{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:04:40Z","timestamp":1762916680008,"version":"3.45.0"},"reference-count":32,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background\/Objectives: This narrative review examines how developmentally appropriate safety and health education interventions in early childhood settings impact the incidence and severity of pediatric conditions requiring neurosurgical intervention, and which educational approaches most effectively promote neurological health and injury prevention among preschool-aged children. Methods: This narrative review employed a systematic literature search across medical and educational databases (ERIC, PsycINFO, MEDLINE, CINAHL, Education Source, and specialized neurosurgical sources) to identify relevant studies from 2000 to 2025. Results: Structured, play-based safety education in early childhood settings significantly reduces traumatic brain injury incidence. Programs integrating parent\u2013educator partnerships have shown greater effectiveness in establishing protective behaviors than classroom-only approaches. Culturally responsive interventions have demonstrated specific success in high-risk communities, reducing complications from untreated hydrocephalus resulting from infections. Early childhood education can significantly impact recognition of neurological warning signs. Conclusions: Early, developmentally appropriate health education establishes protective behaviors that reduce pediatric neurosurgical cases. Implementation should prioritize experiential safety learning, recognition of neurological warning signs, and strong family\u2013educator partnerships. Findings support integrating neurosurgical prevention strategies within early childhood curricula and developing interdisciplinary approaches connecting medical specialists with early childhood educators to reduce traumatic brain injuries, acquired hydrocephalus, and neural tube defects.<\/jats:p>","DOI":"10.3390\/children12111529","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T02:37:54Z","timestamp":1762915074000},"page":"1529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural Protection Through Health Education: Early Childhood Interventions to Prevent Neurological Conditions Requiring Surgical Care"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-1631","authenticated-orcid":false,"given":"Barnabas","family":"Obeng-Gyasi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Allegheny Health Network, Pittsburgh, PA 15212, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-3480","authenticated-orcid":false,"given":"Tyler M.","family":"Nolting","sequence":"additional","affiliation":[{"name":"Department of Health and Human Performance, Austin Peay State University, Clarksville, TN 37044, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3195-706X","authenticated-orcid":false,"given":"Emmanuel","family":"Obeng-Gyasi","sequence":"additional","affiliation":[{"name":"Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA"},{"name":"Environmental Health and Disease Laboratory, North Carolina A&T State University, Greensboro, NC 27411, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia S.","family":"Obeng","sequence":"additional","affiliation":[{"name":"Department of Applied Health Science, Indiana University School of Public Health\u2013Bloomington, Bloomington, IN 47405, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention Facts About TBI, Available online: https:\/\/www.cdc.gov\/traumatic-brain-injury\/data-research\/facts-stats\/index.html."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Vanderlind, W.M., Demers, L.A., Engelson, G., Fowler, R.C., and McCart, M. (2022). Back to school: Academic functioning and educational needs among youth with acquired brain injury. Children, 9.","DOI":"10.3390\/children9091321"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.pediatrneurol.2020.11.016","article-title":"Traumatic brain injury and school readiness among preschool-aged children in the United States","volume":"116","author":"Jackson","year":"2021","journal-title":"Pediatr. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41572-024-00519-9","article-title":"Paediatric hydrocephalus","volume":"10","author":"Kahle","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","first-page":"eaaz0846","article-title":"Paenibacillus infection with frequent viral coinfection contributes to postinfectious hydrocephalus in Ugandan infants","volume":"12","author":"Schiff","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhou, F., Yang, Z., Tang, Z., Zhang, Y., Wang, H., Sun, G., Zhang, R., Jiang, Y., Zhou, C., and Hou, X. (2023). Outcomes and prognostic factors of infantile acquired hydrocephalus: A single-center experience. BMC Pediatr., 23.","DOI":"10.1186\/s12887-023-04034-w"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e2494","DOI":"10.1002\/bdr2.2494","article-title":"Comparing folic acid interventions and arsenic reduction strategies for neural tube defect prevention in Bangladesh: A systematic review and decision analysis","volume":"117","author":"Wei","year":"2025","journal-title":"Birth Defects Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-nutr-043020-091647","article-title":"Folic acid and the prevention of birth defects: 30 years of opportunity and controversies","volume":"42","author":"Crider","year":"2022","journal-title":"Annu. Rev. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/09691413221102321","article-title":"Folic acid and neural tube defects: Discovery, debate and the need for policy change","volume":"29","author":"Wald","year":"2022","journal-title":"J. Med. Screen."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/bdr2.2115","article-title":"A 2022 global update on folic acid-preventable spina bifida and anencephaly","volume":"114","author":"Kancherla","year":"2022","journal-title":"Birth Defects Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3233\/NRE-2008-23604","article-title":"Return to school following childhood TBI: Who gets services?","volume":"23","author":"Glang","year":"2008","journal-title":"NeuroRehabilitation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1044\/leader.FTR1.17082012.10","article-title":"Schools as TBI service providers","volume":"17","year":"2012","journal-title":"ASHA Lead."