{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:44:18Z","timestamp":1790477058852,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Exposure to potentially traumatic events (PTEs) during childhood and adolescence is relatively common and may result in the development of post-traumatic stress disorder (PTSD). Recent studies have demonstrated the utility of the network approach for examining PTSD symptoms. However, to date, no systematic review has focused exclusively on network-analytic evidence from child and adolescent samples, who require developmental specific evidence to inform clinical practice. Therefore, the present review aimed to summarize network-analytic studies investigating PTSD symptoms among trauma-exposed youth. Methods: Guided by the PRISMA guidelines, a systematic search for network-analytic studies exploring the symptom structure of PTSD-only in children and adolescents was conducted using PubMed and EBSCOHost. The methodological quality of included studies was assessed using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Results: Twelve studies (n = 12498; k = 18) were retrieved, with seven rated as of fair quality. Studies examined DSM-IV (n = 10) and DSM-5 (n = 2) PTSD symptoms in children and\/or adolescents exposed to PTEs (mostly natural disasters). Although central symptoms varied, heightened physiological reactivity consistently emerged among the most central. The strongest associations were observed between symptoms within the same PTSD cluster, and preliminary evidence suggests that network connectivity may increase with time since exposure. Conclusions: Heightened physiological reactivity to trauma-related cues appears to be a clinically relevant feature of youth exposed to PTEs, warranting consideration in assessment and intervention. Clinical and methodological implications and future directions for pediatric PTSD research are discussed.<\/jats:p>","DOI":"10.3390\/children12111516","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T08:57:55Z","timestamp":1762765075000},"page":"1516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Network Structure of PTSD Symptoms in Children and Adolescents Exposed to Potentially Traumatic Events: A Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Alberto","family":"Misitano","sequence":"first","affiliation":[{"name":"Trauma, Resilience, and Adjustment Investigation (TRAIL) Lab, Department of Psychology, Sigmund Freud University, 20143 Milan, Italy"},{"name":"Contextual Behavioral Science CBS-SFU Lab, Department of Psychology, Sigmund Freud University, 20143 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Trauma, Resilience, and Adjustment Investigation (TRAIL) Lab, Department of Psychology, Sigmund Freud University, 20143 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Febe","family":"Geddo","sequence":"additional","affiliation":[{"name":"Trauma, Resilience, and Adjustment Investigation (TRAIL) Lab, Department of Psychology, Sigmund Freud University, 20143 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Oppo","sequence":"additional","affiliation":[{"name":"Trauma, Resilience, and Adjustment Investigation (TRAIL) Lab, Department of Psychology, Sigmund Freud University, 20143 Milan, Italy"},{"name":"Contextual Behavioral Science CBS-SFU Lab, Department of Psychology, Sigmund Freud University, 20143 Milan, Italy"},{"name":"Istituto Europeo per lo Studio del Comportamento Umano (IESCUM), 43100 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-9729","authenticated-orcid":false,"given":"Barbara","family":"Forresi","sequence":"additional","affiliation":[{"name":"Trauma, Resilience, and Adjustment Investigation (TRAIL) Lab, Department of Psychology, Sigmund Freud University, 20143 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S2215-0366(19)30031-8","article-title":"The epidemiology of trauma and post-traumatic stress disorder in a representative cohort of young people in England and Wales","volume":"6","author":"Lewis","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2022). 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