{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:37:15Z","timestamp":1790959035984,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objectives: To evaluate the clinical characteristics, complication rates, and predictors of adverse outcomes related to peripherally inserted central catheters (PICC) in newborns over a seven-year period in a tertiary neonatal intensive care unit (NICU). Materials and Methods: This retrospective observational study included all neonates who underwent their first PICC placement between January 2017 and January 2024 in a single tertiary NICU. Demographic, clinical, and procedural data were collected, including birth weight, gestational age, catheter type, insertion site, dwell time, and reason for removal. Primary outcomes were PICC-related complications and catheter dwell time. Statistical analyses included chi-square or Fisher\u2019s exact tests, Student\u2019s t-test or ANOVA, and multivariable logistic regression to identify independent predictors of complications. Results: A total of 610 PICCs were evaluated. The mean gestational age was 31.0 \u00b1 4.7 weeks, and the mean birth weight was 1579 \u00b1 870 g. The majority of catheters (96.1%) terminated at the central location, with a mean dwell time of 12.9 \u00b1 9.0 days. The most common removal reason was completion of therapy (60.3%), followed by mechanical complications (36.7%) and suspected infection (14.6%). Overall complication rate was 34.9%. In multivariable analysis, birth weight &gt; 1000 g was associated with a lower risk of complications compared to &lt;1000 g (1000\u20131500 g: OR 0.35, 95% CI 0.22\u20130.56; 1500\u20132000 g: OR 0.29, 0.15\u20130.54; &gt;2000 g: OR 0.44, 0.21\u20130.92). Midline (OR 4.16, 1.76\u20139.83) and peripheral (OR 3.51, 1.82\u20136.76) terminations carried higher risk compared to central terminations. Use of antimicrobial-impregnated catheters reduced complication risk (OR 0.44, 0.26\u20130.74), while temporal vein insertion increased it (OR 4.14, 1.23\u201313.86). Conclusions: Low birth weight (&lt;1000 g) and non-central catheter tip location are significant predictors of PICC-related complications in neonates, while antimicrobial-impregnated catheters have a protective effect. Targeted preventive strategies, strict adherence to insertion and maintenance bundles, and careful patient selection are recommended to improve outcomes in NICU patients.<\/jats:p>","DOI":"10.3390\/children12091168","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T09:24:41Z","timestamp":1756805081000},"page":"1168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Peripherally Inserted Central Catheters in Newborns: A Seven-Year Single-Center Experience from a Neonatal Intensive Care Unit"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0283-0457","authenticated-orcid":false,"given":"Hasan","family":"Avsar","sequence":"first","affiliation":[{"name":"Department of Neonatology, Gaziantep Liv Hospital, 27080 Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Bulbul","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Science, 34371 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evrim Kiray","family":"Bas","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Science, 34371 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Sinan","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Science, 34371 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru Turkoglu","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Sisli Hamidiye Etfal Education and Research Hospital, University of Health Science, 34371 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e34924","DOI":"10.1097\/MD.0000000000034924","article-title":"Risk factors for peripherally inserted central venous catheter-related complications in children: A retrospective cohort study","volume":"102","author":"Wang","year":"2023","journal-title":"Medicine"},{"key":"ref_2","first-page":"448","article-title":"Consensus document of the Spanish Society of Paediatric Infectious Diseases (SEIP) and the Spanish Society of Paediatric Intensive Care (SECIP) for the diagnosis and treatment of central venous catheter-related infections in paediatric care","volume":"100","author":"Grasa","year":"2024","journal-title":"An. 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