{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T20:59:02Z","timestamp":1769461142546,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>Background: Elastic stable intramedullary nailing (ESIN) is widely used in pediatric trauma surgery for benefits such as early limb loading, short hospital stays, and easy implant removal. Perioperative antibiotic prophylaxis (PAP) is used to reduce surgical site infections (SSIs). However, the necessity of PAP in minimally invasive pediatric procedures like ESIN remains unclear. Methods: This retrospective analysis reviewed all pediatric fractures treated with ESIN osteosynthesis at a pediatric trauma center over a time span of 10 years. Focus was set on the use of PAP during implantation and complications in the period between osteosynthesis and implant removal, which was used as follow-up. Results: Between January 2013 and December 2023, a total of 979 ESIN osteosyntheses were performed. In total, 4.1% were lost to follow-up resulting in 939 eligible cases. Complications occurred in 14.7% of all cases. However, complications such as wound healing disorders, wound infections, and osteomyelitis were rare, at 1.7%. Between the different subgroups regarding the application of PAP, type of reduction, openness of the fractures, or localization, no significant differences were found. Conclusions: Besides the most minor complications, ESIN osteosynthesis in children and adolescents is safe treatment. No increased risk for complications was observed when closed reduction was performed without the administration of PAP.<\/jats:p>","DOI":"10.3390\/children13020168","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:24:36Z","timestamp":1769423076000},"page":"168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is Perioperative Antibiotic Prophylaxis Necessary for Pediatric and Adolescent ESIN Osteosyntheses?\u2014A Retrospective Analysis of 939 Surgical Procedures"],"prefix":"10.3390","volume":"13","author":[{"given":"Lino","family":"Hundhausen","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Orthopedics, Clinic St. Hedwig, Barmherzige Brueder Regensburg, KUNO Pediatric University Medical Center, Steinmetzstra\u00dfe 1-3, 93049 Regensburg, Germany"},{"name":"Department of Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wulbrand","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Orthopedics, Clinic St. Hedwig, Barmherzige Brueder Regensburg, KUNO Pediatric University Medical Center, Steinmetzstra\u00dfe 1-3, 93049 Regensburg, Germany"},{"name":"Department of Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, Germany"},{"name":"Department for Trauma, Orthopedics and Sports Medicine, Hospital Barmherzige Br\u00fcder Regensburg, Pr\u00fcfeninger Stra\u00dfe 86, 93049 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Scheerer-Harbauer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Orthopedics, Clinic St. Hedwig, Barmherzige Brueder Regensburg, KUNO Pediatric University Medical Center, Steinmetzstra\u00dfe 1-3, 93049 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Sperling","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Orthopedics, Clinic St. Hedwig, Barmherzige Brueder Regensburg, KUNO Pediatric University Medical Center, Steinmetzstra\u00dfe 1-3, 93049 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4109-1901","authenticated-orcid":false,"given":"Clemens","family":"Memmel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Orthopedics, Clinic St. Hedwig, Barmherzige Brueder Regensburg, KUNO Pediatric University Medical Center, Steinmetzstra\u00dfe 1-3, 93049 Regensburg, Germany"},{"name":"Department of Trauma Surgery, University Medical Center Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Hanke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Orthopedics, Clinic St. Hedwig, Barmherzige Brueder Regensburg, KUNO Pediatric University Medical Center, Steinmetzstra\u00dfe 1-3, 93049 Regensburg, Germany"},{"name":"Department for Trauma, Orthopedics and Sports Medicine, Hospital Barmherzige Br\u00fcder Regensburg, Pr\u00fcfeninger Stra\u00dfe 86, 93049 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF01763725","article-title":"Die Marknagelung von Knochenbr\u00fcchen","volume":"19","year":"1940","journal-title":"Klin. Wochenschr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF02600735","article-title":"Die Fixierung der trochanteren Br\u00fcche mit runden elastischen Condylenn\u00e4geln","volume":"2","author":"Ender","year":"1970","journal-title":"Acta Chir. Austriaca"},{"key":"ref_3","first-page":"209","article-title":"Elastic stable intramedullary pinning of long bone shaft fractures in children","volume":"40","author":"Ligier","year":"1985","journal-title":"Z. Kinderchir."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1302\/0301-620X.70B1.3339064","article-title":"Elastic stable intramedullary nailing of femoral shaft fractures in children","volume":"70","author":"Ligier","year":"1988","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.injury.2014.04.020","article-title":"Systematic review: Functional outcomes and complications of intramedullary nailing versus plate fixation for both-bone diaphyseal forearm fractures in children","volume":"45","author":"Patel","year":"2014","journal-title":"Injury"},{"key":"ref_6","first-page":"403","article-title":"The validity of ESIN method of osteosynthesis compared to other active surgical methods of treatment of diaphyseal fractures of long bones in children and adolescents","volume":"35","author":"Brekalo","year":"2011","journal-title":"Coll. Antropol."},{"key":"ref_7","unstructured":"European Centre for Disease Prevention and Control (2013). Systematic Review and Evidence-Based Guidance on Perioperative Antibiotic Prophylaxis, ECDC."