{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:40:38Z","timestamp":1772149238752,"version":"3.50.1"},"reference-count":21,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:00:00Z","timestamp":1759622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: A variant of autism spectrum disorder (ASD) known as Asperger syndrome (AS) shows increasing incidence worldwide, affecting between 0.02% and 0.03% of children. Patients display abnormal conduct, are limited in social interaction and communication, and are more often affected by micturition disorders, incontinence, and voiding symptoms than typically developing children. Methods: The present study aimed to review the literature related to the current management of lower urinary tract conditions in children with Asperger syndrome and to present a case of a 14-year-old girl with ASD, with characteristic impairments, including communication challenges, stereotyped, repetitive behaviors, and chronic constipation with concomitant bladder dysfunction, presenting recurrent urinary tract infections (UTIs) and lower urinary tract symptoms (LUTS), including voiding and filling storage symptoms. For the AS, she was treated with a selective serotonin reuptake inhibitor (Sertraline). An abdominal ultrasound, PLUTTS\u2014pediatric lower urinary symptoms scoring (21); QL-quality of life (3); voiding diary; and uroflowmetry were performed, revealing an incomplete urinary retention (incomplete bladder emptying of 120 mL), a prolonged and interrupted curve, a maximum urinary flow rate (Qmax) 7 mL\/s, and a UTI with Enterococcus. Results: Besides psychiatric reevaluation and antibiotic therapy, functional magnetic stimulation (FMS) sessions were performed. After eight sessions (20 min, 35 MHz, every second day), the ultrasound control and the uroflowmetry showed no residual urine, and the Qmax was 17 mL\/s. The curve continued to be interrupted: PLUTSS-11, QL-1. FMS was continued at two sessions per week. At the 3-month follow-up, no residual urine was detected, and Qmax reached 24 mL\/s. Conclusions: ASD is an incapacitating\/debilitating condition that significantly impairs social functioning. In many cases, in addition to psychological symptoms, other conditions such as LUTS and constipation may coexist. Antipsychotics and antidepressants are frequently prescribed for these patients, often leading to various side effects, including micturition disorders. Therefore, screening for LUTS is recommended, and, if indicated, treatment\u2014especially non-pharmacological and non-invasive approaches, such as FMS\u2014should be considered.<\/jats:p>","DOI":"10.3390\/children12101340","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:10:51Z","timestamp":1759738251000},"page":"1340","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional Magnetic Stimulation in the Management of Lower Urinary Tract Dysfunction in Children with Asperger Syndrome: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Edva Anna","family":"Frunda","sequence":"first","affiliation":[{"name":"Institution Organizing University Doctoral Studies (I.O.S.U.D.), George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya Katalin Ilona","family":"M\u00e1rtha","sequence":"additional","affiliation":[{"name":"Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Urology, T\u00e2rgu Mure\u0219 Clinical Hospital, P-\u021ba Bern\u00e1dy Gy\u00f6rgy, Nr. 6, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\u2014Heim P\u00e1l, Semmelweis University, Baross utca 22, 1083 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rp\u00e1d Oliv\u00e9r","family":"Vida","sequence":"additional","affiliation":[{"name":"Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Urology, T\u00e2rgu Mure\u0219 Clinical Hospital, P-\u021ba Bern\u00e1dy Gy\u00f6rgy, Nr. 6, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8009-3482","authenticated-orcid":false,"given":"Tibor L\u00f3r\u00e1nd","family":"Reman","sequence":"additional","affiliation":[{"name":"Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Urology, T\u00e2rgu Mure\u0219 Clinical Hospital, P-\u021ba Bern\u00e1dy Gy\u00f6rgy, Nr. 6, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4778-380X","authenticated-orcid":false,"given":"Raul-Dumitru","family":"Gherasim","sequence":"additional","affiliation":[{"name":"Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Urology, T\u00e2rgu Mure\u0219 Clinical Hospital, P-\u021ba Bern\u00e1dy Gy\u00f6rgy, Nr. 6, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica Maria","family":"Ghirca","sequence":"additional","affiliation":[{"name":"Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Urology, T\u00e2rgu Mure\u0219 Clinical Hospital, P-\u021ba Bern\u00e1dy Gy\u00f6rgy, Nr. 6, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan C\u0103lin","family":"Chibelean","sequence":"additional","affiliation":[{"name":"Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Urology, T\u00e2rgu Mure\u0219 Clinical Hospital, P-\u021ba Bern\u00e1dy Gy\u00f6rgy, Nr. 6, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4279-673X","authenticated-orcid":false,"given":"Daniel","family":"Porav-Hodade","sequence":"additional","affiliation":[{"name":"Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Urology, T\u00e2rgu Mure\u0219 Clinical Hospital, P-\u021ba Bern\u00e1dy Gy\u00f6rgy, Nr. 6, 540072 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Viorica","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mure\u0219, Romania"},{"name":"Department of Pediatrics, County Emergency Hospital of T\u00e2rgu Mure\u0219, Str. Gh. Marinescu, Nr. 50, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pharmthera.2018.05.007","article-title":"Autism Spectrum Disorder: Classification, diagnosis and therapy","volume":"190","author":"Sharma","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Motlani, V., Motlani, G., and Thool, A. (2022). Asperger Syndrome (AS): A Review Article. Cureus, 14.","DOI":"10.7759\/cureus.31395"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1007\/s00787-017-1062-3","article-title":"Incontinence in autism spectrum disorder: A systematic review","volume":"27","author":"Niemczyk","year":"2018","journal-title":"Eur. Child. Adolesc. