. Soc. Res. Child Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/bfm.2015.0174","article-title":"Comparative Effect of the Smells of Amniotic Fluid, Breast Milk, and Lavender on Newborns\u2019 Pain During Heel Lance","volume":"11","author":"Akcan","year":"2016","journal-title":"Breastfeed. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/ANC.0000000000001190","article-title":"The Effect of Swaddling and Oropharyngeal Colostrum During Endotracheal Suctioning on Procedural Pain and Comfort in Premature Neonates: A Randomized Controlled Trial","volume":"24","author":"Karadede","year":"2024","journal-title":"Adv. Neonatal Care"},{"key":"ref_41","unstructured":"Hazelbaker, A.K. (1993). The Assessment Tool for Lingual Frenulum Function: Use in a Lactation Consultant Private Practice, Pacific Oaks College."},{"key":"ref_42","first-page":"59","article-title":"The development of a tool to assess neonatal pain","volume":"12","author":"Lawrence","year":"1993","journal-title":"Neonatal Netw."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"L\u00f3pez, V., Nielsen, B., Solas, M., Ram\u00edrez, M.J., and J\u00e4ger, A.K. (2017). Exploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System Targets. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00280"},{"key":"ref_44","first-page":"S194","article-title":"Non-pharmacological pain relief in labour","volume":"87","author":"Habanananda","year":"2004","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1054\/ctnm.1999.0901","article-title":"The use of aromatherapy in intrapartum midwifery practice an observational study","volume":"6","author":"Burns","year":"2000","journal-title":"Complement. Ther. Nurs. Midwifery"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1440-172X.2012.02015.x","article-title":"The effectiveness of aromatherapy massage using lavender oil as a treatment for infantile colic","volume":"18","year":"2012","journal-title":"Int. J. Nurs. Pract."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2648.2004.03172.x","article-title":"Aromatherapy practice in nursing: Literature review","volume":"48","author":"Wilkinson","year":"2004","journal-title":"J. Adv. Nurs."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1016\/j.pmn.2011.10.003","article-title":"The effect of a familiar scent on the behavioral and physiological pain responses in neonates","volume":"14","author":"Sadathosseini","year":"2013","journal-title":"Pain Manag. Nurs."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.pedneo.2013.04.004","article-title":"The calming effect of maternal breast milk odor on premature infants","volume":"54","author":"Badiee","year":"2013","journal-title":"Pediatr. Neonatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.pedneo.2015.09.004","article-title":"Effects of Breast Milk and Vanilla Odors on Premature Neonate\u2019s Heart Rate and Blood Oxygen Saturation During and After Venipuncture","volume":"57","author":"Neshat","year":"2016","journal-title":"Pediatr. Neonatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.15171\/jcs.2019.003","article-title":"The Effect of Aromatherapy by Lavender Oil on Infant Vaccination Pain: A Double Blind Randomized Controlled Trial","volume":"8","author":"Vaziri","year":"2019","journal-title":"J. Caring Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/j.1365-2702.2010.03356.x","article-title":"The effects of various interventions to newborns on pain and duration of crying","volume":"20","author":"Yilmaz","year":"2011","journal-title":"J. Clin. Nurs."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.earlhumdev.2007.10.008","article-title":"Lavender bath oil reduces stress and crying and enhances sleep in very young infants","volume":"84","author":"Field","year":"2008","journal-title":"Early Hum. Dev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1542\/peds.2004-0865","article-title":"Olfactory stimulation prevents apnea in premature newborns","volume":"115","author":"Marlier","year":"2005","journal-title":"Pediatrics"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/8\/982\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:16:28Z","timestamp":1760033788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/8\/982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,26]]},"references-count":54,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["children12080982"],"URL":"https:\/\/doi.org\/10.3390\/children12080982","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2025,7,26]]}}}