{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:42:34Z","timestamp":1764859354736,"version":"3.46.0"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Objective: To compare the efficacy of endoscopic retrograde cholangiopancreatography (ERCP) and the Frey procedure in the treatment of pediatric pancreatic duct stones (PDS). Methods: A retrospective analysis was conducted on 65 pediatric patients treated for pancreatic duct stones in the Department of Pediatric Surgery, West China Hospital of Sichuan University, between February 2018 and May 2025. Demographic data, perioperative clinical parameters, postoperative recovery, and complications were collected. The efficacy and complications of ERCP and the Frey procedure were evaluated. Results: Of the 65 patients, 37 (56.92%) were male and 28 (43.08%) were female, with a median surgical age of 14 (11, 16) years. 32 patients (49.23%) underwent ERCP, and 33 patients (50.77%) underwent the Frey procedure. Significant differences were observed between the two groups in the degree of main pancreatic duct dilation (6.45 vs. 9.11, p &lt; 0.001), postoperative stone recurrence (13 vs. 3, p = 0.003), and number of reinterventions (3.98 vs. 1.27, p &lt; 0.001). The 5-year intervention-free survival rate was 57.75% in the ERCP group and 88.86% in the Frey group, with a statistically significant difference between groups (p = 0.024). Conclusions: Both ERCP and the Frey procedure are effective for pediatric PDS. ERCP is preferred for patients with mild ductal dilation and first-onset stones. However, for those with significant ductal dilation or recurrent stones with suboptimal ERCP outcomes, the Frey procedure is recommended.<\/jats:p>","DOI":"10.3390\/children12111555","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:04:07Z","timestamp":1763388247000},"page":"1555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Endoscopic Retrograde Cholangiopancreatography and Frey Procedure in the Treatment of Pediatric Pancreatic Duct Stones: A Single-Center Retrospective Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3955-1036","authenticated-orcid":false,"given":"Zhenyu","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital, Sichuan University, #37 Guo-Xue-Xiang, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital, Sichuan University, #37 Guo-Xue-Xiang, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0482-971X","authenticated-orcid":false,"given":"Chengkun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital, Sichuan University, #37 Guo-Xue-Xiang, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital, Sichuan University, #37 Guo-Xue-Xiang, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5296-1873","authenticated-orcid":false,"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital, Sichuan University, #37 Guo-Xue-Xiang, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiulin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital, Sichuan University, #37 Guo-Xue-Xiang, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/den.12909","article-title":"Endoscopic treatment of pancreatic duct stones under direct vision: Revolution or resignation? Systematic review","volume":"30","author":"Beyna","year":"2018","journal-title":"Dig. Endosc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.3748\/wjg.v19.i37.6156","article-title":"Endotherapy in chronic pancreatitis","volume":"19","author":"Tandan","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/0016-5085(88)90178-3","article-title":"Evolution and regression of pancreatic calcification in chronic pancreatitis. A prospective long-term study of 107 patients","volume":"95","author":"Ammann","year":"1988","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1055\/s-2002-34256","article-title":"Endoscopic treatment of chronic pancreatitis: A multicenter study of 1000 patients with long-term follow-up","volume":"34","author":"Daniel","year":"2002","journal-title":"Endoscopy"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s12887-022-03207-3","article-title":"Utility of endoscopic retrograde cholangiopancreatography in management of pediatric pancreaticobiliary disease","volume":"22","author":"Makita","year":"2022","journal-title":"BMC Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1007\/s00383-022-05242-8","article-title":"Surgical drainage procedures for paediatric chronic pancreatitis: A scoping review","volume":"38","author":"Boam","year":"2022","journal-title":"Pediatr. Surg. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s11605-013-2167-8","article-title":"Hereditary pancreatitis: Endoscopic and surgical management","volume":"17","author":"Ceppa","year":"2013","journal-title":"J. Gastrointest. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1177\/2050640618817699","article-title":"Endoscopic treatment of chronic pancreatitis in pediatric population: Long-term efficacy and safety","volume":"7","author":"Kohoutova","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12873-019-0281-y","article-title":"Pancreatitis in pre-adolescent children: A 10\u2009year experience in the pediatric emergency department","volume":"19","author":"Randall","year":"2019","journal-title":"BMC Emerg. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.gie.2022.10.005","article-title":"American Society for Gastrointestinal Endoscopy guideline on post-ERCP pancreatitis prevention strategies: Summary and recommendations","volume":"97","author":"Buxbaum","year":"2023","journal-title":"Gastrointest. Endosc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.gie.2024.05.016","article-title":"American Society for Gastrointestinal Endoscopy guideline on the role of endoscopy in the management of chronic pancreatitis: Summary and recommendations","volume":"100","author":"Sheth","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1186\/s12887-023-04392-5","article-title":"Indications, success, and adverse event rates of pediatric endoscopic retrograde cholangiopancreatography (ERCP): A systematic review and meta-analysis","volume":"23","author":"Hosseini","year":"2023","journal-title":"BMC Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12887-017-0959-9","article-title":"Paediatric pancreaticobiliary endoscopy: A 21-year experience from a tertiary hepatobiliary centre and systematic literature review","volume":"18","author":"Keane","year":"2018","journal-title":"BMC Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jpedsurg.2017.01.051","article-title":"Success and safety of endoscopic retrograde cholangiopancreatography in children","volume":"52","author":"Rosen","year":"2017","journal-title":"J. Pediatr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/00006676-198711000-00014","article-title":"Description and rationale of a new operation for chronic pancreatitis","volume":"2","author":"Frey","year":"1987","journal-title":"Pancreas"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00383-020-04691-3","article-title":"Short- and long-term outcome of surgery for chronic pancreatitis in children: A single surgeon experience","volume":"36","author":"Ray","year":"2020","journal-title":"Pediatr. Surg. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"12644","DOI":"10.3748\/wjg.v21.i44.12644","article-title":"Single center experience in selecting the laparoscopic Frey procedure for chronic pancreatitis","volume":"21","author":"Tan","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/bjs\/znab473","article-title":"Short- and long-term outcomes of selective use of Frey or extended lateral pancreaticojejunostomy in chronic pancreatitis","volume":"109","author":"Kempeneers","year":"2022","journal-title":"Br. J. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00383-024-05784-z","article-title":"ERCP-Related adverse events in pediatric patients: A 10-years single-site review","volume":"40","author":"Li","year":"2024","journal-title":"Pediatr. Surg. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1046\/j.1440-1746.2001.02545.x","article-title":"Endoscopic retrograde cholangiopancreatography in the management of pancreaticobiliary disorders in children","volume":"16","author":"Poddar","year":"2001","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pan.2019.12.005","article-title":"International consensus guidelines for surgery and the timing of intervention in chronic pancreatitis","volume":"20","author":"Kempeneers","year":"2020","journal-title":"Pancreatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1055\/s-2008-1038497","article-title":"Diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in children and adolescents: Experience in a single institution","volume":"18","author":"Durakbasa","year":"2008","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.dld.2004.09.030","article-title":"Therapeutic ERCP in paediatric patients","volume":"37","author":"Rocca","year":"2005","journal-title":"Dig. Liver Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jpedsurg.2004.02.021","article-title":"Frey procedure for surgical management of chronic pancreatitis in children","volume":"39","author":"Rollins","year":"2004","journal-title":"J. Pediatr. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.jpedsurg.2015.07.012","article-title":"Frey procedure for chronic pancreatitis in children: A single center experience","volume":"50","author":"Ray","year":"2015","journal-title":"J. Pediatr. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.pan.2015.05.466","article-title":"Frey procedure for chronic pancreatitis: Evidence-based assessment of short- and long-term results in comparison to pancreatoduodenectomy and Beger procedure: A meta-analysis","volume":"15","author":"Zhou","year":"2015","journal-title":"Pancreatology"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Jeropoulos, R.M., Joshi, D., Aldeiri, B., and Davenport, M. (2024). Surgical and Endoscopic Intervention for Chronic Pancreatitis in Children: The Kings College Hospital Experience. Children, 11.","DOI":"10.3390\/children11010074"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/jamasurg.2013.3728","article-title":"The Frey procedure for chronic pancreatitis secondary to pancreas divisum","volume":"148","author":"Pappas","year":"2013","journal-title":"JAMA Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"104229","DOI":"10.1016\/j.amsu.2022.104229","article-title":"Frey procedure for chronic pancreatitis: A narrative review","volume":"80","author":"Ray","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4174\/astr.2020.98.4.190","article-title":"Drainage procedure for pancreatolithiasis: Re-examination of the pancreatic duct diameter standard","volume":"98","author":"Chen","year":"2020","journal-title":"Ann. Surg. Treat. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s00464-007-9334-5","article-title":"Pediatric ERCP in a multidisciplinary community setting: Experience with a fellowship-trained general surgeon","volume":"21","author":"Green","year":"2007","journal-title":"Surg. Endosc."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000319412","article-title":"Indications for endoscopic or surgical treatment of chronic pancreatitis","volume":"28","author":"Rieder","year":"2010","journal-title":"Dig. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/PL00009974","article-title":"Endoscopic retrograde cholangiopancreatography in infants and children","volume":"35","author":"Teng","year":"2000","journal-title":"J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.mpg.0000361657.54810.19","article-title":"Post-ERCP pancreatitis in pediatric patients","volume":"49","author":"Iqbal","year":"2009","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/MPG.0000000000003875","article-title":"Pediatric ERCP: Factors for Success and Complication-A 17-Year, Multisite Experience","volume":"77","author":"Lorio","year":"2023","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/jhbp.176","article-title":"Short- and long-term results of the Frey procedure for chronic pancreatitis","volume":"22","author":"Ueda","year":"2015","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.pan.2022.10.002","article-title":"Laparoscopic versus open Frey procedure: Comparative analysis of short and long-term outcomes","volume":"22","author":"Khatkov","year":"2022","journal-title":"Pancreatology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1491579","DOI":"10.3389\/fped.2025.1491579","article-title":"Pediatric endoscopic retrograde pancreatography expertise in chronic pancreatitis: A single-center analysis","volume":"13","author":"Guo","year":"2025","journal-title":"Front. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00595-017-1548-0","article-title":"Short- and long-term outcomes of the Frey procedure for chronic pancreatitis: A single-center experience and summary of outcomes in Japan","volume":"48","author":"Suzumura","year":"2018","journal-title":"Surg. Today"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/SLA.0b013e3181724ee7","article-title":"Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for surgical treatment of chronic pancreatitis: A systematic review and meta-analysis","volume":"247","author":"Diener","year":"2008","journal-title":"Ann. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1097\/SLA.0000000000002962","article-title":"Long-term Quality of Life and Gastrointestinal Functional Outcomes After Pancreaticoduodenectomy","volume":"268","author":"Allen","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1053\/j.gastro.2008.02.056","article-title":"Resection vs drainage in treatment of chronic pancreatitis: Long-term results of a randomized trial","volume":"134","author":"Strate","year":"2008","journal-title":"Gastroenterology"}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/11\/1555\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:31:23Z","timestamp":1764858683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/12\/11\/1555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["children12111555"],"URL":"https:\/\/doi.org\/10.3390\/children12111555","relation":{},"ISSN":["2227-9067"],"issn-type":[{"type":"electronic","value":"2227-9067"}],"subject":[],"published":{"date-parts":[[2025,11,17]]}}}