},{"key":"ref_8","unstructured":"Deutsche Gesellschaft f\u00fcr Hygiene und Mikrobiologie e. V. (Hrsg.) (2025, June 29). S3-Leitlinie Perioperative und Periinterventionelle Antibiotikaprophylaxe\u2014Aktualisierung 2024. Langversion, 5.0. AWMF Registernummer: 067\/009. Available online: https:\/\/register.awmf.org\/de\/leitlinien\/detail\/067-009."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2146\/ajhp120568","article-title":"Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"70","author":"Bratzler","year":"2013","journal-title":"Am. J. Health Syst. Pharm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/jpc.14484","article-title":"Adherence to surgical antibiotic prophylaxis guidelines in children: A cohort study","volume":"56","author":"Palasanthiran","year":"2020","journal-title":"J. Paediatr. Child. Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1055\/s-0043-1778020","article-title":"Moving toward the Development and Effective Implementation of High-Quality Guidelines in Pediatric Surgery: A Review of the Literature","volume":"34","author":"Irvine","year":"2024","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00383-014-3623-6","article-title":"The quality of guidelines in pediatric surgery: Can we all AGREE?","volume":"31","author":"Shawyer","year":"2015","journal-title":"Pediatr. Surg. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/sur.2022.131","article-title":"Surgical Antibiotic Prophylaxis in Children Undergoing Surgery: A Systematic Review and Meta-Analysis","volume":"23","author":"Nthumba","year":"2022","journal-title":"Surg. Infect."},{"key":"ref_14","first-page":"233","article-title":"Perioperative Antibiotic Prophylaxis\u2014Indications and Modalities for the Prevention of Postoperative Wound Infection","volume":"121","author":"Eckmann","year":"2024","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S135","DOI":"10.1097\/00005131-200711101-00020","article-title":"Fracture and dislocation classification compendium for children: The AO pediatric comprehensive classification of long bone fractures (PCCF)","volume":"21","author":"Slongo","year":"2007","journal-title":"J. Orthop. Trauma"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2106\/00004623-197658040-00004","article-title":"Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: Retrospective and prospective analyses","volume":"58","author":"Gustilo","year":"1976","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11832-010-0245-y","article-title":"Failures and complications in intramedullary nailing of children\u2019s forearm fractures","volume":"4","author":"Fernandez","year":"2010","journal-title":"J. Child. Orthop."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/os.12977","article-title":"Clinical Efficacy of Minimally Invasive Elastic Stable Intramedullary Nailing for Limb Long Bone Fractures in Children","volume":"13","author":"Dong","year":"2021","journal-title":"Orthop. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00264-016-3259-3","article-title":"Complications of elastic stable intramedullary nailing of femoral shaft fractures in children weighing fifty kilograms (one hundred and ten pounds) and more","volume":"40","author":"Canavese","year":"2016","journal-title":"Int. Orthop."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-2008-1072383","article-title":"Elastic stable intramedullary nailing (ESIN) provides good long-term results in pediatric long-bone fractures","volume":"10","author":"Till","year":"2000","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jor.2020.01.002","article-title":"Flexible intramedullary nailing in the treatment of forearm fractures in children and adolescents, a systematic review","volume":"20","author":"Poutoglidou","year":"2020","journal-title":"J. Orthop."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jor.2013.01.003","article-title":"Complications of Elastic Stable Intramedullary Nailing for treating paediatric long bone fractures","volume":"10","author":"Nisar","year":"2013","journal-title":"J. Orthop."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/BPO.0b013e318165210d","article-title":"Elastic stable intramedullary nailing of tibial shaft fractures in children","volume":"28","author":"Srivastava","year":"2008","journal-title":"J. Pediatr. Orthop."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e6669","DOI":"10.1097\/MD.0000000000006669","article-title":"Low complication rate of elastic stable intramedullary nailing (ESIN) of pediatric forearm fractures: A retrospective study of 202 cases","volume":"96","author":"Kruppa","year":"2017","journal-title":"Medicine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1097\/BPO.0000000000002374","article-title":"Subsequent Forearm Fractures Following Initial Surgical Fixation","volume":"43","author":"Lindgren","year":"2023","journal-title":"J. Pediatr. Orthop."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2309499020972204","DOI":"10.1177\/2309499020972204","article-title":"Plate fixation versus titanium elastic nailing in midshaft clavicle fractures based on fracture classifications","volume":"28","author":"Park","year":"2020","journal-title":"J. Orthop. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/BPO.0b013e31829d1a76","article-title":"Elastic stable intramedullary nailing for displaced pediatric clavicle midshaft fractures: A prospective study of the results and patient satisfaction in 24 children and adolescents aged 10 to 15 years","volume":"33","author":"Rapp","year":"2013","journal-title":"J. Pediatr. Orthop."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.injury.2008.04.001","article-title":"Treatment of severely displaced proximal humeral fractures in children with retrograde elastic stable intramedullary nailing","volume":"39","author":"Fernandez","year":"2008","journal-title":"Injury"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/01.bpo.0000164872.44195.4f","article-title":"Complications of pediatric femur fractures treated with titanium elastic nails: A comparison of fracture types","volume":"25","author":"Sink","year":"2005","journal-title":"J. Pediatr. Orthop."