{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:09:17Z","timestamp":1769717357847,"version":"3.49.0"},"reference-count":99,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health with \u201cCurrent Research funds\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Children"],"abstract":"<jats:p>The search for an ideal anesthetic has always been a major goal in anesthesiology. In recent years, the introduction of ciprofol has marked a major breakthrough in the pharmacological field, following the introduction of dexmedetomidine. Ciprofol has similar characteristics to propofol but with greater hemodynamic stability. Furthermore, it overcomes one of the most common discomforts associated with propofol: pain at the injection site. These characteristics make it a suitable hypnotic for pediatric use. Although studies on children are still limited, the literature on adults is now substantial and of high quality. The potential advantages of using ciprofol in pediatric anesthesia include pain-free induction, hemodynamic stability, less respiratory depression, and a lower incidence of emergence delirium.<\/jats:p>","DOI":"10.3390\/children13020188","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:12:01Z","timestamp":1769677921000},"page":"188","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advantages of Ciprofol with Special Consideration of Pediatric Anesthesia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-3765","authenticated-orcid":false,"given":"Alessandro","family":"Vittori","sequence":"first","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, ARCO, Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, Piazza S. Onofrio 4, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Di Fabio","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences (MeSVA), University of L\u2019Aquila, Piazzale Salvatore Tommasi 1, Blocco 11, Coppito, 67010 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-3132","authenticated-orcid":false,"given":"Marco","family":"Cascella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, University of Salerno, Via Salvador Allende, 43, 84081 Baronissi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-7717","authenticated-orcid":false,"given":"Franco","family":"Marinangeli","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences (MeSVA), University of L\u2019Aquila, Piazzale Salvatore Tommasi 1, Blocco 11, Coppito, 67010 L\u2019Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-2391","authenticated-orcid":false,"given":"Elisa","family":"Francia","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, ARCO, Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, Piazza S. Onofrio 4, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6484-8436","authenticated-orcid":false,"given":"Ilaria","family":"Mascilini","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, ARCO, Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, Piazza S. Onofrio 4, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia Maria","family":"Pizzo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, ARCO, Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, Piazza S. Onofrio 4, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, ARCO, Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, Piazza S. Onofrio 4, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Di Conza","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples \u201cFederico II\u201d, Via Pansini, 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-912X","authenticated-orcid":false,"given":"Teresa","family":"Grimaldi Capitello","sequence":"additional","affiliation":[{"name":"Clinical Psychology Unit, Department of Neuroscience, Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, Piazza S. Onofrio 4, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-1371","authenticated-orcid":false,"given":"Giuliano","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Surgery Unit, Bios Medical Center, Via Domenico Chelini 39, 00197 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Servillo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples \u201cFederico II\u201d, Via Pansini, 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-6209","authenticated-orcid":false,"given":"Pasquale","family":"Buonanno","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples \u201cFederico II\u201d, Via Pansini, 5, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.bja.2018.12.025","article-title":"Propofol Infusion Syndrome: A Structured Literature Review and Analysis of Published Case Reports","volume":"122","author":"Hemphill","year":"2019","journal-title":"Br. 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