{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:12:50Z","timestamp":1760037170297,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Snider Family and Snider Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objectives: Chronic pain corresponds to hypersensitivity to painful stimuli; however, its relation to acute pain sensitivity in children is poorly understood. We explored this relationship by comparing acute and chronic pain measures, along with related factors, in children with chronic pain syndromes versus controls, before and after therapeutic intervention. Methods: This prospective controlled cohort study involved 57 children with chronic pain undergoing intensive interdisciplinary pain treatment in a hospital-based pain rehabilitation program and 50 controls. Participants, aged 7\u201318, were tested using a cold pressor task (CPT) at admission, discharge, and first follow-up visit. Data on sleep, anxiety, psychological distress, functional impairment, and pain were collected. Results: Significant differences were found between control and treatment groups in average pain threshold (p &lt; 0.001), pain tolerance (p = 0.035), sleep visual analog scale (VAS) (p &lt; 0.001), functional disability inventory (p &lt; 0.001), patient reported outcomes information system anxiety assessment tool (p &lt; 0.001), general anxiety disorder 7-item scale (p &lt; 0.001), pain VAS (p &lt; 0.001) and total brief symptom inventory (BSI) (p &lt; 0.001) scores at admission with children with chronic pain scoring worse on all measures save the pain VAS during the CPT. After treatment and at follow-up, function and mental health measures improved but not acute pain threshold. Conclusions: At treatment completion, function and mental health significantly improved but acute pain threshold and sleep quality were unchanged. These findings suggest that while chronic pain treatment improves overall function and mental health, acute pain thresholds may not be a suitable indicator for evaluating the efficacy of interventions.<\/jats:p>","DOI":"10.3390\/children12101357","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:19:26Z","timestamp":1760015966000},"page":"1357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Pain in Children with Chronic Musculoskeletal Pain: A Prospective Controlled Study of Intensive Interdisciplinary Treatment"],"prefix":"10.3390","volume":"12","author":[{"given":"Rebecca","family":"Wells","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences,  University of California San Francisco, San Francisco, CA 94107, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6209-4733","authenticated-orcid":false,"given":"Mackenzie","family":"McGill","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA"},{"name":"Center for Pediatric Clinical Effectiveness, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19146, USA"},{"name":"PolicyLab, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19146, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Gmuca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA"},{"name":"Center for Pediatric Clinical Effectiveness, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19146, USA"},{"name":"PolicyLab, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19146, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashika","family":"Mani","sequence":"additional","affiliation":[{"name":"Biostatistics Analysis Center (BAC), University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Sherry","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Rheumatology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.pcl.2018.04.004","article-title":"Pediatric Pain Syndromes and Noninflammatory Musculoskeletal Pain","volume":"65","author":"Weiss","year":"2018","journal-title":"Pediatr. 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