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1017\/S1355617708081150","article-title":"Traumatic brain injury in young children: Post-acute effects on cognitive and school readiness skills","volume":"14","author":"Taylor","year":"2008","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_14","first-page":"3259","article-title":"Improving elementary students\u2019 knowledge and behavior to prevent traumatic injury: The impact of a behavioral skills training model delivered by aspirational role models","volume":"182","author":"Rodriguez","year":"2023","journal-title":"Eur. J. Pediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e00036224","DOI":"10.1590\/0102-311xen036224","article-title":"Educational strategies for preventing accidents in childhood: A systematic review","volume":"40","author":"Laguna","year":"2024","journal-title":"Cad. Saude Publica"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13756-025-01516-7","article-title":"Investigating the implementation of infection prevention and control practices in neonatal care across country income levels: A systematic review","volume":"14","author":"Nyantakyi","year":"2025","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1759","DOI":"10.1002\/hsr2.1759","article-title":"Addressing hydrocephalus in Africa: Challenges and way forward","volume":"6","author":"Kantawala","year":"2023","journal-title":"Health Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.whi.2023.08.006","article-title":"Hispanic women\u2019s perceptions of neural tube defects and folic acid supplementation: A qualitative study","volume":"34","author":"Riva","year":"2024","journal-title":"Women\u2019s Health Issues"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.acap.2020.12.002","article-title":"Pediatric primary care and partnerships across sectors to promote early child development","volume":"21","author":"Roby","year":"2021","journal-title":"Acad. Pediatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2105\/AJPH.2012.300687","article-title":"A new framework for childhood health promotion: The role of policies and programs in building capacity and foundations of early childhood health","volume":"102","author":"Mistry","year":"2012","journal-title":"Am. J. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s43058-025-00718-9","article-title":"Implementation strategies used in policy, systems, and environmental interventions addressing obesity-related outcomes in early childhood education settings: A systematic review","volume":"6","author":"Neshteruk","year":"2025","journal-title":"Implement. Sci. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2021052162","DOI":"10.1542\/peds.2021-052162","article-title":"Culturally sensitive interventions in pediatric primary care settings: A systematic review","volume":"149","author":"Okoniewski","year":"2022","journal-title":"Pediatrics"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ecresq.2023.03.006","article-title":"Promotion of early childhood development and mental health in quality rating and improvement systems for early care and education: A review of state quality indicators","volume":"64","author":"Hutchins","year":"2023","journal-title":"Early Child. Res. Q."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3233\/NRE-220218","article-title":"School-based interventions for children and adolescents following traumatic brain injury: A systematic review","volume":"52","author":"Clasby","year":"2023","journal-title":"NeuroRehabilitation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1016\/j.apmr.2022.01.011","article-title":"Traumatic brain injury education for children and adolescents with TBI, families and caregivers: A systematic scoping review","volume":"103","author":"Pappadis","year":"2022","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e1695","DOI":"10.1016\/S2214-109X(22)00461-2","article-title":"Postinfectious hydrocephalus in African infants: Common, under-recognised, devastating, and potential preventable","volume":"10","author":"Warf","year":"2022","journal-title":"Lancet Glob. Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"eaba0565","DOI":"10.1126\/scitranslmed.aba0565","article-title":"The bacterial and viral complexity of postinfectious hydrocephalus in Uganda","volume":"12","author":"Paulson","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_28","first-page":"173","article-title":"Prevention and treatment of neonatal infections in facility and community settings of low- and middle-income countries: A descriptive review","volume":"122","author":"Rehman","year":"2025","journal-title":"Neonatology"},{"key":"ref_29","first-page":"294","article-title":"Folate fortification and supplementation in prevention of folate-sensitive neural tube defects: A systematic review of policy","volume":"27","author":"Shlobin","year":"2020","journal-title":"J. Neurosurg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Belini Rodrigues, V., Nunes da Silva, E., and Pacheco Santos, M.L. (2021). Cost-effectiveness of mandatory folic acid fortification of flours in prevention of neural tube defects: A systematic review. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258488"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102366","DOI":"10.1016\/j.eclinm.2023.102366","article-title":"Global heterogeneity in folic acid fortification policies and implications for prevention of neural tube defects and stroke: A systematic review","volume":"67","author":"Quinn","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00381-023-05945-w","article-title":"The impact of voluntary folate fortification of corn masa flour on US pregnancies complicated by neural tube defects","volume":"39","author":"Khalid","year":"2023","journal-title":"Child\u2019s Nerv. 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