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/cap.2013.0111","article-title":"Micturition difficulty and urinary retention associated with aripiprazole and citalopram treatment in a male adolescent with Asperger syndrome","volume":"24","author":"Yalcin","year":"2014","journal-title":"J. Child. Adolesc. Psychopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"264.e1","DOI":"10.1016\/j.jpurol.2015.04.015","article-title":"Incontinence in children with autism spectrum disorder","volume":"11","author":"Pirrung","year":"2015","journal-title":"J. Pediatr. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s00787-022-02016-4","article-title":"Optimising the management of children with concomitant bladder dysfunction and behavioural disorders","volume":"32","author":"Eliezer","year":"2023","journal-title":"Eur. Child. Adolesc. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00431-020-03681-w","article-title":"EAU-ESPU guidelines recommendations for daytime lower urinary tract conditions in children","volume":"179","author":"Tekgul","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Raturi, S., Li, F.X., and Wong, C.M. (2021). Recognition and management of bladder bowel dysfunction in children with autism spectrum disorder. BMJ Case Rep., 14.","DOI":"10.1136\/bcr-2021-242646"},{"key":"ref_9","first-page":"475","article-title":"Urinary and bowel disfunction in autism spectrum disorder: A prospective, observational study","volume":"31","author":"Gubbiotti","year":"2019","journal-title":"Psychiatr. Danub."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2217\/npy.11.62","article-title":"Treatment of comorbid anxiety and autism spectrum disorders","volume":"1","author":"Nadeau","year":"2011","journal-title":"Neuropsychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/nau.21140","article-title":"Electrical stimulation for lower urinary tract dysfunction in children: A systematic review of the literature","volume":"30","author":"Hoebeke","year":"2011","journal-title":"Neurourol. Urodyn."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"332.e1","DOI":"10.1016\/j.jpurol.2019.03.025","article-title":"The overlooked association between lower urinary tract dysfunction and psychiatric disorders: A short screening test for clinical practice","volume":"15","author":"Mutluer","year":"2019","journal-title":"J. Pediatr. Urol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00467-017-3679-3","article-title":"Dysfunctional voiding: The importance of non-invasive urodynamics in diagnosis and treatment","volume":"33","author":"Clothier","year":"2018","journal-title":"Pediatr. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s12098-010-0170-6","article-title":"Non invasive urodynamic assessment in children\u2014Are they reliable? Validation of non-invasive urodynamics in children with functional voiding disorders","volume":"77","author":"Ramamurthy","year":"2010","journal-title":"Indian J. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2147\/CLEP.S230537","article-title":"Associations Between Psychiatric Disorders and Enuresis in Taiwanese Children: A National Population-Based Study","volume":"12","author":"Tsai","year":"2020","journal-title":"Clin. Epidemiol."},{"key":"ref_16","first-page":"30","article-title":"At-home transcutaneous electrical nerve stimulation: A therapeutic alternative in the management of pediatric overactive bladder syndrome","volume":"33","year":"2020","journal-title":"Cir Pediatr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1097\/01.ju.0000157336.87781.32","article-title":"Functional magnetic stimulation for mixed urinary incontinence","volume":"173","author":"But","year":"2005","journal-title":"J. Urol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/luts.12174","article-title":"High-power Magnetotherapy: A New Weapon in Urinary Incontinence?","volume":"10","author":"Palmieri","year":"2018","journal-title":"Low. Urin. Tract. Symptoms"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.5489\/cuaj.4411","article-title":"Bladder and bowel dysfunction in children: An update on the diagnosis and treatment of a common, but underdiagnosed pediatric problem","volume":"11","author":"Santos","year":"2017","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, C., Zhang, J., Zhang, H., Li, H., Yu, J., Pei, Y., and Fang, Y. (2024). Effects of different treatment frequencies of electromagnetic stimulation for urinary incontinence in women: Study protocol for a randomized controlled trial. Trials, 25.","DOI":"10.1186\/s13063-024-08103-y"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"322","DOI":"10.12965\/jer.1836222.111","article-title":"Urology as rehabilitation medicine: A literature review","volume":"14","author":"Kim","year":"2018","journal-title":"J. Exerc. Rehabil."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/10\/1340\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:27:19Z","timestamp":1760005639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/10\/1340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,5]]},"references-count":21,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["children12101340"],"URL":"https:\/\/doi.org\/10.3390\/children12101340","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,5]]}}}