{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:37:31Z","timestamp":1787027851663,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>A 9-year-old boy presented with edema of the left cheek. He was diagnosed with a large aneurysmal bone cyst of the mandibular bone. Off-label treatment with denosumab for 17 months resulted in a significant reduction in the lesion. Five months after discontinuing denosumab, the patient developed severe rebound hypercalcemia and acute kidney injury, which resolved with corticosteroids. Two years after treatment discontinuation, the lesion continues to decrease in size. This case highlights the efficacy of denosumab as an off-label treatment for aneurysmal bone cysts, though it can be associated with hypercalcemia and acute kidney injury. We conclude that the use of denosumab should be considered on a case-by-case basis, with regular monitoring for side effects.<\/jats:p>","DOI":"10.3390\/children12111524","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:57:41Z","timestamp":1762851461000},"page":"1524","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Significant Response to Denosumab Yet with Severe Rebound Hypercalcemia in a 9-Year-Old Boy with Aneurysmal Bone Cyst: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Laurence","family":"Allain","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayanthen","family":"Sathyakumar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1270-3701","authenticated-orcid":false,"given":"William","family":"Le Gallou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology, CHUL-Laval, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Coleman","sequence":"additional","affiliation":[{"name":"Montreal Children\u2019s Hospital, Montr\u00e9al, QC H4A 3H9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hallie","family":"Coltin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, CHU Sainte Justine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, QC H3C 3A7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8270-0417","authenticated-orcid":false,"given":"Dardye","family":"Eug\u00e8ne","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, CHUL-Laval, Quebec City, QC G1V 0A6, Canada"},{"name":"Department of Pediatrics, Laval University, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-5070","authenticated-orcid":false,"given":"Abha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1X6, Canada"},{"name":"Adolescent & Young Adult (AYA) Oncology Program, Princess Margaret Hospital, Toronto, ON M5G 1X6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-5462","authenticated-orcid":false,"given":"Sebastiano A. G.","family":"Lava","sequence":"additional","affiliation":[{"name":"Paediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 50, 1011 Lausanne, Switzerland"},{"name":"Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Renzi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada"},{"name":"Division of Pediatric Hematology Oncology, CHUL-Laval, Quebec City, QC G1V 0A6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1002\/1097-0142(19920615)69:12<2921::AID-CNCR2820691210>3.0.CO;2-E","article-title":"Aneurysmal bone cyst: A clinicopathologic study of 238 cases","volume":"69","author":"Bond","year":"1992","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.11604\/pamj.2013.15.111.2117","article-title":"Aneurysmal bone cyst primary: About eight pediatric cases: Radiological aspects and review of the literature","volume":"15","author":"Boubbou","year":"2013","journal-title":"Pan Afr. 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