{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:03:32Z","timestamp":1792803812954,"version":"4.5.0"},"reference-count":19,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Salamanca (USAL)","id":[{"id":"https:\/\/ror.org\/02f40zc51","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: The primary aim of this study was to describe all cases of fetal hemivertebrae diagnosed prenatally at the Hospital Cl\u00ednico Universitario de Salamanca over the last 15 years. Additionally, the presence of associated malformations was assessed, pregnancy outcomes were evaluated, and child development results were analyzed in affected cases. Methods: We undertook a prospective observational analysis of all cases (N = 10) of prenatally diagnosed hemivertebrae at our hospital between 2007 and 2022. Postnatal follow-up was performed through telephone interviews and reviewing medical records. Results: Most cases were diagnosed during the second-trimester ultrasound, with the lumbar region being the most frequently affected site (60%). Multiple hemivertebrae were detected in 4 of 10 cases. One case of Marfan syndrome and two cases of VACTERL association (vertebral defects, anal atresia, tracheoesophageal fistula, renal dysplasia, and limb abnormalities) were documented. Six cases presented with additional malformations. Cases involving multiple hemivertebrae (40%) were more likely to be associated with other anomalies and poorer prognoses, while isolated single hemivertebra showed favorable outcomes, with normal development during childhood. Vaginal delivery occurred in six cases, while cesarean sections were performed for standard obstetric indications unrelated to the hemivertebra diagnosis. Conclusions: Prenatal diagnosis of hemivertebra is achievable and holds critical neonatal and postnatal relevance. Hemivertebrae are often linked to additional disorders, including genetic syndromes, and carry significant prognostic implications depending on the associated anomalies and the extent of vertebral involvement.<\/jats:p>","DOI":"10.3390\/children12091236","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T10:06:25Z","timestamp":1758017185000},"page":"1236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long-Term Outcomes of Prenatally Diagnosed Fetal Hemivertebra: A 15-Year Single-Center Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1544-9121","authenticated-orcid":false,"given":"Tatiana","family":"Costas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Faculty of Medicine, University of Salamanca (USAL), 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3425-9646","authenticated-orcid":false,"given":"Mar\u00eda de la O","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Faculty of Medicine, University of Salamanca (USAL), 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-2872","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mart\u00edn Esquilas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"Goenaga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Faculty of Medicine, University of Salamanca (USAL), 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Cabrero","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-4914","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Cubo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Faculty of Medicine, University of Salamanca (USAL), 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000082435","article-title":"Hemivertebra: Prenatal Diagnosis, Incidence and Characteristics","volume":"20","author":"Goldstein","year":"2005","journal-title":"Fetal Diagn. 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