{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:18:22Z","timestamp":1771474702918,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2023YFC2706503"],"award-info":[{"award-number":["2023YFC2706503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Beijing Natural Science Foundation","award":["J230009"],"award-info":[{"award-number":["J230009"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2022-2-2094"],"award-info":[{"award-number":["2022-2-2094"]}]},{"name":"Beijing Hospitals Authority\u2019s Ascent Plan","award":["DFL20221003"],"award-info":[{"award-number":["DFL20221003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objective: Crohn\u2019s disease exclusion diet (CDED) is used to induce remission and maintenance treatment of Crohn\u2019s disease (CD), but its efficacy as adjuvant treatment of biological agents is not clear, especially for children with CD in China. The aim is to compare the synergistic induction of remission, as well as the effects on physical growth and nutritional indicators, of the CDED and Exclusive Enteral Nutrition (EEN), when used alongside infliximab as adjunctive therapies for children with CD. Methods: A retrospective analysis was conducted on newly diagnosed children with CD who were receiving infliximab treatment in combination with either CDED or EEN at the Department of Gastroenterology at Beijing Children\u2019s Hospital between April 2022 and June 2025. The patients were divided into two groups: CDED and EEN. Changes in disease activity, physical growth indicators, nutritional status, and inflammatory markers were then compared between the two groups at six and twelve weeks post-treatment. Results: A total of 45 children with CD who met the inclusion and exclusion criteria were included in the study. Of these, 27 were boys (60%) and 18 were girls (40%), with an average age of (11.6 \u00b1 2.9) years. Based on nutritional intervention, 19 patients were assigned to the CDED group and 26 to the EEN group. The clinical remission rates were 89.5% and 94.7% at 6 and 12 weeks post-treatment, respectively, in the CDED group and 88.5% and 84.6%, respectively, in the EEN group. At 12 weeks, the endoscopic remission rates were 47.1% (8\/17) and 24.0% (5\/26), respectively, in the CDED and EEN groups. There were no statistically significant differences between the two groups in terms of clinical remission or endoscopic remission (p &gt; 0.05). Comparisons of physical growth indicators showed that, after 6 and 12 weeks of treatment, children in the CDED group had a significantly higher body mass index (BMI) for age Z-score than those in the EEN group (p &lt; 0.05). Comparisons of serum nutritional and inflammatory markers revealed that, after 12 weeks of treatment, fecal calprotectin levels were significantly lower in the CDED group than in the EEN group (p &lt; 0.05), with no significant differences observed in other markers. Conclusions: For children with moderate-to-severe or high-risk factors, CDED and EEN therapy as adjunctive treatment to infliximab demonstrate comparable efficacy in inducing disease remission. However, CDED was more effective than EEN at improving physical growth and reducing intestinal inflammation.<\/jats:p>","DOI":"10.3390\/children12111479","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:47:58Z","timestamp":1762177678000},"page":"1479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Modified Crohn\u2019s Disease Exclusion Diet as Adjunctive Therapy on Clinical Remission and Nutrition in Pediatric Crohn\u2019s Disease: A Real-World Study from China"],"prefix":"10.3390","volume":"12","author":[{"given":"Dongdan","family":"Li","sequence":"first","affiliation":[{"name":"Division of Clinical Nutrition, Beijing Pediatric Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Kong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Beijing Children\u2019s Medical Center, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Beijing Children\u2019s Medical Center, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Beijing Children\u2019s Medical Center, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feihong","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Beijing Children\u2019s Medical Center, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Beijing Children\u2019s Medical Center, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1053\/j.gastro.2021.12.282","article-title":"Twenty-first century trends in the global epidemiology of pediatric-onset inflammatory bowel disease: Systematic review","volume":"162","author":"Kuenzig","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.gtc.2021.12.013","article-title":"Pediatric Management of Crohn\u2019s Disease","volume":"51","author":"Mitchel","year":"2022","journal-title":"Gastroenterol. 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