{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:08:49Z","timestamp":1787846929585,"version":"build-2784847793"},"reference-count":27,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Introduction: Obesity is a rapidly increasing condition that leads to serious health issues. The sense of smell, one of the oldest senses related to energy metabolism, has been increasingly studied in relation to obesity. Objective: This study investigates the impact of childhood obesity on the volumes of the olfactory bulb and pituitary gland, exploring the relationship between body mass index and these brain structures. Method: This study included 146 participants aged 6\u201318 years with different body mass indices between 2021 and 2024 at Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey. Participants were classified into normal weight, obese, and morbidly obese groups, and olfactory bulb and pituitary gland volumes were retrospectively analyzed. MRI scans were performed to exclude intracranial pathologies due to headache complaints, and patients with cranial pathologies were excluded from the study. Results: This study examined the olfactory bulb and pituitary gland volumes among normal weight, obese, and morbidly obese groups aged 6\u201318 years. In the morbidly obese group, right olfactory bulb area and right olfactory bulb volume were significantly higher compared to the other groups, while left olfactory bulb area was higher in both the obese and morbidly obese groups. Additionally, in the morbidly obese group, pituitary height was significantly lower than the other groups, and pituitary volume was also found to be reduced in morbid obesity. Conclusions: This study demonstrated that childhood obesity is linked to significant changes in the volumes of the olfactory bulb and pituitary gland. In morbidly obese children, an increase in pituitary volume and alterations in olfactory bulb volume suggest possible neuroanatomical adaptations.<\/jats:p>","DOI":"10.3390\/children12081009","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:37:47Z","timestamp":1754030267000},"page":"1009","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroanatomical Reflections of Childhood Obesity: Volumetric Analysis of the Pituitary Gland and Olfactory Bulb"],"prefix":"10.3390","volume":"12","author":[{"given":"Emel Hatun","family":"Ayta\u00e7 Kaplan","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, 34480 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4869-0309","authenticated-orcid":false,"given":"Elif","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Radiology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, 34480 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-2982","authenticated-orcid":false,"given":"Nazl\u0131 G\u00fcls\u00fcm","family":"Akyel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, 34480 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u00fcmr\u00fct","family":"Kocabey S\u00fct\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, 34480 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9082-6804","authenticated-orcid":false,"given":"\u015eeyda","family":"Do\u011fantan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, 34480 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3810\/pgm.2009.11.2074","article-title":"The medical risks of obesity","volume":"121","year":"2009","journal-title":"Postgrad. 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