{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T23:01:27Z","timestamp":1768863687329,"version":"3.49.0"},"reference-count":19,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Mastocytosis is a rare hematologic disorder, classified into cutaneous mastocytosis (CM) and systemic mastocytosis (SM). Understanding age-related differences in presentation and management is essential for individualized care. Methods: Data from patients recruited from the Montreal Children\u2019s and Montreal General Hospitals between 2015 and 2024 were analyzed. Descriptive statistics were employed to present patient demographics, clinical characteristics, and medication usage. Statistical analyses included Fisher\u2019s exact test for categorical variables and t-tests or non-parametric equivalents for continuous variables. Results: A total of 63 patients were included, comprising 39 children and 24 adults. Children had a median age of 1.9 years, while adults had a median age of 49.3 years. CM was exclusively prevalent in children (100.0%), while SM was more common in adults (45.8%). Adults with SM had a significantly higher median age than CM (49.4 versus 44.7 years, respectively, p = 0.03). Epinephrine use was more frequent in adult SM patients (36.4% versus 0%, respectively, p = 0.03). No pediatric patients required epinephrine for symptom control. Conclusions: This study highlights important clinical differences between pediatric and adult mastocytosis. CM was more common in children while SM predominated in adults and was associated with greater flare severity and higher tryptase levels.<\/jats:p>","DOI":"10.3390\/children13010141","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:57:02Z","timestamp":1768816622000},"page":"141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Pediatric and Adult Mastocytosis: Clinical Presentation, Triggers, and Treatment Patterns from a Tertiary Care Registry"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6085-3408","authenticated-orcid":false,"given":"Sundus M.","family":"NoorSaeed","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia"},{"name":"Department of Pediatrics, Division of Allergy and Clinical Immunology and Dermatology, Montreal Children\u2019s Hospital, Montreal, QC H3H 1P3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, McGill University, Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athari","family":"Alenezi","sequence":"additional","affiliation":[{"name":"Division of Dermatology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-4644","authenticated-orcid":false,"given":"Eviatar","family":"Fields","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, McGill University, Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connor","family":"Prosty","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, McGill University, Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz S.","family":"Alrafiaah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Allergy and Clinical Immunology and Dermatology, Montreal Children\u2019s Hospital, Montreal, QC H3H 1P3, Canada"},{"name":"Department of Pediatrics, College of Medicine, Majmaah University, Majmaah 11952, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Miedzybrodzki","sequence":"additional","affiliation":[{"name":"Division of Dermatology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Netchiporouk","sequence":"additional","affiliation":[{"name":"Division of Dermatology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Sampalis","sequence":"additional","affiliation":[{"name":"Division of Surgical Research, Surgical Epidemiology, McGill University, Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Fein","sequence":"additional","affiliation":[{"name":"Division of Adult Allergy & Clinical Immunology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Ben-Shoshan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Allergy and Clinical Immunology and Dermatology, Montreal Children\u2019s Hospital, Montreal, QC H3H 1P3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1007\/s10238-023-01213-y","article-title":"Safety of COVID-19 mRNA vaccination and effects of SARS-CoV-2 infection in children and adults with mast cell disorders","volume":"23","author":"Zhu","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.rmed.2011.09.007","article-title":"The role of mast cells in allergic inflammation","volume":"106","author":"Amin","year":"2012","journal-title":"Respir. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1158\/0008-5472.CAN-16-2234","article-title":"Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future","volume":"77","author":"Valent","year":"2017","journal-title":"Cancer Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jaci.2021.04.013","article-title":"Prevalence of mastocytosis and Hymenoptera venom allergy in the United States","volume":"148","author":"Schuler","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2340\/1651-226X.2024.31406","article-title":"Epidemiology of mastocytosis: A population-based study (Sweden)","volume":"63","author":"Berglund","year":"2024","journal-title":"Acta Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10654-024-01195-5","article-title":"Prevalence and incidence of mastocytosis in adults: A Danish nationwide register study","volume":"40","author":"Jensen","year":"2025","journal-title":"Eur. J. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Brockow, K., Bent, R.K., Schneider, S., Spies, S., Kranen, K., Hindelang, B., Kurgyis, Z., Broesby-Olsen, S., Biedermann, T., and Grattan, C.E. (2024). Challenges in the Diagnosis of Cutaneous Mastocytosis. Diagnostics, 14.","DOI":"10.3390\/diagnostics14020161"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1182\/hematology.2022000366","article-title":"How to evaluate the patient with a suspected mast cell disorder and how\/when to manage symptoms","volume":"2022","author":"Akin","year":"2022","journal-title":"Hematology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1016\/j.jaip.2024.08.044","article-title":"Harmonization of Diagnostic Criteria in Mastocytosis for Use in Clinical Practice: WHO vs ICC vs AIM\/ECNM","volume":"12","author":"Valent","year":"2024","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Sandru, F., Petca, R.C., Costescu, M., Dumitra\u0219cu, M.C., Popa, A., Petca, A., and Miulescu, R.G. (2021). Cutaneous Mastocytosis in Childhood-Update from the Literature. J. Clin. Med., 10.","DOI":"10.3390\/jcm10071474"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18250","DOI":"10.18632\/oncotarget.4213","article-title":"Mastocytosis: A mutated KIT receptor induced myeloproliferative disorder","volume":"6","author":"Chatterjee","year":"2015","journal-title":"Oncotarget"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/leu.2015.24","article-title":"KIT mutation analysis in mast cell neoplasms: Recommendations of the European Competence Network on Mastocytosis","volume":"29","author":"Arock","year":"2015","journal-title":"Leukemia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2500\/aap.2019.40.4201","article-title":"Pediatric cutaneous mastocytosis and c-KIT mutation screening","volume":"40","author":"Ertugrul","year":"2019","journal-title":"Allergy Asthma Proc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.jaip.2020.12.019","article-title":"Criteria for the Regression of Pediatric Mastocytosis: A Long-Term Follow-Up","volume":"9","author":"Polivka","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/cea.12318","article-title":"Risk factors and management of severe life-threatening anaphylaxis in patients with clonal mast cell disorders","volume":"44","author":"Valent","year":"2014","journal-title":"Clin. Exp. Allergy J. Br. Soc. Allergy Clin. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1517\/14656566.2013.824424","article-title":"Mastocytosis: Update on pharmacotherapy and future directions","volume":"14","author":"Cardet","year":"2013","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"adv00583","DOI":"10.2340\/actadv.v101.350","article-title":"Role of Mast Cells in the Pathogenesis of Pruritus in Mastocytosis","volume":"101","author":"Kwiatkowska","year":"2021","journal-title":"Acta Derm. Venereol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.anai.2023.07.019","article-title":"Evidence-based use of antihistamines for treatment of allergic conditions","volume":"131","author":"Linton","year":"2023","journal-title":"Ann. Allergy Asthma Immunol. Off. Publ. Am. Coll. Allergy Asthma Immunol."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/1\/141\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T10:23:27Z","timestamp":1768818207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/1\/141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["children13010141"],"URL":"https:\/\/doi.org\/10.3390\/children13010141","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]}}}