{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:36:31Z","timestamp":1760060191799,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Children with juvenile idiopathic arthritis (JIA) may experience chronic pain, contributing to psychological distress. Objective: The objective was to assess neuropsychological functions and behavioral skills in patients with JIA and identify demographic and disease-related factors influencing these outcomes. Methods: This cross-sectional study evaluated 112 patients at the Division of Pediatric Rheumatology, Semmelweis University (2015\u20132016). Participants completed psychological assessments using the Child Behavior Checklist and Woodcock\u2013Johnson III Tests. Examined variables included demographic (age and sex), clinical (age at diagnosis and disease activity), and treatment-related factors (therapy type and duration). Treatment groups comprised (a) combination therapy with TNF inhibitor and methotrexate (MTX) (n = 60), (b) MTX monotherapy (n = 34), and (c) TNF inhibitor monotherapy (n = 18). Results: Neuropsychological variables showed no clinically significant differences between treatment groups. These skills were unaffected by age, sex, therapy duration, or disease activity. Pathological behavioral scores were significantly higher (p &lt; 0.05) in younger patients (&lt;7 years), with females showing greater susceptibility to anxiety and depression (p &lt; 0.05). Conclusions: No clinically significant psychological impairments were observed in our cohort. Further research is warranted to clarify the significance of abnormal behavioral scores. Psychological care provision remains vital for improving the quality of life in JIA patients.<\/jats:p>","DOI":"10.3390\/children12081057","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T07:53:44Z","timestamp":1754985224000},"page":"1057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Examination of Behavioral and Neuropsychological Characteristics of Hungarian Patients with Juvenile Idiopathic Arthritis: A Cross-Sectional Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Di\u00e1na","family":"Garan","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology and Immunology-Pediatric Center, Semmelweis University, T\u0171zolt\u00f3 Street 7-9, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Lengv\u00e1ri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology and Immunology-Pediatric Center, Semmelweis University, T\u0171zolt\u00f3 Street 7-9, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ponyi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology and Immunology-Pediatric Center, Semmelweis University, T\u0171zolt\u00f3 Street 7-9, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rton","family":"Szabados","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology and Immunology-Pediatric Center, Semmelweis University, T\u0171zolt\u00f3 Street 7-9, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyurgyinka","family":"Gergev","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology and Immunology-Pediatric Center, Semmelweis University, T\u0171zolt\u00f3 Street 7-9, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Bozi","sequence":"additional","affiliation":[{"name":"Auxiliis Pharma Budapest Kft., 1037 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"Wijker","sequence":"additional","affiliation":[{"name":"Auxiliis Pharma Budapest Kft., 1037 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Constantin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology and Immunology-Pediatric Center, Semmelweis University, T\u0171zolt\u00f3 Street 7-9, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/PHMT.S282611","article-title":"Physical Activity Interventions in Children with Juvenile Idiopathic Arthritis: A Systematic Review of Randomized Controlled Trials","volume":"13","author":"Iversen","year":"2022","journal-title":"Pediatr. 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