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/01241398-200307000-00006","article-title":"Complications of titanium elastic nails for pediatric femoral shaft fractures","volume":"23","author":"Luhmann","year":"2003","journal-title":"J. Pediatr. Orthop."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"112519","DOI":"10.1016\/j.injury.2025.112519","article-title":"Diagnosis and treatment of fracture-related infection in children and adolescents: A retrospective study","volume":"56","author":"Kloub","year":"2025","journal-title":"Injury"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"378","DOI":"10.5152\/j.aott.2020.19128","article-title":"Elastic stable intramedullary nailing for treatment of pediatric forearm fractures: A 15-year single centre retrospective study of 173 cases","volume":"54","author":"Gulin","year":"2020","journal-title":"Acta Orthop. Traumatol. Turc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1302\/0301-620X.93B2.24882","article-title":"Elastic intramedullary nailing of paediatric fractures of the forearm: A decade of experience in a teaching hospital in the United Kingdom","volume":"93","author":"Kang","year":"2011","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s43465-024-01125-3","article-title":"Elastic Stable Intramedullary Nailing Versus Plate Internal Fixation for Pediatric Diaphyseal Femur Fractures: A Systematic Review and Meta-analysis","volume":"58","author":"Liu","year":"2024","journal-title":"Indian J. Orthop."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00402-021-03839-7","article-title":"Outcomes and complications following flexible intramedullary nailing for the treatment of tibial fractures in children: A meta-analysis","volume":"142","author":"Fanelli","year":"2022","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_36","first-page":"e43557","article-title":"Clinical and Radiological Outcomes of Paediatric Forearm Fractures of the Radius and Ulna Following Fixation by Intramedullary Nailing or Plating: A Systematic Review","volume":"15","author":"Mmerem","year":"2023","journal-title":"Cureus"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s00268-016-3753-1","article-title":"Plate Fixation Versus Intramedullary Nailing for Both-Bone Forearm Fractures: A Meta-analysis of Randomized Controlled Trials and Cohort Studies","volume":"41","author":"Zhao","year":"2017","journal-title":"World J. Surg."},{"key":"ref_38","first-page":"17","article-title":"Fracture-Related Infection-Epidemiology, Etiology, Diagnosis, Prevention, and Treatment","volume":"121","author":"Rupp","year":"2024","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s00264-017-3607-y","article-title":"Prevention of fracture-related infection: A multidisciplinary care package","volume":"41","author":"Metsemakers","year":"2017","journal-title":"Int. Orthop."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1097\/BPO.0b013e318270468b","article-title":"Immediate intramedullary flexible nailing of open pediatric tibial shaft fractures","volume":"32","author":"Pandya","year":"2012","journal-title":"J. Pediatr. Orthop."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1007\/s43465-023-00879-6","article-title":"Peri-operative Antibiotic Prophylaxis in K-Wire Fixation: A Systematic Review and Meta-analysis","volume":"57","author":"Abul","year":"2023","journal-title":"Indian J. Orthop."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/BPO.0b013e3181b768ac","article-title":"Complications after pinning of supracondylar distal humerus fractures","volume":"29","author":"Bashyal","year":"2009","journal-title":"J. Pediatr. Orthop."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/BPO.0b013e318269543b","article-title":"Evaluating the use of preoperative antibiotics in pediatric orthopaedic surgery","volume":"32","author":"Formaini","year":"2012","journal-title":"J. Pediatr. Orthop."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1186\/s13018-024-05158-0","article-title":"Intramedullary nail fixation versus open reduction and internal fixation for treatment of adult diaphyseal forearm fractures: A systematic review and meta-analysis","volume":"19","author":"Box","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2174\/1874325001307010219","article-title":"Management of infection after intramedullary nailing of long bone fractures: Treatment protocols and outcomes","volume":"7","author":"Makridis","year":"2013","journal-title":"Open Orthop. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.injury.2018.07.024","article-title":"Incidence and risk factors associated with infection after intramedullary nailing of femoral and tibial diaphyseal fractures: Prospective study","volume":"49","author":"Oliveira","year":"2018","journal-title":"Injury"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jss.2022.06.012","article-title":"Are Kids More Than Just Little Adults? A Comparison of Surgical Outcomes","volume":"279","author":"McMullin","year":"2022","journal-title":"J. Surg. Res."},{"key":"ref_48","first-page":"e022","article-title":"Surgical Wound Classification and Surgical Site Infections in the Orthopaedic Patient","volume":"1","author":"Onyekwelu","year":"2017","journal-title":"J. Am. Acad. Orthop. Surg. Glob. Res. Rev."}],"container-title":["Children"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/2\/168\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:55:06Z","timestamp":1769424906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2227-9067\/13\/2\/168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,25]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["children13020168"],"URL":"https:\/\/doi.org\/10.3390\/children13020168","relation":{},"ISSN":["2227-9067"],"issn-type":[{"value":"2227-9067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,25]]}}}